Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity

Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression

(2023) Alessia Gravina et al.   NATURE BIOTECHNOLOGY

Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques

(2023) Xiaomeng Hu et al.   NATURE BIOTECHNOLOGY

Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice

(2023) Xiaomeng Hu et al.   Science Translational Medicine

Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice

(2023) Xiaomeng Hu et al.   Nature Communications

The SIRPα–CD47 immune checkpoint in NK cells

(2021) Tobias Deuse et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

(2021) Shoichi Iriguchi et al.   Nature Communications

Will allogeneic CAR T cells for CD19+ malignancies take autologous CAR T cells ‘off the shelf’?

(2021) Amanda M. DiNofia et al.   Nature Reviews Clinical Oncology

Navigating CAR-T cells through the solid-tumour microenvironment

(2021) Andrew J. Hou et al.   NATURE REVIEWS DRUG DISCOVERY

Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells

(2021) Bo Wang et al.   Nature Biomedical Engineering

Incorporation of bacterial immunoevasins to protect cell therapies from host antibody-mediated immune rejection

(2021) Leila Peraro et al.   MOLECULAR THERAPY

Generation of insulin-producing pancreatic β cells from multiple human stem cell lines

(2021) Nathaniel J. Hogrebe et al.   Nature Protocols

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

A Stem Cell Approach to Cure Type 1 Diabetes

(2020) Aharon Helman et al.   Cold Spring Harbor Perspectives in Biology

Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains

(2020) Norris Lam et al.   Nature Communications

The H-Y Antigen in Embryonic Stem Cells causes rejection in syngeneic female recipients

(2020) Xiaomeng Hu et al.   STEM CELLS AND DEVELOPMENT

Immune-evasive human islet-like organoids ameliorate diabetes

(2020) Eiji Yoshihara et al.   NATURE

Exploring the NK cell platform for cancer immunotherapy

(2020) Jacob A. Myers et al.   Nature Reviews Clinical Oncology

Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies

(2020) Reuben Benjamin et al.   LANCET

Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs

(2019) Ruchi Sharma et al.   Science Translational Medicine

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

(2019) Huaigeng Xu et al.   Cell Stem Cell

Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma

(2019) Jie Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Tim-3 and its role in regulating anti-tumor immunity

(2017) Madhumita Das et al.   IMMUNOLOGICAL REVIEWS

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

MHC matching improves engraftment of iPSC-derived neurons in non-human primates

(2017) Asuka Morizane et al.   Nature Communications

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

(2017) Kristen M. Hege et al.   Journal for ImmunoTherapy of Cancer

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

(2016) Cameron J. Turtle et al.   JOURNAL OF CLINICAL INVESTIGATION

Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

(2016) Yuji Shiba et al.   NATURE

Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates

(2016) Takuji Kawamura et al.   Stem Cell Reports

Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models

(2016) Sunao Sugita et al.   Stem Cell Reports

SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts

(2015) Tobias Deuse et al.   Cell Stem Cell

A future with less HLA: potential clinical applications of HLA-universal cells

(2015) C. Figueiredo et al.   TISSUE ANTIGENS

CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy

(2014) D. R. Soto-Pantoja et al.   CANCER RESEARCH

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

(2014) Yu-Hwa Huang et al.   NATURE

Heterelogous expression of mutated HLA-G decreases immunogenicity of human embryonic stem cells and their epidermal derivatives

(2014) Longmei Zhao et al.   Stem Cell Research

A Novel Soluble Form of Tim-3 Associated with Severe Graft-versus-Host Disease

(2013) John A. Hansen et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation

(2013) Toshinobu Nishimura et al.   Cell Stem Cell

A Disintegrin and Metalloprotease (ADAM) 10 and ADAM17 Are Major Sheddases of T Cell Immunoglobulin and Mucin Domain 3 (Tim-3)

(2013) Katja Möller-Hackbarth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity

(2012) L. C. Ndhlovu et al.   BLOOD

Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in Humans

(2010) Michael C. Jensen et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells

(2010) C. H. J. Lamers et al.   BLOOD

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

(2010) D. M. Benson et al.   BLOOD

Signal Regulatory Proteins (SIRPS) Are Secreted Presynaptic Organizing Molecules

(2008) Hisashi Umemori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY