Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment
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Title
Design, synthesis, biological evaluation, and computational studies of novel thiazolo-pyrazole hybrids as promising selective COX-2 inhibitors: Implementation of apoptotic genes expression for ulcerogenic liability assessment
Authors
Keywords
COX-2, Thiazolo-pyrazole hybrids, Molecular modeling, Apoptosis, Gene expression, Ulcerogenic liability
Journal
BIOORGANIC CHEMISTRY
Volume 111, Issue -, Pages 104883
Publisher
Elsevier BV
Online
2021-04-01
DOI
10.1016/j.bioorg.2021.104883
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