Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review

A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediators

(2021) Mehmet Yabas et al.   Frontiers in Immunology

New Insights into the Metabolism of the Flavanones Eriocitrin and Hesperidin: A Comparative Human Pharmacokinetic Study

(2021) María Ángeles Ávila-Gálvez et al.   Antioxidants

Disposition of Dietary Polyphenols in Breast Cancer Patients’ Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin

(2021) María Ángeles Ávila‐Gálvez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

(2021) Matthew J. Page et al.   PLOS MEDICINE

Multidimensional Impact of Mediterranean Diet on IBD Patients

(2020) Fabio Chicco et al.   INFLAMMATORY BOWEL DISEASES

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

(2020) Adrián Cortés‐Martín et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of 5‐Lipoxygenase‐Derived Leukotrienes and Hemiketals as a Novel Anti‐Inflammatory Mechanism of Urolithins

(2020) Juan Antonio Giménez‐Bastida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt

(2020) Eman S. Habib et al.   NATURAL PRODUCT RESEARCH

Eicosanoids

(2020) Philip C. Calder   Essays in Biochemistry

Chemical Composition of Pterospermum heterophyllum Root and its Anti-Arthritis Effect on Adjuvant-Induced Arthritis in Rats via Modulation of Inflammatory Responses

(2020) Li Yang et al.   Frontiers in Pharmacology

Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats

(2020) Li Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Treatment with either COX ‐2 inhibitor or 5‐ LOX inhibitor causes no compensation between COX ‐2 pathway and 5‐ LOX pathway in chronic aluminum overload‐induced liver injury in rats

(2019) Hui Xia et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Regulation and Functions of 15-Lipoxygenases in Human Macrophages

(2019) Ryan G. Snodgrass et al.   Frontiers in Pharmacology

Dietary Curcumin: Correlation between Bioavailability and Health Potential

(2019) Michele Dei Cas et al.   Nutrients

Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-κB/TNF-α/NOX/iNOS Pathway

(2019) Sobeh et al.   Antioxidants

The Mediterranean Diet and Cardiovascular Disease

(2018) Norman J Temple et al.   Cardiology in Review

Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma

(2018) Ferdinando Bruno et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Research on Dietary Polyphenols and Health: A Call of Caution and a Guide on How To Proceed

(2018) María Ángeles Ávila-Gálvez et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Leukotriene biosynthetic enzymes as therapeutic targets

(2018) Jesper Z. Haeggström   JOURNAL OF CLINICAL INVESTIGATION

Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2

(2018) Robert E. Boer et al.   ORGANIC LETTERS

Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15R-prostaglandins that inhibit platelet aggregation

(2018) Juan A. Giménez-Bastida et al.   FASEB JOURNAL

Cell Trafficking Interference in Inflammatory Bowel Disease: Therapeutic Interventions Based on Basic Pathogenesis Concepts

(2018) Tamara Pérez-Jeldres et al.   INFLAMMATORY BOWEL DISEASES

Frontline Science: Reprogramming COX-2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis

(2018) Yanzhuo Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGFβ-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues

(2018) Andrew G Kunihiro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Endothelial Cells Deconjugate Resveratrol Metabolites to Free Resveratrol: A Possible Role in Tissue Factor Modulation

(2018) Sara Fernández-Castillejo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

(2018) Nour Yahfoufi et al.   Nutrients

Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes

(2017) Juan A. Giménez-Bastida et al.   FASEB JOURNAL

In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

(2017) Puttaraju Srikantamurthy Yashaswini et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Biomimetic synthesis of hemiketal eicosanoids for biological testing

(2017) Juan A. Giménez-Bastida et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Non-extractable polyphenols produce gut microbiota metabolites that persist in circulation and show anti-inflammatory and free radical-scavenging effects

(2017) Antonio González-Sarrías et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Chronic Inflammatory Diseases and Green Tea Polyphenols

(2017) Helieh Oz   Nutrients

Mediterranean diet as a protection against asthma: Still another brick in building a causative association

(2016) L. Garcia-Marcos   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-κB signaling pathway

(2016) Shobha Bhaskar et al.   CELLULAR IMMUNOLOGY

Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis

(2016) Giovanni Pallio et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Plant sterol-enriched soy milk consumption modulates 5-lipoxygenase, 12-lipoxygenase, and myeloperoxidase activities in healthy adults – a randomized-controlled trial

