The Two Sides of YY1 in Cancer: A Friend and a Foe

miR‑544 inhibits the migration and invasion of anaplastic thyroid cancer by targeting Yin Yang‑1

(2019) Feng Wang et al.   Oncology Letters

Regulation of Krüppel-Like Factor 4 (KLF4) expression through the transcription factor Yin-Yang 1 (YY1) in non-Hodgkin B-cell lymphoma

(2019) Mario Morales-Martinez et al.   Oncotarget

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer

(2019) Weimei Tang et al.   Nature Communications

FAM3C‐YY1 axis is essential for TGFβ‐promoted proliferation and migration of human breast cancer MDA‐MB‐231 cells via the activation of HSF1

(2019) Weili Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT

(2019) Guoqing Zhu et al.   CARCINOGENESIS

YY1 complex promotes Quaking expression via super-enhancer binding during EMT of hepatocellular carcinoma

(2019) Jingxia Han et al.   CANCER RESEARCH

Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation

(2019) Sandra Varum et al.   Cell Stem Cell

MicroRNA‐520c‐3p functions as a novel tumor suppressor in lung adenocarcinoma

(2019) Xiaofeng Li et al.   FEBS Journal

RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme

(2019) Michael R. Waters et al.   Oncogenesis

YY1-Induced Upregulation of Long Noncoding RNA ARAP1-AS1 Promotes Cell Migration and Invasion in Colorectal Cancer Through the Wnt/β-Catenin Signaling Pathway

(2019) Yaqun Ye et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

miR‐5590‐3p‐YY1 feedback loop promotes the proliferation and migration of triple‐negative breast cancer cells

(2019) Feng Liang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HnRNPM is a potential mediator of YY1 which promotes EMT in prostate cancer cells

(2019) Tong Yang et al.   PROSTATE

Functional interplay between YY1 and CARM1 promotes oral carcinogenesis

(2019) Amit K. Behera et al.   Oncotarget

YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma

(2019) Jing Du et al.   MOLECULAR CARCINOGENESIS

MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer

(2019) Xiao Lu et al.   ONCOGENE

YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway

(2019) Qun Chen et al.   CANCER LETTERS

Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3

(2018) Yali Wang et al.   CANCER SCIENCE

The Yin and Yang of YY1 in tumor growth and suppression

(2018) Levon M. Khachigian   INTERNATIONAL JOURNAL OF CANCER

Role of Yin Yang-1 (YY1) in the transcription regulation of the multi-drug resistance (MDR1) gene

(2018) Gabriela Antonio-Andrés et al.   LEUKEMIA & LYMPHOMA

miR‑29a suppresses IL‑13‑induced cell invasion by inhibiting YY1 in the AKT pathway in lung adenocarcinoma A549 cells

(2018) Yu Zhang et al.   ONCOLOGY REPORTS

Expression of Yin Yang 1 in cervical cancer and its correlation with E-cadherin expression and HPV16 E6

(2018) Wanxue Wang et al.   PLoS One

Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy

(2018) Silvina Odete Bustos et al.   Oncotarget

YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells

(2018) Jia Wang et al.   Stem Cell Reports

Spleen tyrosine kinase SYK(L) interacts with YY1 and coordinately suppresses SNAI2 transcription in lung cancer cells

(2018) Dan Gao et al.   FEBS Journal

YY1 binds to the E3ʹ enhancer and inhibits the expression of the immunoglobulin κ gene via epigenetic modifications

(2018) Xiaorong Zhou et al.   IMMUNOLOGY

MiR-141-3p Suppresses Tumor Growth and Metastasis in Papillary Thyroid Cancer via Targeting Yin Yang 1

(2018) Ming Fang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

YY1 negatively regulates the XAF1 gene expression in prostate cancer

(2018) B. Camacho-Moctezuma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of YY1 OPB Peptide for Its Anticancer Activity

(2018) Yige Qi et al.   CURRENT CANCER DRUG TARGETS

miR-186 reverses cisplatin resistance and inhibits the�formation of the glioblastoma-initiating cell�phenotype by degrading Yin Yang 1 in glioblastoma

(2018) Jian Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein

(2018) Xi Shen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

YY1 suppresses proliferation and migration of pancreatic ductal adenocarcinoma by regulating the CDKN3/MdM2/P53/P21 signaling pathway

(2017) Dongfang Liu et al.   INTERNATIONAL JOURNAL OF CANCER

CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis

(2017) Charalabos Pothoulakis et al.   INTERNATIONAL JOURNAL OF CANCER

Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer

(2017) Yeqing Huang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells

(2017) Chuang Yang et al.   Journal of Translational Medicine

miR‑218 inhibits the proliferation of human glioma cells through downregulation of Yin Yang 1

