Gluten Degrading Enzymes for Treatment of Celiac Disease

Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo

(2019) Ghassan Darwish et al.   Scientific Reports

Outcome measures in coeliac disease trials: the Tampere recommendations

(2018) Jonas F Ludvigsson et al.   GUT

Nondietary Therapies for Celiac Disease

(2018) Gloria Serena et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Challenges in gluten-free diet in coeliac disease: Prague consensus

(2017) Gabriel Samasca et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

No Difference Between Latiglutenase and Placebo in Reducing Villous Atrophy or Improving Symptoms in Patients With Symptomatic Celiac Disease

(2017) Joseph A. Murray et al.   GASTROENTEROLOGY

Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice

(2017) Katharina Julia Werkstetter et al.   GASTROENTEROLOGY

Commercially available glutenases: a potential hazard in coeliac disease

(2017) Suneeta Krishnareddy et al.   Therapeutic Advances in Gastroenterology

Randomized clinical trial: Effective gluten degradation by Aspergillus niger-derived enzyme in a complex meal setting

(2017) Julia König et al.   Scientific Reports

Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease

(2016) Guoxian Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Coeliac disease and the gluten-free diet: a review of the burdens; factors associated with adherence and impact on health-related quality of life, with specific focus on adolescence

(2016) L. E. White et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

In vivo protein quality of selected cereal-based staple foods enriched with soybean proteins

(2016) Laura Acevedo-Pacheco et al.   Food & Nutrition Research

Randomised clinical study:Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers

(2015) B. N. Salden et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Identification of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High Therapeutic Potential for Celiac Disease

(2015) Guoxian Wei et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions

(2015) Clancey Wolf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Celiac disease and non-celiac gluten sensitivity

(2015) Benjamin Lebwohl et al.   BMJ-British Medical Journal

Celiac disease and non-celiac gluten sensitivity

(2015) Benjamin Lebwohl et al.   BMJ-British Medical Journal

Effect of Rothia mucilaginosa enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes relevant to celiac disease

(2014) Na Tian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Advances in coeliac disease

(2014) Knut E.A. Lundin et al.   CURRENT OPINION IN GASTROENTEROLOGY

Glutenase ALV003 Attenuates Gluten-Induced Mucosal Injury in Patients With Celiac Disease

(2014) Marja-Leena Lähdeaho et al.   GASTROENTEROLOGY

The cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity

(2013) M. Fernandez-Feo et al.   CLINICAL MICROBIOLOGY AND INFECTION

Biochemical and Functional Properties of Wheat Gliadins: A Review

(2013) Sheweta Barak et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study

(2013) Greetje J Tack   WORLD JOURNAL OF GASTROENTEROLOGY

Computational Design of an α-Gliadin Peptidase

(2012) Sydney R. Gordon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel therapies for coeliac disease

(2011) L. M. Sollid et al.   JOURNAL OF INTERNAL MEDICINE

Identification of Rothia Bacteria as Gluten-Degrading Natural Colonizers of the Upper Gastro-Intestinal Tract

(2011) Maram Zamakhchari et al.   PLoS One

In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract

(2011) G. Fuhrmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Update on Serologic Testing in Celiac Disease

(2010) Daniel A Leffler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Effects of Crop Nutrition on Wheat Grain Composition and End Use Quality

(2010) Dan Godfrey et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Human Oral Microbiome

(2010) F. E. Dewhirst et al.   JOURNAL OF BACTERIOLOGY

Discovery of a Novel and Rich Source of Gluten-Degrading Microbial Enzymes in the Oral Cavity

(2010) Eva J. Helmerhorst et al.   PLoS One

The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo

(2009) Jason A. Tye-Din et al.   CLINICAL IMMUNOLOGY

Celiac Disease: From Pathogenesis to Novel Therapies

(2009) Detlef Schuppan et al.   GASTROENTEROLOGY

A Food-Grade Enzyme Preparation with Modest Gluten Detoxification Properties

(2009) Jennifer Ehren et al.   PLoS One

Identification of Lys-Pro-Gln as a Novel Cleavage Site Specificity of Saliva-associated Proteases

(2008) Eva J. Helmerhorst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transepithelial Transport and Enzymatic Detoxification of Gluten in Gluten-Sensitive Rhesus Macaques

(2008) Michael T. Bethune et al.   PLoS One