The Placenta: A Maternofetal Interface

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

(2023) Katherine M. Kennedy et al.   NATURE

Morphological and functional changes in placentas from prolonged pregnancies

(2022) Amber Carroll et al.   PLACENTA

Emerging in vitro platforms and omics technologies for studying the endometrium and early embryo-maternal interface in humans

(2022) Mina Popovic et al.   PLACENTA

Placental genomics mediates genetic associations with complex health traits and disease

(2022) Arjun Bhattacharya et al.   Nature Communications

Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters

(2022) Rona Karahoda et al.   Frontiers in Cell and Developmental Biology

Dynamic genome-wide gene expression and immune cell composition in the developing human placenta

(2022) Hemant Suryawanshi et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Associations between maternal iron supplementation in pregnancy and offspring growth and cardiometabolic risk outcomes in infancy and childhood

(2022) Clive J. Petry et al.   PLoS One

Human placental development and function

(2022) Tereza Cindrova-Davies et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Placental multi-omics integration identifies candidate functional genes for birthweight

(2022) Fasil Tekola-Ayele et al.   Nature Communications

Fetomaternal Expression of Glucose Transporters (GLUTs)—Biochemical, Cellular and Clinical Aspects

(2022) Rafal Sibiak et al.   Nutrients

Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetric disease

(2022) Raymond W. Redline et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Materno-fetal iron transfer and the emerging role of ferroptosis pathways

(2022) Jonas Zaugg et al.   BIOCHEMICAL PHARMACOLOGY

Early human trophoblast development: from morphology to function

(2022) Martin Gauster et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Early steps of embryo implantation are regulated by exchange of extracellular vesicles between the embryo and the endometrium

(2022) Joanna Szuszkiewicz et al.   FASEB JOURNAL

Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism

(2022) Yiqin Wang et al.   Nature Communications

Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal–fetal interface

(2022) Quanlei Wang et al.   Scientific Reports

Gestational Diabetes Mellitus and Energy-Dense Diet: What Is the Role of the Insulin/IGF Axis?

(2022) Irene Martín-Estal et al.   Frontiers in Endocrinology

Primary specification of blastocyst trophectoderm by scRNA-seq: New insights into embryo implantation

(2022) Dandan Liu et al.   Science Advances

Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation

(2022) Irving L. M. H. Aye et al.   Communications Biology

Oxidative stress, lipid peroxidation and premature placental senescence in preeclampsia

(2022) Anne Negre-Salvayre et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The incidence, complications, and treatment of iron deficiency in pregnancy

(2022) Ashley E. Benson et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Trophoblast-Derived Extracellular Vesicles Promote Preeclampsia by Regulating Macrophage Polarization

(2022) Xiu Liu et al.   HYPERTENSION

Association between the ratio of placental weight to birthweight and the risk of neurodevelopmental delay in 3-year-Olds: The Japan environment and Children's study

(2022) Naomi Mitsuda et al.   PLACENTA

Uteroplacental versus fetal use of glucose in healthy pregnancies at term. A human in vivo study

(2022) Tore Henriksen et al.   PLACENTA

Extracellular vesicles secreted by human uterine stromal cells regulate decidualization, angiogenesis, and trophoblast differentiation

(2022) Qiuyan Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

(2022) Darcy T. Ahern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex at the interface: the origin and impact of sex differences in the developing human placenta

(2022) Amy E. Braun et al.   Biology of Sex Differences

Cell-specific characterization of the placental methylome

(2021) Victor Yuan et al.   BMC GENOMICS

Placental mobilization of free fatty acids contributes to altered materno-fetal transfer in obesity

(2021) Birgit Hirschmugl et al.   INTERNATIONAL JOURNAL OF OBESITY

Inherent mosaicism and extensive mutation of human placentas

(2021) Tim H. H. Coorens et al.   NATURE

Placental genomic risk scores and early neurodevelopmental outcomes

(2021) Gianluca Ursini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy

(2021) Peng Xu et al.   Frontiers in Cell and Developmental Biology

Is the erythropoietin-erythroferrone-hepcidin axis intact in human neonates?

(2021) Timothy M. Bahr et al.   BLOOD CELLS MOLECULES AND DISEASES

Impact of maternal iron deficiency anaemia on the expression of the newly discovered multi-copper ferroxidase, Zyklopen, in term placentas

(2021) M. V. Surekha et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

The RNA landscape of the human placenta in health and disease

(2021) Sungsam Gong et al.   Nature Communications

Transcriptomic Profiling of Human Placenta in Gestational Diabetes Mellitus at the Single-Cell Level

(2021) Yuqi Yang et al.   Frontiers in Endocrinology

Prenatal alcohol-related alterations in maternal, placental, neonatal, and infant iron homeostasis

(2021) R Colin Carter et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetic and in utero environmental contributions to DNA methylation variation in placenta

(2021) Suvo Chatterjee et al.   HUMAN MOLECULAR GENETICS

Prepregnancy Obesity Does Not Impact Placental Iron Trafficking

(2021) Lisa Tussing-Humphreys et al.   JOURNAL OF NUTRITION

Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples

(2021) Katherine M Delaney et al.   JOURNAL OF NUTRITION

Large-scale transcriptome-wide profiling of microRNAs in human placenta and maternal plasma at early to mid gestation

(2021) Melanie D. Smith et al.   RNA Biology

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first–second trimester transition

(2021) Malwina Prater et al.   Biology Open

From stem cells to spiral arteries: A journey through early placental development

(2021) Joanna L. James et al.   PLACENTA

Maternal, fetal and placental regulation of placental iron trafficking

(2021) Kimberly O. O'Brien   PLACENTA

Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy: Lessons from animal models

(2020) Amanda N. Sferruzzi-Perri et al.   PLACENTA

Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother–offspring birth cohort study

(2020) Mya-Thway Tint et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fetal adiposity epidemic in the modern world: a thrifty phenotype aggravated by maternal obesity and diabetes

(2020) Chittaranjan S Yajnik et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Maternal dietary fatty acids and their roles in human placental development

(2020) Asim K. Duttaroy et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Tracking placental development in health and disease

(2020) John D. Aplin et al.   Nature Reviews Endocrinology

Placental glycogen stores and fetal growth: insights from genetic mouse models

(2020) Simon J Tunster et al.   REPRODUCTION

Hypertensive Disorders of Pregnancy and Future Cardiovascular Health

(2020) Karen Melchiorre et al.   Frontiers in Cardiovascular Medicine

Associations between maternal lifetime stress and placental mitochondrial DNA mutations in an urban multi-ethnic cohort

(2020) Kelly J. Brunst et al.   BIOLOGICAL PSYCHIATRY

The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero†

(2020) Lindsey N Block et al.   BIOLOGY OF REPRODUCTION

Placental mitochondrial function in response to gestational exposures

(2020) Minhui Lu et al.   PLACENTA

Altered materno-fetal transfer of 13C-polyunsaturated fatty acids in obese pregnant women

(2019) A. Gázquez et al.   CLINICAL NUTRITION

Insulin stimulates GLUT4 trafficking to the syncytiotrophoblast basal plasma membrane in the human placenta

(2019) Laura B James-Allan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Maternal anemia and pregnancy outcomes: a population-based study

(2019) Rachael H. Beckert et al.   Journal of Perinatology

In vivo kinetic study of materno‐fetal fatty acid transfer in obese and normal weight pregnant women

(2019) Antonio Gázquez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

(2019) Hanlin Zhang et al.   MOLECULAR CELL

Effects of maternal iron status on placental and fetal iron homeostasis

(2019) Veena Sangkhae et al.   JOURNAL OF CLINICAL INVESTIGATION

A developmental landscape of 3D-cultured human pre-gastrulation embryos

(2019) Lifeng Xiang et al.   NATURE

A systems perspective on placental amino acid transport

(2018) Jane K. Cleal et al.   JOURNAL OF PHYSIOLOGY-LONDON

Convergence of placenta biology and genetic risk for schizophrenia

(2018) Gianluca Ursini et al.   NATURE MEDICINE

Evidence of oxidative stress-induced senescence in mature, post-mature and pathological human placentas

(2018) Tereza Cindrova-Davies et al.   PLACENTA

Development of the Human Placenta and Fetal Heart: Synergic or Independent?

(2018) Graham J. Burton et al.   Frontiers in Physiology

Blood Flow and Transport in the Human Placenta

(2018) Oliver E. Jensen et al.   Annual Review of Fluid Mechanics

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta 

(2018) Yawei Liu et al.   CELL RESEARCH

Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus

(2018) Sian Simpson et al.   CURRENT OPINION IN PHARMACOLOGY

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

A single-cell survey of the human first-trimester placenta and decidua

(2018) Hemant Suryawanshi et al.   Science Advances

Effect of Maternal Obesity on Placental Lipid Metabolism

(2017) Virtu Calabuig-Navarro et al.   ENDOCRINOLOGY

Elemental content of the placenta: A comparison between two high-risk obstetrical populations, adult women carrying multiples and adolescents carrying singletons

(2017) Paolo de Angelis et al.   ENVIRONMENTAL RESEARCH

Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface

(2017) Mihaela Pavličev et al.   GENOME RESEARCH

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

Feeding Your Baby In Utero: How the Uteroplacental Circulation Impacts Pregnancy

(2017) Joanna L. James et al.   PHYSIOLOGY

Review: Alterations in placental glycogen deposition in complicated pregnancies: Current preclinical and clinical evidence

(2017) Lisa K. Akison et al.   PLACENTA

Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis

(2017) Shaoning Jiang et al.   PLACENTA

Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics

(2017) Jason C. H. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenylalanine transfer across the isolated perfused human placenta: an experimental and modeling investigation

(2016) E. M. Lofthouse et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Maternal iron status during pregnancy compared with neonatal iron status better predicts placental iron transporter expression in humans

(2016) Cora M. Best et al.   FASEB JOURNAL

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Placental Nutrient Transport and Intrauterine Growth Restriction

(2016) Francesca Gaccioli et al.   Frontiers in Physiology

The ins and outs of maternal-fetal fatty acid metabolism

(2015) Rafał Bobiński et al.   ACTA BIOCHIMICA POLONICA

Fetal Sex and Maternal Risk of Gestational Diabetes Mellitus: The Impact of Having a Boy

(2015) Ravi Retnakaran et al.   DIABETES CARE

Sex of the baby and risk of gestational diabetes mellitus in the mother: a systematic review and meta-analysis

(2015) Diana Jaskolka et al.   DIABETOLOGIA

Pregnancy and Long-Term Maternal Cardiovascular Health

(2015) Anne Cathrine Staff et al.   HYPERTENSION

Practice Bulletin No. 150

(2015)   OBSTETRICS AND GYNECOLOGY

Placental expression of imprinted genes varies with sampling site and mode of delivery

(2015) A.B. