A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods

(2023) Felix Bayerl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

(2023) Felix Bayerl et al.   IMMUNITY

Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning

(2022) Caroline Weis et al.   NATURE MEDICINE

‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses

(2022) Dietmar Zehn et al.   NATURE IMMUNOLOGY

Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies

(2022) Jana Lipkova et al.   NATURE MEDICINE

Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy

(2022) Tobias Hoch et al.   Science Immunology

CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

(2022) Nataliya Prokhnevska et al.   IMMUNITY

Significance of monocyte infiltration in patients with gastric cancer: A combined study based on single cell sequencing and TCGA

(2022) Wei Xu et al.   Frontiers in Oncology

Dendritic Cells Revisited

(2021) Mar Cabeza-Cabrerizo et al.   Annual Review of Immunology

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

(2021) Sijin Cheng et al.   CELL

CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

(2021) Mauro Di Pilato et al.   CELL

A guide to machine learning for biologists

(2021) Joe G. Greener et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity

(2021) Ghita Ghislat et al.   Science Immunology

Discovering dominant tumor immune archetypes in a pan-cancer census

(2021) Alexis J. Combes et al.   CELL

Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

(2021) Ellen Duong et al.   IMMUNITY

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer

(2020) Margaux Hubert et al.   Science Immunology

cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

(2020) Stephen T. Ferris et al.   NATURE

glmGamPoi: Fitting Gamma-Poisson Generalized Linear Models on Single Cell Count Data

(2020) Constantin Ahlmann-Eltze et al.   BIOINFORMATICS

Development of a macrophages-related 4-gene signature and nomogram for the overall survival prediction of hepatocellular carcinoma based on WGCNA and LASSO algorithm

(2020) Zichang Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

(2019) Sema Kurtulus et al.   IMMUNITY

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

(2019) Imran Siddiqui et al.   IMMUNITY

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

(2019) Melvyn T. Chow et al.   IMMUNITY

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

(2019) Denarda Dangaj et al.   CANCER CELL

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

(2019) David Liu et al.   NATURE MEDICINE

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific

(2018) Paula Michea et al.   NATURE IMMUNOLOGY

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer

(2018) Charles S. Fuchs et al.   JAMA Oncology

Deep learning in biomedicine

(2018) Michael Wainberg et al.   NATURE BIOTECHNOLOGY

Clinically applicable deep learning for diagnosis and referral in retinal disease

(2018) Jeffrey De Fauw et al.   NATURE MEDICINE

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

A guide to deep learning in healthcare

(2018) Andre Esteva et al.   NATURE MEDICINE

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions

(2015) Sarah Eickhoff et al.   CELL

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Deep learning

(2015) Yann LeCun et al.   NATURE

Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints

(2015) M. E. Mikucki et al.   Nature Communications

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

(2015) A. R. Sanchez-Paulete et al.   Cancer Discovery

Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue

(2014) Hai Qi et al.   Annual Review of Cell and Developmental Biology

Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow

(2014) C. T. Mayer et al.   BLOOD

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node

(2013) Wolfgang Kastenmüller et al.   IMMUNITY

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1

(2013) C. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Bright Fluorescence Monitoring System Utilizing Zoanthus sp. Green Fluorescent Protein (ZsGreen) for Human G-Protein-Coupled Receptor Signaling in Microbial Yeast Cells

(2013) Yasuyuki Nakamura et al.   PLoS One

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens

(2010) Kenichi Asano et al.   IMMUNITY

GFP-like Proteins Stably Accumulate in Lysosomes

(2008) Hiroyuki Katayama et al.   CELL STRUCTURE AND FUNCTION

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE