Multiple supporting cell subtypes are capable of spontaneous hair cell regeneration in the neonatal mouse cochlea

Sox2 haploinsufficiency primes regeneration and Wnt responsiveness in the mouse cochlea

(2018) Patrick J. Atkinson et al.   JOURNAL OF CLINICAL INVESTIGATION

Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells

(2018) Melissa M. McGovern et al.   Frontiers in Cellular Neuroscience

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

(2017) Jinshu Xu et al.   Nature Communications

Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells

(2017) Will J. McLean et al.   Cell Reports

In Vivo Interplay between p27 Kip1 , GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice

(2017) Bradley J. Walters et al.   Cell Reports

Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at theAtoh1promoter

(2016) Yassan Abdolazimi et al.   DEVELOPMENT

Quantitative Analysis of Supporting Cell Subtype Labeling Among CreER Lines in the Neonatal Mouse Cochlea

(2016) Melissa M. McGovern et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice

(2016) Lingxiang Hu et al.   JOURNAL OF NEUROSCIENCE

Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea

(2016) Wenli Ni et al.   JOURNAL OF NEUROSCIENCE

Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea

(2016) Wenli Ni et al.   Oncotarget

Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea

(2016) Muhammad Waqas et al.   Oncotarget

Sox2 in the differentiation of cochlear progenitor cells

(2016) Judith S. Kempfle et al.   Scientific Reports

Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing

(2016) Juan C. Maass et al.   PLoS One

The quest for restoring hearing: Understanding ear development more completely

(2015) Israt Jahan et al.   BIOESSAYS

Where hearing starts: the development of the mammalian cochlea

(2015) Martin L. Basch et al.   JOURNAL OF ANATOMY

Selective Deletion of Cochlear Hair Cells Causes Rapid Age-Dependent Changes in Spiral Ganglion and Cochlear Nucleus Neurons

(2015) L. Tong et al.   JOURNAL OF NEUROSCIENCE

In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of  -Catenin and Atoh1

(2015) B. R. Kuo et al.   JOURNAL OF NEUROSCIENCE

Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea

(2015) Juan C. Maass et al.   Frontiers in Cellular Neuroscience

Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle

(2015) Tian Wang et al.   Nature Communications

Sox2-CreER mice are useful for fate mapping of mature, but not neonatal, cochlear supporting cells in hair cell regeneration studies

(2015) Bradley J. Walters et al.   Scientific Reports

Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo

(2014) B. C. Cox et al.   DEVELOPMENT

How to Bury the Dead: Elimination of Apoptotic Hair Cells from the Hearing Organ of the Mouse

(2014) Tommi Anttonen et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

In Vivo Generation of Immature Inner Hair Cells in Neonatal Mouse Cochleae by Ectopic Atoh1 Expression

(2014) Zhiyong Liu et al.   PLoS One

Spontaneous regeneration of cochlear supporting cells after neonatal ablation ensures hearing in the adult mouse

(2014) Marcia M. Mellado Lagarde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

(2014) Wenyan Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea

(2014) Naomi F. Bramhall et al.   Stem Cell Reports

The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea

(2013) Elizabeth Carroll Driver et al.   DEVELOPMENTAL BIOLOGY

A brief history of hair cell regeneration research and speculations on the future

(2013) Edwin W. Rubel et al.   HEARING RESEARCH

Selective Ablation of Pillar and Deiters' Cells Severely Affects Cochlear Postnatal Development and Hearing in Mice

(2013) M. M. Mellado Lagarde et al.   JOURNAL OF NEUROSCIENCE

Notch Signaling Limits Supporting Cell Plasticity in the Hair Cell-Damaged Early Postnatal Murine Cochlea

(2013) Soumya Korrapati et al.   PLoS One

Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors

(2013) Fuxin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity

(2012) Yanshu Wang et al.   CELL

Atoh1, an Essential Transcription Factor in Neurogenesis and Intestinal and Inner Ear Development: Function, Regulation, and Context Dependency

(2012) Joanna Mulvaney et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Conditional Gene Expression in the Mouse Inner Ear Using Cre-loxP

(2012) Brandon C. Cox et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Over Half the Hair Cells in the Mouse Utricle First Appear After Birth, with Significant Numbers Originating from Early Postnatal Mitotic Production in Peripheral and Striolar Growth Zones

(2012) Joseph C. Burns et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Regulation of p27Kip1 by Sox2 Maintains Quiescence of Inner Pillar Cells in the Murine Auditory Sensory Epithelium

(2012) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

Lack of Brain-Derived Neurotrophic Factor Hampers Inner Hair Cell Synapse Physiology, But Protects against Noise-Induced Hearing Loss

(2012) A. Zuccotti et al.   JOURNAL OF NEUROSCIENCE

Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin

(2012) J. S. Golub et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent In Vivo Conversion of Mouse Cochlear Pillar and Deiters' Cells to Immature Hair Cells by Atoh1 Ectopic Expression

(2012) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

Wnt-Responsive Lgr5-Expressing Stem Cells Are Hair Cell Progenitors in the Cochlea

(2012) F. Shi et al.   JOURNAL OF NEUROSCIENCE

Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea

(2012) Ruth R. Taylor et al.   PLoS One

Identification of Tympanic Border Cells as Slow-Cycling Cells in the Cochlea

(2012) Mirei Taniguchi et al.   PLoS One

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

(2012) R. Chai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p27Kip1is required to maintain proliferative quiescence in the adult cochlea and pituitary

(2011) Elizabeth C. Oesterle et al.   CELL CYCLE

Dynamic Expression of Lgr5, a Wnt Target Gene, in the Developing and Mature Mouse Cochlea

(2011) Renjie Chai et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Supporting Cell Division Is Not Required for Regeneration of Auditory Hair Cells After Ototoxic Injury In Vitro

(2010) Jialin Shang et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

In Vivo Proliferation of Postmitotic Cochlear Supporting Cells by Acute Ablation of the Retinoblastoma Protein in Neonatal Mice

(2010) Y. Yu et al.   JOURNAL OF NEUROSCIENCE

Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression

(2010) M. E. Gomez-Casati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development

(2009) Angel C.Y. Mak et al.   GENE EXPRESSION PATTERNS

Cell-Specific Inducible Gene Recombination in Postnatal Inner Ear Supporting Cells and Glia

(2009) María Eugenia Gómez-Casati et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea

(2009) Fu-Quan Chen et al.   JOURNAL OF NEUROCHEMISTRY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

 II- V spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells

(2008) K. Legendre et al.   JOURNAL OF CELL SCIENCE

Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea

(2008) A. Dabdoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

(2008) B. Abrahamsen et al.   SCIENCE