Article
Endocrinology & Metabolism
Anika K. Anam, Katherine M. Cooke, Milana Bochkur Dratver, Jane O'Bryan, Lauren E. Perley, Seth M. Guller, Janice J. Hwang, Hugh S. Taylor, Leigh Goedeke, Harvey J. Kliman, Daniel F. Vatner, Clare A. Flannery
Summary: Maternal obesity increases the risk of excess adiposity in newborns, which may be attributed to alterations in maternal metabolism such as hyperinsulinemia under euglycemic conditions, affecting placental metabolism and leading to increased fetal adiposity.
MOLECULAR METABOLISM
(2022)
Article
Chemistry, Analytical
Leicheng Zhang, Tengfei Xu, Jingtao Zhang, Stephen Choong Chee Wong, Mark Ritchie, Han Wei Hou, Yulan Wang
Summary: The study proposes a novel strategy integrating spiral inertial microfluidics and ion mobility mass spectrometry for single-cell metabolite detection and identification. The technology successfully screened the metabolic profiles of different types of cancer cells, improving confidence in metabolite identification. This approach offers a simple and efficient method for single-cell lipid profiling, with additional ion mobility separation significantly enhancing the confidence toward identification of metabolites.
ANALYTICAL CHEMISTRY
(2021)
Article
Horticulture
Yu Ge, Xiaoping Zang, Yuanzheng Liu, Lixia Wang, Jiashui Wang, Yanxia Li, Weihong Ma
Summary: The study compared lipid droplets, fatty acid compositions, and gene expression profiles of mature avocado mesocarps from three ecotypes, revealing differences in mesocarp oil contents. Lipidomics and metabolomics analyses showed significant variations in lipid and other metabolites among the examined avocado ecotypes, identifying potential candidate biomarkers for distinguishing diverse avocado ecotypes. This is the first comprehensive metabolomics-based comparative investigation of lipid and other metabolites among three avocado ecotypes.
Article
Food Science & Technology
Emma Sherman, Farhana R. Pinu
Summary: The scientific interest in lipids and lipidomics approaches is growing due to the development of mass spectrometry-based instrumentation and data analysis pipelines. While widely used in biomedical studies, lipidomics applications in food and plant systems, such as grape and wine research, are still developing. The adoption of lipidomics in studying grape and wine research can bring innovative advances to the wine industry worldwide.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra Hliwa, Bruno Ramos-Molina, Dariusz Laski, Adriana Mika, Tomasz Sledzinski
Summary: Non-alcoholic fatty liver disease (NAFLD) is a major global public health problem characterized by alterations in hepatic lipid metabolism that can lead to serious liver complications. Mass spectrometry-based lipidomics platforms allow for in-depth analysis of lipid changes in NAFLD patients, focusing on alterations in long-chain and short-chain fatty acids levels as well as the expression of genes encoding lipid interconversion enzymes in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Chunying Huang, Yan Li, Ketao Wang, Jianwei Xi, Yifan Xu, Xiaolin Si, Dong Pei, Shiheng Lyu, Guohua Xia, Jianhua Wang, Peipei Li, Hongyu Ye, Yulin Xing, Yige Wang, Jianqin Huang
Summary: Hickory nuts are rich in lipids with high nutritional value and health benefits, with a lipid composition mainly consisting of glycerolipids and glycerophospholipids. The dynamic changes in lipids during embryonic development, particularly the role of diacylglycerols, play a significant role in accumulation of glycerolipids and glycerophospholipids, containing unsaturated fatty acids such as oleic acid, linoleic acid and linolenic acid mainly at sn-2 lipid position.
Article
Environmental Sciences
Hongli Liu, Yixiu Bai, Yingying Yu, Zenghua Qi, Guoxia Zhang, Guiying Li, Yingxin Yu, Taicheng An
Summary: By orally exposing female Sprague Dawley rats to Resorcinol-bis(diphenyl)-phosphate (RDP) during pregnancy and lactation, it was found that RDP accumulated in the livers of maternal rats and offspring, and its level increased with exposure time. The exposure to RDP also disrupted the gut microbiota homeostasis and altered gut microbiome-related metabolism. These findings suggest that RDP has significant adverse effects on gut microbiota and metabolic function, which may increase the long-term risks of inflammation, obesity, and metabolic diseases.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Qiting Qing, Lili Huang, Wanxiao Sun, Jing Chen, Ningning Yu, Yuanhua Chen, Dexiang Xu, Mei Zhao
Summary: This study investigated the effects of maternal lipopolysaccharide (LPS) exposure during pregnancy on metabolic profiling of maternal serum and male fetal liver. The results revealed alterations in glycerophospholipid and fatty acid metabolites in both maternal serum and male fetal livers, with an upregulation of glycerophospholipids containing saturated fatty acids (SFAs) and downregulation of those containing polyunsaturated fatty acids (PUFAs). This concordance between maternal and fetal alterations in metabolites may provide insight into the mechanisms by which maternal LPS exposure induces metabolic disorders in male offspring.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Review
Physiology
Matteo Vietri Rudan, Fiona M. Watt
Summary: Mammalian epidermal lipids play a significant role in tissue biology by forming an impermeable barrier, protecting against external insults, shaping the commensal microbiota, and modulating immune responses and epidermal differentiation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Greta Dancu, Cristi Tarta, Carmen Socaciu, Felix Bende, Mirela Danila, Roxana Sirli, Ioan Sporea, Bogdan Miutescu, Alina Popescu
Summary: This study utilized serum metabolomics to identify potential diagnostic markers for acute pancreatitis (AP) and distinguish between its different etiologies. The research provides insights into the metabolic landscape of AP and highlights the potential for new diagnostic biomarkers and therapeutic strategies.
Article
Chemistry, Medicinal
Tiago A. Conde, Bruna F. Neves, Daniela Couto, Tania Melo, Bruno Neves, Margarida Costa, Joana Silva, Pedro Domingues, M. Rosario Domingues
Summary: The study used gas-chromatography mass-spectrometry to characterize the fatty acid profiles of seven different commercial microalgae, revealing unique compositions among them, especially in terms of omega-3 fatty acids, with species of the same phylum showing similar trends. Additionally, the research found that different lipid extracts exhibited comparable antioxidant activities, further demonstrating the potential of microalgae as sustainable and healthy sources of essential lipids.
Article
Developmental Biology
Zhongmei Yang, Xiaofang Luo, Biao Huang, Xiaoyan Jia, Xiaojin Luan, Nan Shan, Zhongling An, Jinfeng Cao, Hongbo Qi
Summary: Fetal growth restriction (FGR) is a common complication of pregnancy, and lipid metabolism may play a role in its development. However, the metabolic mechanisms of FGR are not well understood. This study used metabolomic profiling and gene analysis to identify metabolic profiles and potential genes and signaling pathways associated with FGR. The results showed that fatty acids accumulated in the placenta and decreased in fetal blood in FGR cases compared to controls, and linoleic acid metabolism was the focus of differential metabolite and gene enrichment analysis in the placenta.
Article
Biochemistry & Molecular Biology
Felisa Rey, Paulo Cartaxana, Susana Aveiro, Michael Greenacre, Tania Melo, Pedro Domingues, M. Rosario Domingues, Sonia Cruz
Summary: A study on the sea slug Elysia timida revealed that light intensity influences the degradation of stolen chloroplasts (kleptoplasts), with older kleptoplasts being targeted for degradation. The lipidome of E. timida showed differences under different light treatments, indicating a light-driven remodelling of the lipidome.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Review
Biochemistry & Molecular Biology
Santosh Lamichhane, Partho Sen, Marina Amaral Alves, Henrique C. Ribeiro, Peppi Raunioniemi, Tuulia Hyotylainen, Matej Oresic
Summary: Recent studies have shown that microbial lipids can alter lipid concentrations in the host, affecting human lipid homeostasis. The gut microbial communities play a significant role in regulating host cholesterol and sphingolipid homeostasis, highlighting their importance in health and disease.
Article
Chemistry, Applied
Zou Ligen, Wang Qian, Weng Liping, Wang Tenghao, Qiu Jing, Liu Junbo, Jiang Huiyan, Wu Yuanfeng
Summary: Lipids play a crucial role in the salting process of duck eggs. The low-salt pickling process maintains the quality of salted duck egg yolks and is considered a healthier alternative to traditional curing methods. The levels of saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids increase during salting. Lipidomics analysis reveals significant differences in 39 lipids in the phospholipid family, with lysophosphatidylcholine, lysophosphatidylethanolamine, and phosphatidylcholine identified as differential lipids that increase in abundance after low-salt pickling.
Article
Nutrition & Dietetics
Yi Ying Ong, Wei Wei Pang, Navin Michael, Izzuddin M. Aris, Suresh Anand Sadananthan, Mya-Thway Tint, Jonathan Tze Liang Choo, Lieng Hsi Ling, Neerja Karnani, S. Sendhil Velan, Marielle V. Fortier, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith M. Godfrey, Shiao-Yng Chan, Johan G. Eriksson, Mary F-F Chong, Mary E. Wlodek, Yung Seng Lee
Summary: This study examined the effects of the timing of introduction of complementary foods and the duration of breastfeeding on body fat partitioning and cardiometabolic risk in children. The results showed that shorter breastfeeding duration and earlier introduction of complementary foods were associated with increased child adiposity and cardiometabolic risk. Longer duration of breastfeeding may protect against the cardiometabolic risk associated with early introduction of complementary foods.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Correction
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schueller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
ACTA NEUROPATHOLOGICA
(2023)
Article
Biotechnology & Applied Microbiology
Xi Yuan, Jiayu Huang, Li Wen, Boris Novakovic, Mark D. Kilby, Chao Tong, Hongbo Qi, Richard Saffery, Philip N. Baker
Summary: Despite being genetically identical, monozygotic (MZ) twins can have discordant congenital heart disease (CHD) due to in utero environmental factors. This study identified epigenetic variations in cord blood of discordant MZ twins that are associated with CHD. The results revealed specific DNA methylation variations that are biomarkers and potential targets for intervention in CHD.
Article
Cell Biology
Samira Imran, Melanie R. Neeland, David J. J. Martino, Stephen Peng, Jennifer Koplin, Shyamali C. Dharmage, Mimi L. K. Tang, Susan Sawyer, Thanh Dang, Vicki McWilliam, Rachel L. Peters, Susan Prescott, Kirsten P. Perrett, Boris Novakovic, Richard Saffery
Summary: Childhood is a critical period of immune development, and the epigenetic signatures associated with CD4 T cell activation during different developmental stages are yet to be described. A study investigated the DNA methylation changes associated with nCD4 T activation in infants and adolescents, and found similar extensive epigenetic reprogramming in both age groups. However, age-specific effects were identified in terms of methylation and cytokine responses, which may contribute to variation in disease risk and immune function.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Pediatrics
Delicia Shu Qin Ooi, Siong Gim Ong, Jace Ming Xuan Chia, Yvonne Yijuan Lim, Cindy Wei Li Ho, Veronica Tay, K. Vijaya, Kah Yin Loke, Andrew Anjian Sng, Konstadina Griva, Yung Seng Lee
Summary: This study compared health-related quality of life (HRQoL) and psychosocial outcomes between children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) using validated questionnaires. The results showed that children with MUO and prior knowledge of existing metabolic conditions had lower HRQoL, higher depression, and stress than children with MHO. Additionally, the metabolic health status of fathers was found to influence HRQoL in children with MUO.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Jun S. Lai, Marjorelee T. Colega, Keith M. Godfrey, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Yung Seng Lee, Johan G. Eriksson, Shiao-Yng Chan, Mary F. F. Chong
Summary: Adopting a healthy diet during and after pregnancy is important for women's cardiometabolic health. Changes in diet quality from pregnancy to 6 years postpregnancy were related to cardiometabolic markers 8 years postpregnancy in a study of 652 women. Improving or preventing a decline in diet quality postpregnancy may improve lipid profile and insulin resistance.
Review
Biology
Aaron W. Jurrjens, Marcus M. Seldin, Corey Giles, Peter J. Meikle, Brian G. Drew, Anna C. Calkin
Summary: Cardiometabolic diseases result from genetic, environmental, and lifestyle factors and identifying those at high risk is challenging. Systems genetics, using population-based approaches, can elucidate the genetic and environmental causes of these diseases. Mouse genetic reference panels provide a complementary approach to human genome-wide association studies, allowing for controlled investigation of genetic and phenotypic variation. Integrating multi-omics data from human and mouse populations can advance our understanding of cardiometabolic diseases.
Article
Physiology
Hannah E. J. Yong, Oliver C. Watkins, Tania K. L. Mah, Victoria K. B. Cracknell-Hazra, Reshma Appukuttan Pillai, Preben Selvam, Mohammad O. Islam, Neha Sharma, Amaury Cazenave-Gassiot, Anne K. Bendt, Markus R. Wenk, Keith M. Godfrey, Rohan M. Lewis, Shiao-Yng Chan
Summary: Older pregnant women have increased risks of complications including gestational diabetes and stillbirth. This study investigates the decline in the expression of the enzyme CPT1B in the placenta with age and its association with placental acylcarnitine synthesis. The findings suggest that the age-related decline in CPT1B may contribute to pregnancy complications in older women, particularly if they are overweight.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dantong Zhu, Stephen T. Vernon, Zac D'Agostino, Jingqin Wu, Corey Giles, Adam S. Chan, Katharine A. Kott, Michael P. Gray, Alireza Gholipour, Owen Tang, Habtamu B. Beyene, Ellis Patrick, Stuart M. Grieve, Peter J. Meikle, Gemma A. Figtree, Jean Y. H. Yang
Summary: The current CAD risk scores based on traditional risk factors often fail individuals. We aim to identify lipidomic biomarkers using non-invasive imaging technology and advanced lipidomic measurement to enable intervention before cardiovascular events.
Article
Endocrinology & Metabolism
Siong Gim Ong, Roghayeh Dehghan, Rajkumar Dorajoo, Jian-Jun Liu, Andrew Anjian Sng, Yung Seng Lee, Delicia Shu Qin Ooi
Summary: The study aims to identify and functionally characterize MC3R and MC4R variants in an Asian cohort of children with severe early-onset obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Neurosciences
Elisa Weiss, Anna Schruefer, Carolina Tocantins, Mariana Simoes Diniz, Boris Novakovic, Anke S. van Bergen, Azra Kulovic-Sissawo, Richard Saffery, Reinier. A. A. Boon, Ursula Hiden
Summary: High gestational weight gain (GWG) is associated with impaired wound healing of neonatal endothelial colony forming cells (ECFCs). A specific long non-coding RNA (lncRNA), KLRK1-AS1, was found to be downregulated in neonatal ECFCs from pregnancies with higher GWG, and its knockdown resulted in further impairment of barrier recovery. These findings suggest a potential role for lncRNAs, particularly KLRK1-AS1, in regulating neonatal ECFC function and may provide insights into the link between GWG and cardiovascular risk factors.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Multidisciplinary Sciences
Ebru Boslem, Saskia Reibe, Rodrigo Carlessi, Benoit Smeuninx, Surafel Tegegne, Casey L. Egan, Emma Mclennan, Lauren V. Terry, Max Nobis, Andre Mu, Cameron Nowell, Neil Horadagoda, Natalie A. Mellett, Paul Timpson, Matthew Jones, Elena Denisenko, Alistair R. R. Forrest, Janina E. E. Tirnitz-Parker, Peter J. Meikle, Stefan Rose-John, Michael Karin, Mark A. Febbraio
Summary: The incidence of hepatocellular carcinoma (HCC) is increasing due to obesity-related nonalcoholic steatohepatitis (NASH). In a mouse model mimicking NASH-driven HCC, activation of endoplasmic reticulum stress and inflammation was observed in hepatocytes. Treatment with an ER stress inhibitor and an anti-inflammatory drug reversed NASH and reduced NASH-driven HCC.
Article
Medicine, General & Internal
Taeho Jo, Junpyo Kim, Paula Bice, Kevin Huynh, Tingting Wang, Matthias Arnold, Peter J. Meikle, Corey Giles, Rima Kaddurah-Daouk, Andrew J. Saykin, Kwangsik Nho
Summary: This study introduces the Circular-Sliding Window Association Test (c-SWAT) to improve the classification accuracy in predicting Alzheimer's Disease (AD) using serum-based metabolomics data. The results show that c-SWAT is effective in improving classification accuracy and in identifying key lipids associated with AD.
Article
Public, Environmental & Occupational Health
Anne H. Y. Chu, Natarajan Padmapriya, Shuen Lin Tan, Claire Marie J. L. Goh, Yap-Seng Chong, Lynette P. Shek, Kok Hian Tan, Peter D. Gluckman, Fabian K. P. Yap, Yung Seng Lee, See Ling Loy, Jerry K. Y. Chan, Keith M. Godfrey, Johan G. Eriksson, Shiao-Yng Chan, Jonathan Y. Bernard, Falk Muller-Riemenschneider
Summary: This study examined longitudinal changes in physical activity and sedentary behavior patterns from preconception to postpartum. The findings showed that walking time increased during late pregnancy, while vigorous-intensity physical activity and moderate to vigorous physical activity decreased but partially returned to preconception levels postpartum. Sedentary time remained stable during pregnancy but decreased postpartum. Individual characteristics such as ethnicity, body mass index, employment, parity, and self-rated general health significantly influenced women's activity patterns.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)