NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

(2017) Sannula Kesavardhana et al.   INTERNATIONAL IMMUNOLOGY

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome

(2017) Ying‑Ming Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Atopic dermatitis

(2016) Stephan Weidinger et al.   LANCET

NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation

(2015) Delong Jiao et al.   Cellular & Molecular Immunology

The Genetics and Epigenetics of Atopic Dermatitis—Filaggrin and Other Polymorphisms

(2015) Yunsheng Liang et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans

(2015) Q. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Impaired NLRP3 inflammasome expression and function in atopic dermatitis due to Th2 milieu

(2014) M. Niebuhr et al.   ALLERGY

Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1

(2014) Yun-peng Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome

(2013) Wen Liu et al.   BIOCHEMICAL PHARMACOLOGY

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

(2013) Naoko Kamo et al.   HEPATOLOGY

Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation

(2013) Yue Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity

(2013) Kenji Kabashima   JOURNAL OF DERMATOLOGICAL SCIENCE

Genetic Variation in the Inflammasome and Atopic Dermatitis Susceptibility

(2013) Cecilia Bivik et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mild Asthma

(2013) Elisabeth H. Bel   NEW ENGLAND JOURNAL OF MEDICINE

Transfusion-Related Acute Lung Injury: The Work of DAMPs*

(2013) Walter G. Land   TRANSFUSION MEDICINE AND HEMOTHERAPY

The Role of the Inflammasome in Ventilator-induced Lung Injury

(2012) Claudia C. dos Santos   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

Caspase-1: is IL-1 just the tip of the ICEberg?

(2012) A Denes et al.   Cell Death & Disease

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant

(2011) A.-G. Besnard et al.   ALLERGY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Heme oxygenase-1 ameliorates LPS-induced acute lung injury correlated with downregulation of interleukin-33

(2011) Hui Yin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

(2011) Rebecca C. Coll et al.   PLoS One

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

Recent insights into atopic dermatitis and implications for management of infectious complications

(2010) Mark Boguniewicz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

(2009) R. Munoz-Planillo et al.   JOURNAL OF IMMUNOLOGY

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

(2009) S. B. Willingham et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Molecular regulation of inflammation and cell death

(2008) Garabet Yeretssian et al.   CYTOKINE

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY