Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability

Targeting cell-cycle machinery in cancer

(2021) Jan M. Suski et al.   CANCER CELL

Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication

(2021) Manzar Hossain et al.   MOLECULAR CELL

Cell cycle control in cancer

(2021) Helen K. Matthews et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyclin E in normal physiology and disease states

(2021) Chen Chu et al.   TRENDS IN CELL BIOLOGY

Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover

(2020) Laura L. Thompson et al.   Cancers

A novel landscape of nuclear human CDK2 substrates revealed by in situ phosphorylation

(2020) Yong Chi et al.   Science Advances

Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer

(2020) Christine Lee et al.   Cancers

Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases

(2020) Roberto Bellelli et al.   TRENDS IN GENETICS

Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

(2020) Yannick P. Kok et al.   Oncogenesis

Targeting CDK2 in cancer: challenges and opportunities for therapy

(2019) Solomon Tadesse et al.   DRUG DISCOVERY TODAY

The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

(2018) Francesca Menghi et al.   CANCER CELL

Low-Molecular-Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies

(2018) Joseph A. Caruso et al.   CANCER RESEARCH

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

(2018) Morgane Macheret et al.   NATURE

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

(2017) Huiming Lu et al.   Nature Communications

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo

(2016) Junko Odajima et al.   PLoS Genetics

Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription

(2016) Manzar Hossain et al.   eLife

Cyclin E Deregulation Promotes Loss of Specific Genomic Regions

(2015) Leonardo K. Teixeira et al.   CURRENT BIOLOGY

Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation

(2015) Courtney G. Sansam et al.   GENES & DEVELOPMENT

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of mammalian nucleotide metabolism and biosynthesis

(2015) Andrew N. Lane et al.   NUCLEIC ACIDS RESEARCH

Oncogenes create a unique landscape of fragile sites

(2015) Karin Miron et al.   Nature Communications

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Transcription-replication encounters, consequences and genomic instability

(2013) Anne Helmrich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation

(2013) B. T. Hughes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

Helicase Activation and Establishment of Replication Forks at Chromosomal Origins of Replication

(2013) S. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

An integrated view of cyclin E function and regulation

(2012) Ka Tat Siu et al.   CELL CYCLE

Loss of Cyclin-Dependent Kinase 2 (CDK2) Inhibitory Phosphorylation in a CDK2AF Knock-In Mouse Causes Misregulation of DNA Replication and Centrosome Duplication

(2012) H. Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

(2012) R M Jones et al.   ONCOGENE

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans

(2011) Dominik Boos et al.   CURRENT BIOLOGY

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

(2011) Akiko Kumagai et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomics Reveals the Basis for the Biochemical Specificity of the Cell-Cycle Machinery

(2011) Felicia Walton Pagliuca et al.   MOLECULAR CELL

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

(2011) Matilde Murga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

(2011) Bart Westendorp et al.   NUCLEIC ACIDS RESEARCH

Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins

(2011) V. Liberal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic Chromosome DNA Replication: Where, When, and How?

(2010) Hisao Masai et al.   Annual Review of Biochemistry

Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication

(2010) Akiko Kumagai et al.   CELL

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer

(2010) C Caldon et al.   Cell Division

Phosphorylation of Mcm2 by Cdc7 Promotes Pre-replication Complex Assembly during Cell-Cycle Re-entry

(2009) Li-Chiou Chuang et al.   MOLECULAR CELL