WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells

WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein

(2023) Jianping Zou et al.   Cell Communication and Signaling

Activation of E3 ubiquitin ligase WWP2 by non‐receptor tyrosine kinase ACK1

(2023) Jun Zhu et al.   IUBMB LIFE

lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1

(2023) Zhen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma

(2022) Yong Qin et al.   CELL BIOLOGY INTERNATIONAL

The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia

(2022) Xinxin Lu et al.   Cell Death Discovery

Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling

(2021) Luam E. Araya et al.   ACS Chemical Biology

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

(2021) Kevin D. Freeman-Cook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclin E in normal physiology and disease states

(2021) Chen Chu et al.   TRENDS IN CELL BIOLOGY

Etomidate inhibits cell proliferation and induces apoptosis in A549 non‑small cell lung cancer cells via downregulating WWP2

(2021) Deqiang Li et al.   Experimental and Therapeutic Medicine

Apoptosis regulation at the mitochondria membrane level

(2021) Shashank Dadsena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability

(2021) Rafaela Fagundes et al.   Frontiers in Cell and Developmental Biology

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation

(2020) Hong Che et al.   CELL BIOCHEMISTRY AND FUNCTION

Targeting apoptotic caspases in cancer

(2020) Ashley Boice et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Long noncoding RNA Linc02023 regulates PTEN stability and suppresses tumorigenesis of colorectal cancer in a PTEN-dependent pathway

(2019) Qingyuan Wang et al.   CANCER LETTERS

ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis

(2019) Lei Wang et al.   CARCINOGENESIS

miR-301a Regulates Inflammatory Response to Japanese Encephalitis Virus Infection via Suppression of NKRF Activity

(2019) Bibhabasu Hazra et al.   JOURNAL OF IMMUNOLOGY

WWP2 regulates proliferation of gastric cancer cells in a PTEN-dependent manner

(2019) Ke Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myeloid cell–targeted miR-146a mimic inhibits NF-κB–driven inflammation and leukemia progression in vivo

(2019) Yu-Lin Su et al.   BLOOD

Isoliquiritigenin Inhibits IL-1β-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes

(2018) Lei Zhang et al.   Molecular Therapy-Methods & Clinical Development

Puerarin attenuates neurological deficits via Bcl-2/Bax/cleaved caspase-3 and Sirt3/SOD2 apoptotic pathways in subarachnoid hemorrhage mice

(2018) Yu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

WWP2 Is One Promising Novel Oncogene

(2018) Rui Zhang et al.   PATHOLOGY & ONCOLOGY RESEARCH

The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation

(2017) Wei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New drugs in acute myeloid leukemia: Table 1.

(2016) T. M. Kadia et al.   ANNALS OF ONCOLOGY

Elevated expression of WWP2 in human lung adenocarcinoma and its effect on migration and invasion

(2016) Rui Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Constitutive NF-κB activation in AML: Causes and treatment strategies

(2016) Matthieu Cornelis Johannes Bosman et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Cyclin D1 and cyclin E2 are differentially expressed in gastric cancer

(2016) Soni Kumari et al.   MEDICAL ONCOLOGY

Inhibition of WWP2 suppresses proliferation, and induces G1 cell cycle arrest and apoptosis in liver cancer cells

(2016) SHENG-QIAN XU et al.   Molecular Medicine Reports

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

‘Acute myeloid leukemia: a comprehensive review and 2016 update’

(2016) I De Kouchkovsky et al.   Blood Cancer Journal

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

(2015) Lydia WT Cheung et al.   eLife

NF-κB pathways in hematological malignancies

(2014) Chiara Gasparini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian Cancer

(2014) Jin-Gyoung Jung et al.   PLoS Genetics

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

(2013) Matthew Brentnall et al.   BMC CELL BIOLOGY

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

miR-301a as an NF-κB activator in pancreatic cancer cells

(2010) Zhongxin Lu et al.   EMBO JOURNAL

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

(2010) Weiguo Zou et al.   NATURE CELL BIOLOGY

Nuclear factor-κB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia

(2008) Christopher Jenkins et al.   BRITISH JOURNAL OF HAEMATOLOGY