Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity

Isoliquiritigenin alleviates diabetic symptoms via activating AMPK and inhibiting mTORC1 signaling in diet-induced diabetic mice

(2022) Lin Yang et al.   PHYTOMEDICINE

The protective effect of isoliquiritigenin against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling as one key mechanism

(2022) Wahidah H. Al-Qahtani et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

Resveratrol significantly improves cell survival in comparison to dexrazoxane and carvedilol in a h9c2 model of doxorubicin induced cardiotoxicity

(2021) David S. Monahan et al.   BIOMEDICINE & PHARMACOTHERAPY

A Systematic Review of the Potential Chemoprotective Effects of Resveratrol on Doxorubicin-Induced Cardiotoxicity: Focus on the Antioxidant, Antiapoptotic, and Anti-Inflammatory Activities

(2021) Li-Feng Hu et al.   Oxidative Medicine and Cellular Longevity

Isoliquiritigenin prevents Doxorubicin-induced hepatic damage in rats by upregulating and activating SIRT1

(2021) Wahidah H. Al-Qahtani et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes

(2021) Rebecca L. Swan et al.   MOLECULAR PHARMACOLOGY

Development and evaluation of a gp85 protein-based subgroup-specific indirect enzyme-linked immunosorbent assay for the detection of anti-subgroup J avian leukosis virus antibodies

(2020) Fangfang Chang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

FocAn: automated 3D analysis of DNA repair foci in image stacks acquired by confocal fluorescence microscopy

(2020) Simon Memmel et al.   BMC BIOINFORMATICS

Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity

(2020) Can Hu et al.   Clinical and Translational Medicine

Deep-Learning-Assisted Assessment of DNA Damage Based on Foci Images and Its Application in High-Content Screening of Lead Compounds

(2020) Xuechun Chen et al.   ANALYTICAL CHEMISTRY

Preventing and Treating Anthracycline Cardiotoxicity: New Insights

(2020) Konrad Teodor Sawicki et al.   Annual Review of Pharmacology and Toxicology

Humanin Analogue (HNG) Enhances the Protective Effect of Dexrazoxane against Doxorubicin-induced Cardiotoxicity

(2018) YanHe Lue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

53BP1: A key player of DNA damage response with critical functions in cancer

(2018) Mohammad Mirza-Aghazadeh-Attari et al.   DNA REPAIR

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Cardioprotection and Second Malignant Neoplasms Associated With Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis

(2015) Furqan Shaikh et al.   JNCI-Journal of the National Cancer Institute

A Review: The Pharmacology of Isoliquiritigenin

(2015) Fu Peng et al.   PHYTOTHERAPY RESEARCH

Cardioprotection and Second Malignant Neoplasms Associated With Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis

(2015) Furqan Shaikh et al.   JNCI-Journal of the National Cancer Institute

OpenComet: An automated tool for comet assay image analysis

(2014) Benjamin M. Gyori et al.   Redox Biology

Topoisomerase 2β: A Promising Molecular Target for Primary Prevention of Anthracycline-Induced Cardiotoxicity

(2013) P Vejpongsa et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Protection against peroxynitrite-induced DNA damage by mesalamine: implications for anti-inflammation and anti-cancer activity

(2013) Paul M. Graham et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Low to Moderate Dose Anthracycline-Based Chemotherapy Is Associated With Early Noninvasive Imaging Evidence of Subclinical Cardiovascular Disease

(2013) Brandon C. Drafts et al.   JACC-Cardiovascular Imaging

Rac1 Protein Signaling Is Required for DNA Damage Response Stimulated by Topoisomerase II Poisons

(2012) Stefanie C. Huelsenbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Pharmacokinetic evaluation of doxorubicin plasma levels in normal and overweight patients with breast cancer and simulation of dose adjustment by different indexes of body mass

(2010) Deise Raquel Barpe et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Stabilization of mitochondrial membrane potential prevents doxorubicin-induced cardiotoxicity in isolated rat heart

(2010) David Montaigne et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

(2009) Partha Mukhopadhyay et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition

(2009) Iha Park et al.   CANCER LETTERS

Cardiovascular Complications of Cancer Therapy

(2009) Edward T.H. Yeh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Topoisomerase II -dependent and -independent apoptotic effects of dexrazoxane and doxorubicin

(2009) T. Yan et al.   MOLECULAR CANCER THERAPEUTICS