The proper timing of Atoh1 expression is pivotal for hair cell subtype differentiation and the establishment of inner ear function

Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish

(2021) Masahito Ogawa et al.   SCIENCE

Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea

(2021) Yan Chen et al.   Cell Reports

Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics

(2021) Taha A. Jan et al.   Cell Reports

Sustained Loss of Bdnf Affects Peripheral but Not Central Vestibular Targets

(2021) Karen L. Elliott et al.   Frontiers in Neurology

Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations

(2020) Kazuya Ono et al.   Nature Communications

Using Sox2 to alleviate the hallmarks of age-related hearing loss

(2020) Ebenezer N. Yamoah et al.   AGEING RESEARCH REVIEWS

Development of hair cell phenotype and calyx nerve terminals in the neonatal mouse utricle

(2019) Mark E. Warchol et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Multiple supporting cell subtypes are capable of spontaneous hair cell regeneration in the neonatal mouse cochlea

(2019) Melissa M. McGovern et al.   DEVELOPMENT

Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System

(2019) Zahra N. Sayyid et al.   Cell Reports

Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2

(2019) Martina Dvorakova et al.   DEVELOPMENTAL BIOLOGY

Renewed proliferation in adult mouse cochlea and regeneration of hair cells

(2019) Yilai Shu et al.   Nature Communications

Characterizing a novel vGlut3-P2A-iCreER knockin mouse strain in cochlea

(2018) Chao Li et al.   HEARING RESEARCH

Understanding Molecular Evolution and Development of the Organ of Corti Can Provide Clues for Hearing Restoration

(2018) Israt Jahan et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Oncomodulin Expression Reveals New Insights into the Cellular Organization of the Murine Utricle Striola

(2018) Larry F. Hoffman et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration

(2018) Ruben Eggers et al.   BRAIN

Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers

(2018) Stephen McInturff et al.   Biology Open

Surgery-free video-oculography in mouse models: enabling quantitative and short-interval longitudinal assessment of vestibular function

(2018) Xiaojie Yang et al.   NEUROSCIENCE LETTERS

Development and regeneration of vestibular hair cells in mammals

(2017) Joseph C. Burns et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

In Vivo Interplay between p27 Kip1 , GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice

(2017) Bradley J. Walters et al.   Cell Reports

Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

(2017) Stephanie A Bucks et al.   eLife

Epigenetic regulation ofAtoh1guides hair cell development in the mammalian cochlea

(2016) Zlatka P. Stojanova et al.   DEVELOPMENT

Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea

(2016) Wenli Ni et al.   JOURNAL OF NEUROSCIENCE

Auditory neuropathy — neural and synaptic mechanisms

(2016) Tobias Moser et al.   Nature Reviews Neurology

Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development

(2015) I. Jahan et al.   DEVELOPMENT

Generation of sensory hair cells by genetic programming with a combination of transcription factors

(2015) A. Costa et al.   DEVELOPMENT

Gene Expression by Mouse Inner Ear Hair Cells during Development

(2015) D. I. Scheffer et al.   JOURNAL OF NEUROSCIENCE

Spatial and Age-Dependent Hair Cell Generation in the Postnatal Mammalian Utricle

(2015) Zhen Gao et al.   MOLECULAR NEUROBIOLOGY

Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context

(2015) Israt Jahan et al.   Frontiers in Cellular Neuroscience

Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation

(2015) Jennifer Kersigo et al.   Frontiers in Aging Neuroscience

Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice

(2015) Mary Ann Cheatham et al.   PLoS One

Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo

(2014) B. C. Cox et al.   DEVELOPMENT

Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear

(2013) Kurt T. Chonko et al.   DEVELOPMENTAL BIOLOGY

The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea

(2013) Elizabeth Carroll Driver et al.   DEVELOPMENTAL BIOLOGY

Conditional Deletion of Atoh1 Reveals Distinct Critical Periods for Survival and Function of Hair Cells in the Organ of Corti

(2013) T. Cai et al.   JOURNAL OF NEUROSCIENCE

Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin

(2012) J. S. Golub et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent In Vivo Conversion of Mouse Cochlear Pillar and Deiters' Cells to Immature Hair Cells by Atoh1 Ectopic Expression

(2012) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

Atoh1 Directs the Formation of Sensory Mosaics and Induces Cell Proliferation in the Postnatal Mammalian Cochlea In Vivo

(2012) M. C. Kelly et al.   JOURNAL OF NEUROSCIENCE

Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

(2012) Omar Akil et al.   NEURON

A Novel Atoh1 “Self-Terminating” Mouse Model Reveals the Necessity of Proper Atoh1 Level and Duration for Hair Cell Differentiation and Viability

(2012) Ning Pan et al.   PLoS One

Ontogeny of Mouse Vestibulo-Ocular Reflex Following Genetic or Environmental Alteration of Gravity Sensing

(2012) Mathieu Beraneck et al.   PLoS One

Vestibular Hair Cells and Afferents: Two Channels for Head Motion Signals

(2011) Ruth Anne Eatock et al.   Annual Review of Neuroscience

Outer hair cell-specific prestin-CreERT2 knockin mouse lines

(2011) Jie Fang et al.   GENESIS

The Postnatal Accumulation of Junctional E-Cadherin Is Inversely Correlated with the Capacity for Supporting Cells to Convert Directly into Sensory Hair Cells in Mammalian Balance Organs

(2011) M. S. Collado et al.   JOURNAL OF NEUROSCIENCE

The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis

(2010) Bernd Fritzsch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Generation and characterization of Atoh1-Cre knock-in mouse line

(2010) Hua Yang et al.   GENESIS

Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion

(2010) Hua Yang et al.   GENESIS

Notch signaling and Atoh1 expression during hair cell regeneration in the mouse utricle

(2010) Guo-Peng Wang et al.   HEARING RESEARCH

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti

(2010) Ning Pan et al.   HEARING RESEARCH

Oncomodulin identifies different hair cell types in the mammalian inner ear

(2010) Dwayne D. Simmons et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment

(2010) Rachel E Hardisty-Hughes et al.   Nature Protocols

Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development

(2009) Angel C.Y. Mak et al.   GENE EXPRESSION PATTERNS

Impairment of SLC17A8 Encoding Vesicular Glutamate Transporter-3, VGLUT3, Underlies Nonsyndromic Deafness DFNA25 and Inner Hair Cell Dysfunction in Null Mice

(2008) Jérôme Ruel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spontaneous hair cell regeneration in the mouse utricle following gentamicin ototoxicity

(2008) Kohei Kawamoto et al.   HEARING RESEARCH

Vesicular Glutamate Transporter 3 Is Required for Synaptic Transmission in Zebrafish Hair Cells

(2008) N. Obholzer et al.   JOURNAL OF NEUROSCIENCE

Sensorineural Deafness and Seizures in Mice Lacking Vesicular Glutamate Transporter 3

(2008) Rebecca P. Seal et al.   NEURON

Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea

(2008) A. Dabdoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of the Mouse Utricle: Macular Organization and Hair Bundle Heights

(2007) A. Li et al.   JOURNAL OF NEUROPHYSIOLOGY