LepR+ niche cell–derived AREG compromises hematopoietic stem cell maintenance under conditions of DNA repair deficiency and aging

Focal Point of Fanconi Anemia Signaling

(2021) Sudong Zhan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epidermal growth factor receptor-dependent DNA repair promotes murine and human hematopoietic regeneration

(2020) Tiancheng Fang et al.   BLOOD

Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis

(2020) Jung Hwa Ko et al.   Cell Reports

Persistent DNA damage–induced NLRP12 improves hematopoietic stem cell function

(2020) Qiqi Lin et al.   JCI Insight

A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation

(2019) Carlos M. Minutti et al.   IMMUNITY

Upregulation of AREG, EGFR, and HER2 contributes to increased VEGF expression in granulosa cells of patients with OHSS†

(2019) Lanlan Fang et al.   BIOLOGY OF REPRODUCTION

How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?

(2019) Ashok R. Venkitaraman   DNA REPAIR

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression

(2019) Qixia Xu et al.   AGING CELL

Niches for Hematopoietic Stem Cells and Their Progeny

(2018) Qiaozhi Wei et al.   IMMUNITY

Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

(2018) Michael Koeppen et al.   Nature Communications

Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration

(2018) Heather A. Himburg et al.   Cell Stem Cell

Aging alters the epigenetic asymmetry of HSC division

(2018) M. Carolina Florian et al.   PLOS BIOLOGY

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

(2018) Mati Mann et al.   Cell Reports

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

Aging of hematopoietic stem cells: DNA damage and mutations?

(2016) Bettina M. Moehrle et al.   EXPERIMENTAL HEMATOLOGY

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging

(2016) Kira Young et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion

(2016) W Du et al.   LEUKEMIA

Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms

(2016) Heather A Himburg et al.   NATURE MEDICINE

Hyper-active non-homologous end joining selects for synthetic lethality resistant and pathological Fanconi anemia hematopoietic stem and progenitor cells

(2016) Wei Du et al.   Scientific Reports

DNA Damage Response in Hematopoietic Stem Cell Ageing

(2016) Tangliang Li et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

(2015) Nicola K. Wilson et al.   Cell Stem Cell

Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair

(2015) Dietmar M.W. Zaiss et al.   IMMUNITY

Basophil-Derived Amphiregulin Is Essential for UVB Irradiation–Induced Immune Suppression

(2015) Chantal Meulenbroeks et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hepatic CD206-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection

(2015) Kai Dai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

(2015) Bo O Zhou et al.   eLife

Stress and DNA repair biology of the Fanconi anemia pathway

(2014) S. Longerich et al.   BLOOD

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Amphiregulin

(2014) Carmen Berasain et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Association between ERCC1 and XPA expression and polymorphisms and the response to cisplatin in testicular germ cell tumours

(2013) J Mendoza et al.   BRITISH JOURNAL OF CANCER

Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

(2013) Chacko Joseph et al.   Cell Stem Cell

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

(2013) Dietmar M.W. Zaiss et al.   IMMUNITY

Fanconi anaemia,BRCA2mutations and childhood cancer: a developmental perspective from clinical and epidemiological observations with implications for genetic counselling

(2013) Stefan Meyer et al.   JOURNAL OF MEDICAL GENETICS

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment

(2013) Britta Will et al.   NATURE IMMUNOLOGY

Epidermal growth factor regulates hematopoietic regeneration after radiation injury

(2013) Phuong L Doan et al.   NATURE MEDICINE

Aberrantly activated AREG–EGFR signaling is required for the growth and survival of CRTC1–MAML2 fusion-positive mucoepidermoid carcinoma cells

(2013) Z Chen et al.   ONCOGENE

An acute negative bystander effect of  -irradiated recipients on transplanted hematopoietic stem cells

(2012) H. Shen et al.   BLOOD

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Maintenance of genomic integrity in hematopoietic stem cells

(2011) Kazuhito Naka et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

(2011) Shichuan Zhang et al.   JOURNAL OF CELL BIOLOGY

Human Keratinocytes' Response to Injury Upregulates CCL20 and Other Genes Linking Innate and Adaptive Immunity

(2011) Milène Kennedy-Crispin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Unraveling the mechanism of BRCA2 in homologous recombination

(2011) William K Holloman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis

(2010) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway

(2009) J O Humtsoe et al.   ONCOGENE

Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease Progression

(2008) Wei Du et al.   ANTIOXIDANTS & REDOX SIGNALING