Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence

Readout of histone methylation by Trim24 locally restricts chromatin opening by p53

(2023) Luke Isbel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

(2022) Cyril Statzer et al.   Nature Communications

Sentinel p16 INK4a+ cells in the basement membrane form a reparative niche in the lung

(2022) Nabora S. Reyes et al.   SCIENCE

Oxidative post translational modifications: a focus on cysteine S-sulfhydration and the regulation of endothelial fitness

(2021) Sofia-Iris Bibli et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen sulfide in ageing, longevity and disease

(2021) Stephen E. Wilkie et al.   BIOCHEMICAL JOURNAL

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

Mapping the Endothelial Cell S -Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function

(2020) Sofia-Iris Bibli et al.   CIRCULATION

Telomere attrition: metabolic regulation and signalling function?

(2019) Stefania Casagrande et al.   Biology Letters

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

(2019) Jasmina Zivanovic et al.   Cell Metabolism

Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation

(2019) Sofia-Iris Bibli et al.   Redox Biology

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein HuR to Preserve Endothelial Cell Function and Delay Atherogenesis

(2018) Sofia-Iris Bibli et al.   CIRCULATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities

(2018) Austin I. McDonald et al.   Cell Stem Cell

Mechanisms of Vascular Aging

(2018) Zoltan Ungvari et al.   CIRCULATION RESEARCH

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53

(2016) Taniya Saha et al.   Scientific Reports

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway

(2015) Christopher Hine et al.   EXPERIMENTAL GERONTOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells

(2015) A L Fitzgerald et al.   Cell Death & Disease

Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway

(2014) Christina M. Warboys et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

p63 and p73 coordinate p53 function to determine the balance between survival, cell death and senescence in adult neural precursor cells

(2014) M P Fatt et al.   CELL DEATH AND DIFFERENTIATION

p53 induces skin aging by depleting Blimp1+ sebaceous gland cells

(2014) J Kim et al.   Cell Death & Disease

p53 Acetylation: Regulation and Consequences

(2014) Sara Reed et al.   Cancers

Preferential binding of p53 tumor suppressor to p21 promoter sites that contain inverted repeats capable of forming cruciform structure

(2013) Jan Coufal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

(2013) S. Rokudai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

The Rate of Increase of Short Telomeres Predicts Longevity in Mammals

(2012) Elsa Vera et al.   Cell Reports

The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans

(2010) Alexandre Marchand et al.   AGING CELL

p53 stabilization: the importance of nuclear import

(2010) J-C Marine   CELL DEATH AND DIFFERENTIATION

Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding

(2009) N D Marchenko et al.   CELL DEATH AND DIFFERENTIATION

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL