Anemonin ameliorates Human Diploid Fibroblasts 2BS and IMR90 cell senescence by PARP1-NAD+-SIRT1 signaling pathway

Anemonin reduces hydrogen peroxide-induced oxidative stress, inflammation and extracellular matrix degradation in nucleus pulposus cells by regulating NOX4/NF-κB signaling pathway

(2023) Zhijia Ma et al.   Journal of Orthopaedic Surgery and Research

Anemonin inhibits sepsis‐induced acute kidney injury via mitigating inflammation and oxidative stress

(2023) Dan Liu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Targeting aging mechanisms: pharmacological perspectives

(2022) Alexey Moskalev et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ

(2022) Lu Jiang et al.   Chinese Medicine

The role of PARP1 in neurodegenerative diseases and aging

(2021) Kanmin Mao et al.   FEBS Journal

Evolving concepts in NAD+ metabolism

(2021) Claudia C.S. Chini et al.   Cell Metabolism

Anemonin Attenuates RANKL-Induced Osteoclastogenesis and Ameliorates LPS-Induced Inflammatory Bone Loss in Mice via Modulation of NFATc1

(2020) Huanhuan Hou et al.   Frontiers in Pharmacology

The taming of PARP1 and its impact on NAD+ metabolism

(2020) Sarah Hurtado-Bagès et al.   Molecular Metabolism

Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation

(2020) Vivek Singh et al.   INFLAMMATION

SIRT1 and aging related signaling pathways

(2020) Cui Chen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Poly(ADP-ribose) polymerase inhibition: past, present and future

(2020) Nicola J. Curtin et al.   NATURE REVIEWS DRUG DISCOVERY

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

A decade of clinical development of PARP inhibitors in perspective

(2019) J Mateo et al.   ANNALS OF ONCOLOGY

The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers

(2019) Tatiana Kamaletdinova et al.   Cells

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

(2018) Agnes L.C. Ong et al.   AGEING RESEARCH REVIEWS

Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders

(2018) Robert J. Henning et al.   Cardiovascular Toxicology

Anti-Aging Drugs – Prospect of Longer Life?

(2018) Blanka Klimova et al.   CURRENT MEDICINAL CHEMISTRY

PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

(2018) Siyuan Zha et al.   Stem Cell Research & Therapy

PARPs in genome stability and signal transduction: implications for cancer therapy

(2018) Luca Palazzo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway

(2017) Zuqiang Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review

(2017) Vamshi K.C. Nimmagadda et al.   JOURNAL OF NEUROIMMUNOLOGY

Antifungal, molluscicidal and larvicidal assessment of anemonin and Clematis flammula L. extracts against mollusc Galba truncatula , intermediate host of Fasciola hepatica in Tunisia

(2017) Rakia Saidi et al.   Asian Pacific Journal of Tropical Medicine

Anemonin Alleviates Nerve Injury After Cerebral Ischemia and Reperfusion (I/R) in Rats by Improving Antioxidant Activities and Inhibiting Apoptosis Pathway

(2014) Dong Jia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1

(2010) Aswin Mangerich et al.   MECHANISMS OF AGEING AND DEVELOPMENT

PARP1 ADP-ribosylates lysine residues of the core histone tails

(2010) Simon Messner et al.   NUCLEIC ACIDS RESEARCH

Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function

(2009) Simon Messner et al.   FASEB JOURNAL

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL