ACT001 Ameliorates ionizing radiation-induced lung injury by inhibiting NLRP3 inflammasome pathway

ACT001 attenuates microglia-mediated neuroinflammation after traumatic brain injury via inhibiting AKT/NFκB/NLRP3 pathway

(2022) Lin Cai et al.   Cell Communication and Signaling

Predicting tumour radiosensitivity to deliver precision radiotherapy

(2022) James M. Price et al.   Nature Reviews Clinical Oncology

Acinar cell NLRP3 inflammasome and GSDMD activation mediates pyroptosis and systemic inflammation in acute pancreatitis

(2021) Lin Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biology of Radiation-Induced Lung Injury

(2021) Soumyajit Roy et al.   SEMINARS IN RADIATION ONCOLOGY

The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation

(2021) Chuanhui Han et al.   Science Immunology

Inhibition of NF-κB by ACT001 reduces fibroblast activity in idiopathic pulmonary fibrosis

(2021) Jade Jaffar et al.   BIOMEDICINE & PHARMACOTHERAPY

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Ameliorative effect of selective NLRP3 inflammasome inhibitor MCC950 in an ovalbumin-induced allergic rhinitis murine model

(2020) Weitian Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Glucosamine protects against radiation‐induced lung injury via inhibition of epithelial‐mesenchymal transition

(2020) Xiao Lei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification of Gene Expression Changes Associated With Uterine Receptivity in Mice

(2019) Jia-Peng He et al.   Frontiers in Physiology

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

p-Coumaric Acid Attenuates Lipopolysaccharide-Induced Lung Inflammation in Rats by Scavenging ROS Production: an In Vivo and In Vitro Study

(2019) Maryam Kheiry et al.   INFLAMMATION

The efficacy and safety of amifostine for the acute radiation syndrome

(2019) Vijay K. Singh et al.   Expert Opinion On Drug Safety

Lung tissue extracellular matrix‐derived hydrogels protect against radiation‐induced lung injury by suppressing epithelial–mesenchymal transition

(2019) Jing Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Radiation-Induced Lung Injury (RILI)

(2019) Lorena Giuranno et al.   Frontiers in Oncology

Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review

(2019) Danbin Wu et al.   INFLAMMATION

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

(2019) Jian Gao et al.   Cell Death & Disease

Pharmacokinetics, tissue distribution and excretion of ACT001 in Sprague-Dawley rats and metabolism of ACT001

(2018) Xiao-Nan Xi et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo

(2017) Katherine L. Morel et al.   RADIATION RESEARCH

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Integrated network analysis to explore the key genes regulated by parathyroid hormone receptor 1 in osteosarcoma

(2017) Donghui Guan et al.   World Journal of Surgical Oncology

NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages

(2017) Yan-gang Liu et al.   Cell Death & Disease

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

(2016) Bo Hu et al.   SCIENCE

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

The inflammasome accelerates radiation-induced lung inflammation and fibrosis in mice

(2015) Sung-Hwa Sohn et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

(2014) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Novel Synthetic SOD/Catalase Mimetics Can Mitigate Capillary Endothelial Cell Apoptosis Caused by Ionizing Radiation

(2010) Ekaterina Vorotnikova et al.   RADIATION RESEARCH

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY