Recent advances towards mass spectrometry-based clinical lipidomics

A simple and rapid method for extraction and measurement of circulating sphingolipids using LC–MS/MS: a targeted lipidomic analysis

(2022) Yifan Xu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis

(2022) Guangxi Wang et al.   Science Translational Medicine

Lipidomic profiling of human serum enables detection of pancreatic cancer

(2022) Denise Wolrab et al.   Nature Communications

Serum metabolome associated with severity of acute traumatic brain injury

(2022) Ilias Thomas et al.   Nature Communications

Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort

(2022) Chris Lauber et al.   PLOS BIOLOGY

Advanced unified monophasic lipid extraction protocol with wide coverage on the polarity scale optimized for large-scale untargeted clinical lipidomics analysis of platelets

(2022) Xiaoqing Fu et al.   ANALYTICA CHIMICA ACTA

Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study

(2022) Sartaj Ahmad Mir et al.   BMC Medicine

Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies

(2022) Gavriel Olshansky et al.   PROGRESS IN LIPID RESEARCH

Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease

(2022) Gemma Cadby et al.   Nature Communications

Comprehensive lipidomic profiling by plasma separation cards

(2022) Lauren M. Bishop et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Benchmarking One-Phase Lipid Extractions for Plasma Lipidomics

(2022) Marcus Höring et al.   ANALYTICAL CHEMISTRY

Evaluation of volumetric blood collection devices for the measurement of phenylalanine and tyrosine to monitor patients with phenylketonuria

(2022) Rachel S. Carling et al.   CLINICA CHIMICA ACTA

High Throughput LC-MS Platform for Large Scale Screening of Bioactive Polar Lipids in Human Plasma and Serum

(2022) Nyasha Munjoma et al.   JOURNAL OF PROTEOME RESEARCH

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease

(2022) Priyanka Baloni et al.   Communications Biology

Volumetric Absorptive Microsampling of Blood for Untargeted Lipidomics

(2021) Camilla Marasca et al.   MOLECULES

A plasma lipid signature predicts incident coronary artery disease

(2021) Filip Ottosson et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Studying Autism Using Untargeted Metabolomics in Newborn Screening Samples

(2021) Julie Courraud et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19

(2021) Marianna Caterino et al.   Scientific Reports

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis

(2021) Geraldine J. Ooi et al.   JOURNAL OF HEPATOLOGY

Plasma Phospholipidomic Profile Differs between Children with Phenylketonuria and Healthy Children

(2021) Inês M. S. Guerra et al.   JOURNAL OF PROTEOME RESEARCH

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption

(2021) Bethan L. Clifford et al.   Cell Metabolism

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

(2021) Joan Clària et al.   JOURNAL OF HEPATOLOGY

Nontargeted mass spectrometry of dried blood spots for interrogation of the human circulating metabolome

(2021) Casey Ward et al.   JOURNAL OF MASS SPECTROMETRY

Bridging the Polar and Hydrophobic Metabolome in Single-Run Untargeted Liquid Chromatography-Mass Spectrometry Dried Blood Spot Metabolomics for Clinical Purposes

(2021) Hanne Bendiksen Skogvold et al.   JOURNAL OF PROTEOME RESEARCH

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

(2021) Mojgan Masoodi et al.   Nature Reviews Gastroenterology & Hepatology

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

(2021) Zhiqiang Pang et al.   NUCLEIC ACIDS RESEARCH

Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris

(2021) Shuai Shao et al.   JCI Insight

Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring

(2021) Mohan Ghorasaini et al.   ANALYTICAL CHEMISTRY

LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin therapy on bioactive lipids and dense LDL

(2020) M. John Chapman et al.   JOURNAL OF LIPID RESEARCH

Combining lipidomics and machine learning to measure clinical lipids in dried blood spots

(2020) Stuart G. Snowden et al.   Metabolomics

Evaluating a targeted multiple reaction monitoring approach to global untargeted lipidomic analyses of human plasma

(2020) Mostafa J. Khan et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Nontargeted lipidomics of novel human plasma reference materials: hypertriglyceridemic, diabetic, and African-American

(2020) Juan J. Aristizabal-Henao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Feature-based molecular networking in the GNPS analysis environment

(2020) Louis-Félix Nothias et al.   NATURE METHODS

Concussion Acutely Decreases Plasma Glycerophospholipids in Adolescent Male Athletes

(2020) Michael R. Miller et al.   JOURNAL OF NEUROTRAUMA

Characterization of Monophasic Solvent-Based Tissue Extractions for the Detection of Polar Metabolites and Lipids Applying Ultrahigh-Performance Liquid Chromatography–Mass Spectrometry Clinical Metabolic Phenotyping Assays

(2020) Andrew D. Southam et al.   JOURNAL OF PROTEOME RESEARCH

Single-Step Extraction Coupled with Targeted HILIC-MS/MS Approach for Comprehensive Analysis of Human Plasma Lipidome and Polar Metabolome

(2020) Jessica Medina et al.   Metabolites

Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients

(2019) Mika Hilvo et al.   EUROPEAN HEART JOURNAL

Shared reference materials harmonize lipidomics across MS-based detection platforms and laboratories

(2019) Alexander Triebl et al.   JOURNAL OF LIPID RESEARCH