NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Pyroptosis as a Regulated Form of Necrosis

(2016) Jun-ichi Abe et al.   CIRCULATION RESEARCH

N-acetyl tryptophan glucopyranoside (NATG) as a countermeasure against gamma radiation-induced immunosuppression in murine macrophage J774A.1 cells

(2016) Poonam Malhotra et al.   FREE RADICAL RESEARCH

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice

(2016) Lena Seifert et al.   GASTROENTEROLOGY

Polarization of macrophages towards M1 phenotype by a combination of 2-deoxy- d -glucose and radiation: Implications for tumor therapy

(2016) Abdullah Farooque et al.   IMMUNOBIOLOGY

Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome

(2016) Zi-Teng Zhang et al.   Journal of Neuroinflammation

Late Effects of Total-Body Gamma Irradiation on Cardiac Structure and Function in Male Rhesus Macaques

(2016) Ryne J. DeBo et al.   RADIATION RESEARCH

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

(2016) Haiyan Chen et al.   TOXICOLOGY LETTERS

Regulatory T Cells Contribute to the Inhibition of Radiation-Induced Acute Lung Inflammation via Bee Venom Phospholipase A2 in Mice

(2016) Dasom Shin et al.   Toxins

Radiation takes its Toll

(2015) Josephine A. Ratikan et al.   CANCER LETTERS

The inflammasome accelerates radiation-induced lung inflammation and fibrosis in mice

(2015) Sung-Hwa Sohn et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis

(2015) Yan Geng et al.   JOURNAL OF HEPATOLOGY

Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study

(2015) Jeffrey D Bradley et al.   LANCET ONCOLOGY

Hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate-risk localised prostate cancer: 2-year patient-reported outcomes of the randomised, non-inferiority, phase 3 CHHiP trial

(2015) Anna Wilkins et al.   LANCET ONCOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

X-ray irradiation accelerates senescence in hippocampal neural stem/progenitor cells via caspase-1 activation

(2015) Tao Li et al.   NEUROSCIENCE LETTERS

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells

(2014) Veit M. Stoecklein et al.   JOURNAL OF IMMUNOLOGY

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

(2014) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Radiotherapy for renal-cell carcinoma

(2014) Gert De Meerleer et al.   LANCET ONCOLOGY

A Pattern of Early Radiation-Induced Inflammatory Cytokine Expression Is Associated with Lung Toxicity in Patients with Non-Small Cell Lung Cancer

(2014) Shankar Siva et al.   PLoS One

Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

(2014) Wanwan Huai et al.   Nature Communications

A New Twist on Radiation Oncology: Low-Dose Irradiation Elicits Immunostimulatory Macrophages that Unlock Barriers to Tumor Immunotherapy

(2013) Michele De Palma et al.   CANCER CELL

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Pyroptotic death storms and cytopenia

(2013) Ben A Croker et al.   CURRENT OPINION IN IMMUNOLOGY

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Responses to ionizing radiation mediated by inflammatory mechanisms

(2013) Debayan Mukherjee et al.   JOURNAL OF PATHOLOGY

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Radiation-induced angiogenic signaling pathway in endothelial cells obtained from normal and cancer tissue of human breast

(2013) E-T Oh et al.   ONCOGENE

Burning Down the House: Cellular Actions during Pyroptosis

(2013) Christopher N. LaRock et al.   PLoS Pathogens

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

New insights into the molecular pathology of radiation-induced pneumopathy

(2011) Federica Cappuccini et al.   RADIOTHERAPY AND ONCOLOGY

Role of the Nlrp3 Inflammasome in Microbial Infection

(2011) Paras K. Anand et al.   Frontiers in Microbiology

Regulation of adaptive immunity by the NLRP3 inflammasome

(2010) Mingkuan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

(2010) G.-O. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extremely low frequency electromagnetic field enhances human keratinocyte cell growth and decreases proinflammatory chemokine production

(2008) G. Vianale et al.   BRITISH JOURNAL OF DERMATOLOGY