Protease inhibition as new therapeutic strategy for GI diseases

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

(2015) Nicolas Cenac et al.   GASTROENTEROLOGY

The functional and pathologic relevance of autophagy proteases

(2015) Álvaro F. Fernández et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Role of the Serine Protease Inhibitor Elafin in Gluten-Related Disorders

(2014) Heather J Galipeau et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Giardia duodenalis Cathepsin B Proteases Degrade Intestinal Epithelial Interleukin-8 and Attenuate Interleukin-8-Induced Neutrophil Chemotaxis

(2014) James A. Cotton et al.   INFECTION AND IMMUNITY

Neutrophil Gelatinase B–associated Lipocalin and Matrix Metalloproteinase-9 Complex as a Surrogate Serum Marker of Mucosal Healing in Ulcerative Colitis

(2014) Magali de Bruyn et al.   INFLAMMATORY BOWEL DISEASES

Cathepsin S Causes Inflammatory PainviaBiased Agonism of PAR2and TRPV4

(2014) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil-mediated Activation of Epithelial Protease-Activated Receptors-1 and -2 Regulates Barrier Function and Transepithelial Migration

(2014) A. C. Chin et al.   JOURNAL OF IMMUNOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome

(2014) Y. Nasser et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Giardia duodenalis Infection Reduces Granulocyte Infiltration in an In Vivo Model of Bacterial Toxin-Induced Colitis and Attenuates Inflammation in Human Intestinal Tissue

(2014) James A. Cotton et al.   PLoS One

Microbial-induced meprin   cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

(2014) A. Schutte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitization of Peripheral Sensory Nerves by Mediators From Colonic Biopsies of Diarrhea-Predominant Irritable Bowel Syndrome Patients: A Role for PAR2

(2013) Eduardo E Valdez-Morales et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Engineering lactococci and lactobacilli for human health

(2013) Luis G. Bermúdez-Humarán et al.   CURRENT OPINION IN MICROBIOLOGY

Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit

(2013) David Tooth et al.   GUT

Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease

(2013) Isabelle Cleynen et al.   GUT

High Expression of the “A Disintegrin And Metalloprotease” 19 (ADAM19), a Sheddase for TNF-α in the Mucosa of Patients with Inflammatory Bowel Diseases

(2013) Eleonora Franzè et al.   INFLAMMATORY BOWEL DISEASES

Site-specificO-Glycosylation on the MUC2 Mucin Protein Inhibits Cleavage by thePorphyromonas gingivalisSecreted Cysteine Protease (RgpB)

(2013) Sjoerd van der Post et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

Fecal Protease Activity Is Associated with Compositional Alterations in the Intestinal Microbiota

(2013) Ian M. Carroll et al.   PLoS One

Missing the target: matrix metalloproteinase antitargets in inflammation and cancer

(2013) Antoine Dufour et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications

(2013) Ian M Carroll   WORLD JOURNAL OF GASTROENTEROLOGY

SLPI and elafin: multifunctional antiproteases of the WFDC family

(2012) Aaron Scott et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon

(2012) Maria Arampatzidou et al.   BIOLOGICAL CHEMISTRY

Proteases and the gut barrier

(2012) Paolo Biancheri et al.   CELL AND TISSUE RESEARCH

Lactocepin Secreted By Lactobacillus Exerts Anti-Inflammatory Effects By Selectively Degrading Proinflammatory Chemokines

(2012) Marie-Anne von Schillde et al.   Cell Host & Microbe

The Impact of Matrix Metalloproteinases and Their Tissue Inhibitors in Inflammatory Bowel Diseases

(2012) Gábor Lakatos et al.   DIGESTIVE DISEASES

Tissue Inhibitor of Metalloproteinase-3 Regulates Inflammation in Human and Mouse Intestine

(2012) Ivan Monteleone et al.   GASTROENTEROLOGY

Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα

(2012) Caroline Swan et al.   GUT

Cleavage of IgG1 in gingival crevicular fluid is associated with the presence ofPorphyromonas gingivalis

(2012) A. Guentsch et al.   JOURNAL OF PERIODONTAL RESEARCH

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

(2012) J.-P. Motta et al.   Science Translational Medicine

Serine Protease(s) Secreted by the Nematode Trichuris muris Degrade the Mucus Barrier

(2012) Sumaira Z. Hasnain et al.   PLoS Neglected Tropical Diseases

Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis

(2011) Jean–Paul Motta et al.   GASTROENTEROLOGY

Activity of Protease-Activated Receptors in the Human Submucous Plexus

(2011) Kerstin Mueller et al.   GASTROENTEROLOGY

Matriptase Protects Against Experimental Colitis and Promotes Intestinal Barrier Recovery

(2011) Sarah Netzel-Arnett et al.   INFLAMMATORY BOWEL DISEASES

Inflammatory Skin and Bowel Disease Linked toADAM17Deletion

(2011) Diana C. Blaydon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Evidence Supporting the Association of Protease and Protease Inhibitor Genes with Inflammatory Bowel Disease: A Systematic Review

(2011) Isabelle Cleynen et al.   PLoS One

Subjects with Diarrhea-Predominant IBS Have Increased Rectal Permeability Responsive to Tryptase

(2010) Jae Woong Lee et al.   DIGESTIVE DISEASES AND SCIENCES

TNF  is a key mediator of the pronociceptive effects of mucosal supernatant from human ulcerative colitis on colonic DRG neurons

(2010) C. Ibeakanma et al.   GUT

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

(2010) Chrystelle Bonnart et al.   JOURNAL OF CLINICAL INVESTIGATION

The paradox of the neutrophilˈs role in tissue injury

(2010) George B. Segel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon mucus

(2010) D. Subramani et al.   Beneficial Microbes

Increased Proteasome-Mediated Degradation of Occludin in Irritable Bowel Syndrome

(2009) Moïse Coëffier et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase Cζ

(2009) Veronica A. Swystun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Differential expression and regulation of ADAM17 and TIMP3 in acute inflamed intestinal epithelia

(2009) Annabelle Cesaro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome

(2009) Sabine Buhner et al.   GASTROENTEROLOGY

Protease-activated receptor-4 (PAR4): a role as inhibitor of visceral pain and hypersensitivity

(2009) c. augé et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice

(2009) Anita Annaházi et al.   PAIN

Protease-activated receptors as drug targets in inflammation and pain

(2009) Nathalie Vergnolle   PHARMACOLOGY & THERAPEUTICS

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

(2009) R. J. Brezski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Receptor Potential Vanilloid-4 Has a Major Role in Visceral Hypersensitivity Symptoms

(2008) Nicolas Cenac et al.   GASTROENTEROLOGY

Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways

(2008) Stuart M. Brierley et al.   GASTROENTEROLOGY

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

(2008) T Piche et al.   GUT

Proteinase-activated receptors (PARs) in infection and inflammation in the gut

(2008) N VERGNOLLE   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients

(2008) a. p. m. kerckhoffs et al.   NEUROGASTROENTEROLOGY AND MOTILITY