(2016) Xing Lin Ho et al.   FREE RADICAL RESEARCH

Relative Inhibitions of 5-Lipoxygenase and Myeloperoxidase and Free-Radical Scavenging Activities of Daidzein, Dihydrodaidzein, and Equol

(2016) Shin Yih Tsen et al.   JOURNAL OF MEDICINAL FOOD

Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes

(2016) Cara L. Frankenfeld   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age

(2016) Xavier Capó et al.   Nutrients

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro

(2015) Xiayun Chang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory activity studies on the stems and roots of Jasminum lanceolarium Roxb

(2015) Wen-xia Yan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Oxylipins in the spikemoss Selaginella martensii: Detection of divinyl ethers, 12-oxophytodienoic acid and related cyclopentenones

(2015) Anna V. Ogorodnikova et al.   PHYTOCHEMISTRY

The role of lipoxygenases in pathophysiology; new insights and future perspectives

(2015) Ryuichi Mashima et al.   Redox Biology

Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

(2014) Xian Li et al.   Biomolecules & Therapeutics

Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis

(2014) F. C. Ringholz et al.   EUROPEAN RESPIRATORY JOURNAL

Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund׳s adjuvant induced arthritis in rats

(2014) Bing Lin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Transcellular biosynthesis of eicosanoids

(2014) Angelo Sala et al.   Pharmacological Reports

Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats

(2014) Cheng-Jian Zheng et al.   PHYTOMEDICINE

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

(2014) P. C. Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atropa acuminata Royle Ex Lindl. blunts production of pro-inflammatory mediators eicosanoids., leukotrienes, cytokines in vitro and in vivo models of acute inflammatory responses

(2013) Albeena Nisar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Mitochondrial Dysfunction Leads to Deconjugation of Quercetin Glucuronides in Inflammatory Macrophages

(2013) Akari Ishisaka et al.   PLoS One

Trihydroxyflavones with antioxidant and anti-inflammatory efficacy

(2012) Ana Gomes et al.   BIOFACTORS

Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis

(2012) R. J. Widmer et al.   EUROPEAN JOURNAL OF NUTRITION

Quercetin alleviates hypercholesterolemic diet induced inflammation during progression and regression of atherosclerosis in rabbits

(2012) Shobha Bhaskar et al.   NUTRITION

Glucuronidated Quercetin Lowers Blood Pressure in Spontaneously Hypertensive Rats via Deconjugation

(2012) Pilar Galindo et al.   PLoS One

Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents

(2011) Oh Song Kwon et al.   ARCHIVES OF PHARMACAL RESEARCH

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes

(2011) Noemi Tejera et al.   JOURNAL OF LIPID RESEARCH

Vascular deconjugation of quercetin glucuronide: The flavonoid paradox revealed?

(2011) Carmen Menendez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways

(2011) M. Griesser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human recombinant IL-1 receptor antagonist (IL-IRa) inhibits leukotriene B4 generation from human monocyte suspensions stimulated by lipopolysaccharide (LPS)

(2010) P. CONTI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglyconein vivo

(2010) Junji Terao et al.   Food & Function

A Citrus Extract Containing Flavanones Represses Plasminogen Activator Inhibitor-1 (PAI-1) Expression and Regulates Multiple Inflammatory, Tissue Repair, and Fibrosis Genes in Human Colon Fibroblasts

(2009) Juan A. Giménez-Bastida et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2

(2009) Surafel Mulugeta et al.   JOURNAL OF LIPID RESEARCH

Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice

(2009) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Time Course of Changes in the Expression of Insulin Sensitivity-Related Genes after an Acute Load of Virgin Olive Oil

(2009) Valentini Konstantinidou et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

(2009) S. Zarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5-Oxo-ETE and the OXE receptor

(2009) Gail E. Grant et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Characterization and modulation of canine mast cell derived eicosanoids

(2009) Tzu-Yin Lin et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport

(2008) Michael P. W. Moos et al.   FASEB JOURNAL

Macrophage as a Target of Quercetin Glucuronides in Human Atherosclerotic Arteries

(2008) Yoshichika Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst

(2008) V. Viji et al.   JOURNAL OF ETHNOPHARMACOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity

(2007) Wai Mun Loke et al.   BIOCHEMICAL PHARMACOLOGY