(2017) Yong Gao et al.   Molecular Medicine Reports

The YY1-HOTAIR-MMP2 Signaling Axis Controls Trophoblast Invasion at the Maternal-Fetal Interface

(2017) Yan Zhang et al.   MOLECULAR THERAPY

miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78

(2017) Chengyan Luo et al.   ONCOLOGY RESEARCH

miRNA-186 inhibits prostate cancer cell proliferation and tumor growth by targeting YY1 and CDK6

(2017) Shu Lu et al.   Experimental and Therapeutic Medicine

YY1 promotes HDAC1 expression and decreases sensitivity of hepatocellular carcinoma cells to HDAC inhibitor

(2017) Sheng Dong et al.   Oncotarget

Identification of Transcription Factor YY1 as a Regulator of a Prostate Cancer-Specific Pathway Using Proteomic Analysis

(2017) Arum Park et al.   Journal of Cancer

The Metabolic Phenotype of Prostate Cancer

(2017) Eric Eidelman et al.   Frontiers in Oncology

MicroRNA-215 suppresses cell proliferation, migration and invasion of colon cancer by repressing Yin-Yang 1

(2016) Zehong Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

(2016) Peng Yuan et al.   CANCER RESEARCH

The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface

(2016) Fu-Ju Tian et al.   JOURNAL OF PATHOLOGY

Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma

(2016) Daisy PF Tsang et al.   JOURNAL OF PATHOLOGY

YY1 plays an essential role at all stages of B-cell differentiation

(2016) Eden Kleiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-29a promotes smooth muscle cell differentiation from stem cells by targeting YY1

(2016) Min Jin et al.   Stem Cell Research

Yin Yang-1 increases apoptosis through Bax activation in pancreatic cancer cells

(2016) Jing-Jing Zhang et al.   Oncotarget

SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells

(2016) Jungsug Gwak et al.   Oncotarget

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

(2015) Jianwei Wang et al.   BMC CANCER

Expression of YY1 in Differentiated Thyroid Cancer

(2015) Jéssica Arribas et al.   ENDOCRINE PATHOLOGY

YY1 regulates melanoma tumorigenesis through a miR-9 ~ RYBP axis

(2015) Guowei Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression

(2015) WEN-YU ZHOU et al.   Molecular Medicine Reports

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes

(2015) Lillianne G. Harris et al.   NUCLEIC ACIDS RESEARCH

Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM+ AFP+ hepatocellular carcinoma

(2015) X Zhao et al.   ONCOGENE

Intrinsic disorder of human Yin Yang 1 protein

(2015) Andrzej Górecki et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IL-13 receptor α2 is a negative prognostic factor in human lung cancer and stimulates lung cancer growth in mice

(2015) Mian Xie et al.   Oncotarget

IL-13 Induces YY1 through the AKT Pathway in Lung Fibroblasts

(2015) Jia Guo et al.   PLoS One

miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway

(2014) Yan Cheng et al.   FEBS LETTERS

Overexpression of Yin Yang 1 in bone marrow-derived human multiple myeloma and its clinical significance

(2014) SARA HUERTA-YEPEZ et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of Yin Yang 1-Dependent Repressor Activity of DR5 Transcription and Expression by the Novel Proteasome Inhibitor NPI-0052 Contributes to its TRAIL-Enhanced Apoptosis in Cancer Cells

(2014) Stavroula Baritaki et al.   JOURNAL OF IMMUNOLOGY

Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism

(2014) Jing-Jing Zhang et al.   Molecular Cancer

A prominent and conserved role for YY1 in Xist transcriptional activation

(2014) Mélanie Makhlouf et al.   Nature Communications

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus

(2013) Xuan Pan et al.   EMBO JOURNAL

Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements

(2013) C. Alfieri et al.   GENES & DEVELOPMENT

CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia

(2013) Ye Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome

(2013) Harriet E Sandison et al.   JOURNAL OF CLINICAL PATHOLOGY

Molecular Dissection of AKT Activation in Lung Cancer Cell Lines

(2013) Yanan Guo et al.   MOLECULAR CANCER RESEARCH

YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment

(2013) Arindam Basu et al.   NUCLEIC ACIDS RESEARCH

Transcriptional Repression of Bim by a Novel YY1-RelA Complex Is Essential for the Survival and Growth of Multiple Myeloma

(2013) Veena Potluri et al.   PLoS One

O-GlcNAcylation: A New Cancer Hallmark?

