Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context

Inner ear development: building a spiral ganglion and an organ of Corti out of unspecified ectoderm

(2014) Bernd Fritzsch et al.   CELL AND TISSUE RESEARCH

Evolving gene regulatory networks into cellular networks guiding adaptive behavior: an outline how single cells could have evolved into a centralized neurosensory system

(2014) Bernd Fritzsch et al.   CELL AND TISSUE RESEARCH

LMO4 Functions As a Negative Regulator of Sensory Organ Formation in the Mammalian Cochlea

(2014) M. Deng et al.   JOURNAL OF NEUROSCIENCE

Hey1 and Hey2 Control the Spatial and Temporal Pattern of Mammalian Auditory Hair Cell Differentiation Downstream of Hedgehog Signaling

(2014) A. Benito-Gonzalez et al.   JOURNAL OF NEUROSCIENCE

Characterization of Transcriptomes of Cochlear Inner and Outer Hair Cells

(2014) H. Liu et al.   JOURNAL OF NEUROSCIENCE

bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells

(2014) Itaru Imayoshi et al.   NEURON

In Vivo Generation of Immature Inner Hair Cells in Neonatal Mouse Cochleae by Ectopic Atoh1 Expression

(2014) Zhiyong Liu et al.   PLoS One

Subunit determination of the conductance of hair-cell mechanotransducer channels

(2014) Maryline Beurg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGFR1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation

(2014) Kazuya Ono et al.   PLoS Genetics

The Genetics of Hair Cell Development and Regeneration

(2013) Andrew K. Groves et al.   Annual Review of Neuroscience

Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear

(2013) Kurt T. Chonko et al.   DEVELOPMENTAL BIOLOGY

The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea

(2013) Elizabeth Carroll Driver et al.   DEVELOPMENTAL BIOLOGY

Ectopic Expression of Activated Notch or SOX2 Reveals Similar and Unique Roles in the Development of the Sensory Cell Progenitors in the Mammalian Inner Ear

(2013) W. Pan et al.   JOURNAL OF NEUROSCIENCE

Conditional Deletion of Atoh1 Reveals Distinct Critical Periods for Survival and Function of Hair Cells in the Organ of Corti

(2013) T. Cai et al.   JOURNAL OF NEUROSCIENCE

Continued Expression of GATA3 Is Necessary for Cochlear Neurosensory Development

(2013) Jeremy S. Duncan et al.   PLoS One

A New Mutation of the Atoh1 Gene in Mice with Normal Life Span Allows Analysis of Inner Ear and Cerebellar Phenotype in Aging

(2013) Kianoush Sheykholeslami et al.   PLoS One

Coupling the cell cycle to development and regeneration of the inner ear

(2013) Thomas Schimmang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mutational ataxia resulting from abnormal vestibular acquisition and processing is partially compensated for.

(2012) Benjamin Kopecky et al.   BEHAVIORAL NEUROSCIENCE

TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1

(2012) Masatsugu Masuda et al.   DEVELOPMENTAL BIOLOGY

Eya1-Six1 Interaction Is Sufficient to Induce Hair Cell Fate in the Cochlea by Activating Atoh1 Expression in Cooperation with Sox2

(2012) Mohi Ahmed et al.   DEVELOPMENTAL CELL

Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability

(2012) Benjamin J. Kopecky et al.   DEVELOPMENTAL DYNAMICS

Transcription factors that control inner ear development and their potential for transdifferentiation and reprogramming

(2012) Thomas Schimmang   HEARING RESEARCH

Beyond generalized hair cells: Molecular cues for hair cell types

(2012) Israt Jahan et al.   HEARING RESEARCH

Atoh1, an Essential Transcription Factor in Neurogenesis and Intestinal and Inner Ear Development: Function, Regulation, and Context Dependency

(2012) Joanna Mulvaney et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Atoh1 Directs the Formation of Sensory Mosaics and Induces Cell Proliferation in the Postnatal Mammalian Cochlea In Vivo

(2012) M. C. Kelly et al.   JOURNAL OF NEUROSCIENCE

A Novel Atoh1 “Self-Terminating” Mouse Model Reveals the Necessity of Proper Atoh1 Level and Duration for Hair Cell Differentiation and Viability

(2012) Ning Pan et al.   PLoS One

Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea

(2012) Ruth R. Taylor et al.   PLoS One

Expression of Neurog1 Instead of Atoh1 Can Partially Rescue Organ of Corti Cell Survival

(2012) Israt Jahan et al.   PLoS One

Regeneration of Stereocilia of Hair Cells by Forced Atoh1 Expression in the Adult Mammalian Cochlea

(2012) Shi-Ming Yang et al.   PLoS One

Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate

(2011) K. K. Gokoffski et al.   DEVELOPMENT

Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear

(2011) Benjamin Kopecky et al.   DEVELOPMENTAL DYNAMICS

Mature Mice Lacking Rbl2/p130 Gene Have Supernumerary Inner Ear Hair Cells and Supporting Cells

(2011) S. M. Rocha-Sanchez et al.   JOURNAL OF NEUROSCIENCE

N-myc Controls Proliferation, Morphogenesis, and Patterning of the Inner Ear

(2011) E. Dominguez-Frutos et al.   JOURNAL OF NEUROSCIENCE

In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development

(2011) T. J. Klisch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation

(2010) Maxime Bouchard et al.   BMC DEVELOPMENTAL BIOLOGY

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti

(2010) Ning Pan et al.   HEARING RESEARCH

Neurod1 Suppresses Hair Cell Differentiation in Ear Ganglia and Regulates Hair Cell Subtype Development in the Cochlea

(2010) Israt Jahan et al.   PLoS One

Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear

(2010) W. Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation

(2009) Ning Pan et al.   CELL AND TISSUE RESEARCH

Hey2 Regulation by FGF Provides a Notch-Independent Mechanism for Maintaining Pillar Cell Fate in the Organ of Corti

(2009) Angelika Doetzlhofer et al.   DEVELOPMENTAL CELL

Deletion of Atoh1 Disrupts Sonic Hedgehog Signaling in the Developing Cerebellum and Prevents Medulloblastoma

(2009) A. Flora et al.   SCIENCE

Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis

(2008) David H. Nichols et al.   CELL AND TISSUE RESEARCH

Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea

(2008) A. Dabdoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA