Assessing the dynamics and macromolecular interactions of the intrinsically disordered protein YY1

YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6

(2023) Saisai Chen et al.   Journal for ImmunoTherapy of Cancer

A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters

(2022) Wenmeng Wang et al.   NUCLEIC ACIDS RESEARCH

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

(2022) Tsung-Han S. Hsieh et al.   NATURE GENETICS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

IUPred3: prediction of protein disorder enhanced with unambiguous experimental annotation and visualization of evolutionary conservation

(2021) Gábor Erdős et al.   NUCLEIC ACIDS RESEARCH

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

(2021) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

The Why of YY1: Mechanisms of Transcriptional Regulation by Yin Yang 1

(2020) Thijs C. J. Verheul et al.   Frontiers in Cell and Developmental Biology

Supramolecular Fuzziness of Intracellular Liquid Droplets: Liquid–Liquid Phase Transitions, Membrane-Less Organelles, and Intrinsic Disorder

(2019) Vladimir N. Uversky   MOLECULES

The Two Sides of YY1 in Cancer: A Friend and a Foe

(2019) Sailu Sarvagalla et al.   Frontiers in Oncology

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders

(2018) Sara B Estruch et al.   HUMAN MOLECULAR GENETICS

A Phosphomimetic Study Implicates Ser557 in Regulation of FOXP2 DNA Binding

(2018) Ashleigh Blane et al.   PROTEIN JOURNAL

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

CNTNAP2 is a direct FoxP2 target in vitro and in vivo in zebra finches: complex regulation by age and activity

(2017) I. Adam et al.   GENES BRAIN AND BEHAVIOR

Nuclear speckles: molecular organization, biological function and role in disease

(2017) Lukasz Galganski et al.   NUCLEIC ACIDS RESEARCH

A Key Evolutionary Mutation Enhances DNA Binding of the FOXP2 Forkhead Domain

(2016) Gavin Morris et al.   BIOCHEMISTRY

Functional characterization of rare FOXP2 variants in neurodevelopmental disorder

(2016) Sara B. Estruch et al.   Journal of Neurodevelopmental Disorders

Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson’s disease

(2016) Rishi Pal et al.   NEUROLOGICAL RESEARCH

The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity

(2016) Dorothy C.C. Wai et al.   NUCLEIC ACIDS RESEARCH

Effect of pH on the Structure and DNA Binding of the FOXP2 Forkhead Domain

(2015) Ashleigh Blane et al.   BIOCHEMISTRY

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

(2015) Jianwei Wang et al.   BMC CANCER

Intrinsic disorder of human Yin Yang 1 protein

(2015) Andrzej Górecki et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression

(2015) Soline Aubry et al.   PLoS One

Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases

(2014) Andrés López-Perrote et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variants of the CNTNAP2 5′ promoter as risk factors for autism spectrum disorders: a genetic and functional approach

(2014) A G Chiocchetti et al.   MOLECULAR PSYCHIATRY

MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins

(2012) Fatemeh Miri Disfani et al.   BIOINFORMATICS

An investigation of the affinities, specificity and kinetics involved in the interaction between the Yin Yang 1 transcription factor and DNA

(2012) Filip M. Golebiowski et al.   FEBS Journal

Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding

(2012) Wei-Lun Hsu et al.   PROTEIN SCIENCE

YY1 Tethers Xist RNA to the Inactive X Nucleation Center

(2011) Yesu Jeon et al.   CELL

A view of nuclear Polycomb bodies

(2011) Vincenzo Pirrotta et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Efficient overexpression and purification of active full-length human transcription factor Yin Yang 1 in Escherichia coli

(2011) Filip M. Golebiowski et al.   PROTEIN EXPRESSION AND PURIFICATION

De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment

(2010) Fadi F. Hamdan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

PcG recruitment by the YY1 REPO domain can be mediated by Yaf2

(2009) Frank Wilkinson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cellular factor YY1 downregulates the human papillomavirus 16 E6/E7 promoter, P97, in vivo and in vitro from a negative element overlapping the transcription-initiation site

(2009) M. J. Lace et al.   JOURNAL OF GENERAL VIROLOGY

Human-specific transcriptional regulation of CNS development genes by FOXP2

(2009) Genevieve Konopka et al.   NATURE

FOXP2 as a molecular window into speech and language

(2009) Simon E. Fisher et al.   TRENDS IN GENETICS

Genome-Wide Analysis of Histidine Repeats Reveals Their Role in the Localization of Human Proteins to the Nuclear Speckles Compartment

(2009) Eulàlia Salichs et al.   PLoS Genetics

NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

(2008) Huating Wang et al.   CANCER CELL

The Yin and Yang of YY1 in the nervous system

(2008) Ye He et al.   JOURNAL OF NEUROCHEMISTRY