The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia

The Downregulation of Both Giant HERCs, HERC1 and HERC2, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation

(2022) Muhammad Shahzad Ali et al.   Journal of Clinical Medicine

Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis

(2022) Qian Chen et al.   Cell Discovery

PARP1 Upregulation in Recurrent Oral Cancer and Treatment Resistance

(2022) Feifei Wang et al.   Frontiers in Cell and Developmental Biology

PaDef (Persea americana var. drymifolia), a Plant Antimicrobial Peptide, Triggers Apoptosis, and Induces Global Epigenetic Modifications on Histone 3 in an Acute Lymphoid Leukemia Cell Line

(2022) Paola Jiménez-Alcántar et al.   Frontiers in Molecular Biosciences

The expanding universe of PARP1-mediated molecular and therapeutic mechanisms

(2022) Dan Huang et al.   MOLECULAR CELL

HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer

(2022) Hanlin Ma et al.   Cell Death & Disease

A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression

(2022) Malka Cohen-Armon   Cells

Ubiquitination in the regulation of inflammatory cell death and cancer

(2021) Peter E. Cockram et al.   CELL DEATH AND DIFFERENTIATION

The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner

(2021) Muhammad Shahzad Ali et al.   Cancers

CircTLK1 modulates sepsis‐induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis–mediated mitochondrial DNA damage by sponging miR‐17‐5p

(2021) Yu Qiu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PARP1-modulated chromatin remodeling is a new target for cancer treatment

(2021) Saptarshi Sinha et al.   MEDICAL ONCOLOGY

Etomidate inhibits cell proliferation and induces apoptosis in A549 non‑small cell lung cancer cells via downregulating WWP2

(2021) Deqiang Li et al.   Experimental and Therapeutic Medicine

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

(2021) Ali Khateb et al.   Nature Communications

Novel Markers in Pediatric Acute Lymphoid Leukemia: The Role of ADAM6 in B Cell Leukemia

(2021) Laila Alsuwaidi et al.   Frontiers in Cell and Developmental Biology

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

(2021) Karthik Selvaraju et al.   Biomolecules

Poly (ADP-ribose) polymerase-1 (PARP1) as a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.

(2021) Christina-Nefeli Kontandreopoulou et al.   Blood Advances

TPGS2000-DOX Prodrug Micelles for Improving Breast Cancer Therapy

(2021) Lan Tang et al.   International Journal of Nanomedicine

PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers

(2021) Anna J. Dellomo et al.   Translational Oncology

Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition

(2021) Giuseppina Raspaglio et al.   Cell Death & Disease

Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia

(2021) Limei Wu et al.   Nature Communications

Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury

(2021) Naijin Zhang et al.   Redox Biology

Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling

(2020) Naijin Zhang et al.   CELL DEATH AND DIFFERENTIATION

Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury

(2020) Naijin Zhang et al.   Redox Biology

Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells

(2020) Paulina Gil-Kulik et al.   BMC CANCER

The E3 ubiquitin ligase Smurf2 regulates PARP1 stability to alleviate oxidative stress‐induced injury in human umbilical vein endothelial cells

(2020) Hao Qian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells – involvement of carbonyl reductase 1

(2020) Paulina Koczurkiewicz-Adamczyk et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The multifaceted role of PARP1 in RNA biogenesis

(2020) Rebekah Eleazer et al.   Wiley Interdisciplinary Reviews-RNA

RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance

(2019) Wenzhe Yan et al.   Cancer Cell International

Cul4a as a New Interaction Protein of PARP1 Inhibits Oxidative Stress-Induced H9c2 Cell Apoptosis

(2019) Ning Ye et al.   Oxidative Medicine and Cellular Longevity

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

(2019) Sho Mokuda et al.   Nature Communications

ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis

(2019) Lei Wang et al.   CARCINOGENESIS

WWP2 regulates proliferation of gastric cancer cells in a PTEN-dependent manner

(2019) Ke Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CPSF7 regulates liver cancer growth and metastasis by facilitating WWP2-FL and targeting the WWP2/PTEN/AKT signaling pathway

(2019) Shiji Fang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia

(2018) Hao Wang et al.   ONCOGENE

WWP2 Is One Promising Novel Oncogene

(2018) Rui Zhang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Introduction to a review series: the 2016 revision of the WHO classification of tumors of hematopoietic and lymphoid tissues

(2016) M. Cazzola   BLOOD

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid

(2016) Rui Shao et al.   CELL RESEARCH

E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia

(2016) I-K Park et al.   LEUKEMIA

Inhibition of WWP2 suppresses proliferation, and induces G1 cell cycle arrest and apoptosis in liver cancer cells

(2016) SHENG-QIAN XU et al.   Molecular Medicine Reports

NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

(2015) Pranay Goel et al.   GENE

E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin-proteasome pathway plays essential roles in ATRA-induced leukemia cells G0/G1phase arrest and transition into granulocytic differentiation

(2011) Yanfen Fang et al.   CANCER BIOLOGY & THERAPY

Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells

(2011) B Casar et al.   ONCOGENE

WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells

(2009) Huiming Xu et al.   CELL RESEARCH

Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

(2008) R. Krishnakumar et al.   SCIENCE