Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological evaluation and molecular modeling studies

Cytotoxic and chemomodulatory effects of Phyllanthus niruri in MCF-7 and MCF-7ADR breast cancer cells

(2023) Ola E. Abdel-Sattar et al.   Scientific Reports

Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment

(2021) Adel A. Marzouk et al.   BIOORGANIC CHEMISTRY

Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review

(2021) Juan Antonio Giménez-Bastida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and X-ray crystal structure of unexpected novel thiazolidinone/1,3,4-thiadiazole heterocycle via S-alkylation and Smiles rearrangement dual approaches

(2021) Abdullah Mohammed Al-Majid et al.   JOURNAL OF MOLECULAR STRUCTURE

New quinoline/1,2,4-triazole hybrids as dual inhibitors of COX-2/5-LOX and inflammatory cytokines: Design, synthesis, and docking study

(2021) Aliaa M. Mohassab et al.   JOURNAL OF MOLECULAR STRUCTURE

Inhibition of Caco-2 and MCF-7 cancer cells using chalcones: synthesis, biological evaluation and computational study

(2021) Marco Mellado et al.   NATURAL PRODUCT RESEARCH

1,2,4-Triphenylpyrroles: Synthesis, Structure and Luminescence Properties

(2020) Joana R. M. Ferreira et al.   SYNLETT

Discovery of new fluorescent thiazole–pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells

(2020) ZhaoMin Lin et al.   Cell Death & Disease

Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies

(2020) Abdallah M. Alfayomy et al.   BIOORGANIC CHEMISTRY

An Overview of Scoring Functions Used for Protein–Ligand Interactions in Molecular Docking

(2019) Jin Li et al.   Interdisciplinary Sciences-Computational Life Sciences

Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones

(2019) Perihan A. Elzahhar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES

(2019) Ghaneya S. Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals

(2019) Kalpesh R. Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of some novel pyrazoline‐thiazole hybrids and their antimicrobial activities

(2019) Doaa M. Masoud et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids

(2019) Hajjaj H.M. Abdu-Allah et al.   BIOORGANIC CHEMISTRY

Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties

(2019) Aya E. Ghonim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of new prodrugs of etodolac and tolfenamic acid with reduced ulcerogenic potential

(2019) Sonia T. Hassib et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Non-acidic 1,3,4-trisubstituted-pyrazole derivatives as lonazolac analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile

(2018) Khaled R.A. Abdellatif et al.   BIOORGANIC CHEMISTRY

Thiazoles and Thiazolidinones as COX/LOX Inhibitors

(2018) et al.   MOLECULES

Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study

(2017) Phoebe F. Lamie et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new pyrazolylthiazole derivatives

(2017) Murtaza Madni et al.   MEDICINAL CHEMISTRY RESEARCH

COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles

(2017) Smaranda Oniga et al.   MOLECULES

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives

(2016) Pavan Srivastava et al.   BIOORGANIC CHEMISTRY

Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

(2016) Eman K.A. Abdelall et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Pharmacology of Indomethacin

(2016) Sylvia Lucas   HEADACHE

Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition

(2016) Han-Yue Qiu et al.   PHARMACOLOGICAL RESEARCH

Synthesis of novel thiazolylpyrazoline derivatives and evaluation of their antimicrobial activities and cytotoxicities

(2016) Aouatef TABBI et al.   TURKISH JOURNAL OF CHEMISTRY

Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase

(2016) Yu Zhou et al.   Acta Pharmaceutica Sinica B

Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents

(2015) Jiqiang He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

(2015) Rajeshwary Ghosh et al.   Oxidative Medicine and Cellular Longevity

Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis

(2015) Vishnu Nayak Badavath et al.   ACS Medicinal Chemistry Letters

New insights into the use of currently available non-steroidal anti-inflammatory drugs

(2015) Brune et al.   Journal of Pain Research

Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: Identification of a lead for anti-inflammatory drug

(2014) Shaveta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CC Cross-Coupling of Primary and Secondary Benzylic Alcohols Using Supported Gold-Based Bimetallic Catalysts

(2013) Xiang Liu et al.   ChemSusChem

Synthesis and Anticancer and Antiviral Activities of New 2-Pyrazoline-Substituted 4-Thiazolidinones

(2013) Dmytro Havrylyuk et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Benzenesulfonamide bearing pyrazolylpyrazolines: synthesis and evaluation as anti-inflammatory–antimicrobial agents

(2013) Pawan Kumar et al.   MEDICINAL CHEMISTRY RESEARCH

Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease

(2013) Clara M. Yates et al.   PHARMACOLOGY & THERAPEUTICS

Principles for Valid Histopathologic Scoring in Research

(2013) K. N. Gibson-Corley et al.   VETERINARY PATHOLOGY

Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors

(2012) Ke-Ming Qiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents

(2012) I. Apostolidis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fragment-based design, docking, synthesis, biological evaluation and structure–activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors

(2011) Phaedra Eleftheriou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors

(2010) Rossella Fioravanti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide

(2008) I.G. Rathish et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Computer-Aided Discovery of Anti-Inflammatory Thiazolidinones with Dual Cyclooxygenase/Lipoxygenase Inhibition

(2008) Athina A. Geronikaki et al.   JOURNAL OF MEDICINAL CHEMISTRY