(2013) Yann Fardini et al.   Frontiers in Endocrinology

Yin Yang 1 Plays an Essential Role in Breast Cancer and Negatively Regulates p27

(2012) Meimei Wan et al.   AMERICAN JOURNAL OF PATHOLOGY

A Novel Target of MicroRNA-29, Ring1 and YY1-binding Protein (Rybp), Negatively Regulates Skeletal Myogenesis

(2012) Liang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of DU145 prostate cancer cell growth by Scm-like with four mbt domains 2

(2012) Kwanghyun Lee et al.   JOURNAL OF BIOSCIENCES

Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

(2012) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Galiximab Signals B-NHL Cells and Inhibits the Activities of NF- B-Induced YY1- and Snail-Resistant Factors: Mechanism of Sensitization to Apoptosis by Chemoimmunotherapeutic Drugs

(2012) M. A. Martinez-Paniagua et al.   MOLECULAR CANCER THERAPEUTICS

microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis

(2012) N Zhang et al.   ONCOGENE

Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis

(2011) Melisa A. Martínez-Paniagua et al.   CELL CYCLE

YY1 Is a Novel Potential Therapeutic Target for the Treatment of HPV Infection-Induced Cervical Cancer by Arsenic Trioxide

(2011) Guifen He et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-Snail1 pathway in melanoma

(2011) Shujing Liu et al.   JOURNAL OF PATHOLOGY

Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation

(2011) M-H Lee et al.   ONCOGENE

Hepatitis B virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells

(2011) Lei Zhang et al.   VIRUS RESEARCH

KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma

(2010) H. Guan et al.   BLOOD

Yin Yang 1 overexpression in diffuse large B-cell lymphoma is associated with B-cell transformation and tumor progression

(2010) Giancarlo Castellano et al.   CELL CYCLE

TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like

(2010) Jakub Siednienko et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis

(2010) Greta Forlani et al.   HUMAN MOLECULAR GENETICS

Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-κB/Snail/YY1/RKIP circuitry

(2010) Benjamin Bonavida et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer

(2010) N. N. Yokoyama et al.   NUCLEIC ACIDS RESEARCH

YY1 is autoregulated through its own DNA-binding sites

(2009) Jeong Kim et al.   BMC MOLECULAR BIOLOGY

YY1 Over-Expression in Human Brain Gliomas and Meningiomas Correlates with TGF-β1, IGF-1 and FGF-2 mRNA Levels

(2009) Stavroula Baritaki et al.   CANCER INVESTIGATION

PcG recruitment by the YY1 REPO domain can be mediated by Yaf2

(2009) Frank Wilkinson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adenovirus Transforming Protein E1A Induces c-Myc in Quiescent Cells by a Novel Mechanism

(2009) R.-K. Kadeppagari et al.   JOURNAL OF VIROLOGY

Yin Yang 1 Regulates the Expression of Snail through a Distal Enhancer

(2009) M. B. Palmer et al.   MOLECULAR CANCER RESEARCH

Yin Yang 1 regulates the transcriptional activity of androgen receptor

(2009) Z Deng et al.   ONCOGENE

Genome-Wide Analysis of Histidine Repeats Reveals Their Role in the Localization of Human Proteins to the Nuclear Speckles Compartment

(2009) Eulàlia Salichs et al.   PLoS Genetics

YY1 restrained cell senescence through repressing the transcription of p16

(2008) Xiuli Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer

(2008) Mads Thomassen et al.   BMC CANCER

NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

(2008) Huating Wang et al.   CANCER CELL

In vivo Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors

(2008) R. Snoek et al.   CLINICAL CANCER RESEARCH

Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers

(2008) Guoling Ren et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epigenetic Silencing of CCAAT/Enhancer-binding Protein δ Activity by YY1/Polycomb Group/DNA Methyltransferase Complex

(2008) Chiung-Yuan Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yin Yang 1 Is a Critical Repressor of Matrix Metalloproteinase-9 Expression in Brain Neurons

(2008) Marcin Rylski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Yin and Yang of YY1 in the nervous system

(2008) Ye He et al.   JOURNAL OF NEUROCHEMISTRY

YY1 Protects Cardiac Myocytes from Pathologic Hypertrophy by Interacting with HDAC5

(2008) Carmen C. Sucharov et al.   MOLECULAR BIOLOGY OF THE CELL

p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc

(2008) N Sankar et al.   ONCOGENE

A SAP30 Complex Inhibits IFN-β Expression in Rift Valley Fever Virus Infected Cells

(2008) Nicolas Le May et al.   PLoS Pathogens

The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes

(2007) Hui Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY