PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

(2018) Agnes L.C. Ong et al.   AGEING RESEARCH REVIEWS

NAD+ Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging: Mechanisms and Therapeutic Implications

(2018) Mingchao Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

SA1/SA2 cohesion proteins and SIRT1-NAD+ deacetylase modulate telomere homeostasis in cumulus cells and are eligible biomarkers of ovarian aging

(2018) D Valerio et al.   HUMAN REPRODUCTION

SIRT1 inhibits TGF-β-induced endothelial-mesenchymal transition in human endothelial cells with Smad4 deacetylation

(2018) Zhen Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice

(2018) Shishun Huang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent

(2018) Steven T. Sizemore et al.   MOLECULAR CANCER RESEARCH

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soft tissue sarcomas: new opportunity of treatment with PARP inhibitors?

(2018) Monica Mangoni et al.   Radiologia Medica

Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress–Induced Aging in Chorion Cells

(2018) Liping Feng et al.   Reproductive Sciences

MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells

(2018) Chunli Wang et al.   Stem Cell Research & Therapy

A need for NAD+ in muscle development, homeostasis, and aging

(2018) Michelle F. Goody et al.   Skeletal Muscle

Melatonin reverses H2 O2 -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB

(2017) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress

(2017) Gireedhar Venkatachalam et al.   NUCLEIC ACIDS RESEARCH

The Aging Risk and Atherosclerosis: A Fresh Look at Arterial Homeostasis

(2017) Trajen Head et al.   Frontiers in Genetics

Weight Loss Is Associated With Increased NAD+/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue

(2016) Elisabeth Rappou et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Endothelial progenitor cells (EPCs) in ageing and age-related diseases: How currently available treatment modalities affect EPC biology, atherosclerosis, and cardiovascular outcomes

(2016) Velimir Altabas et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes

(2016) Lina Li et al.   Cell and Bioscience

Atherosclerosis

(2015) Hong Lu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Migrational changes of mesenchymal stem cells in response to cytokines, growth factors, hypoxia, and aging

(2015) Yahaira Naaldijk et al.   EXPERIMENTAL CELL RESEARCH

Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress

(2015) H Yang et al.   Cell Death & Disease

Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

(2015) Sonja Hänzelmann et al.   Clinical Epigenetics

Effects of Olmesartan on Endothelial Progenitor Cell Mobilization and Function in Carotid Atherosclerosis

(2015) Yong Zou   MEDICAL SCIENCE MONITOR

Poly(ADP-Ribose) Polymerase-1 Causes Mitochondrial Damage and Neuron Death Mediated by Bnip3

(2014) P. Lu et al.   JOURNAL OF NEUROSCIENCE

Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer

(2014) Kotaro Kiga et al.   RNA Biology

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast

(2013) Bari J. Ballew et al.   AGING CELL

A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta

(2013) Anna Bielak-Zmijewska et al.   BIOGERONTOLOGY

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

The effect of aging on migration, proliferation, and collagen expression of tenocytes in response to ciprofloxacin

(2011) Hsiang-Ning Chang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Treatment of Atherosclerosis by Transplantation of Bone Endothelial Progenitor Cells Over-Expressed Paraoxonase-1 Gene by Recombinant Adeno-Associated Virus in Rat

(2010) Feng Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN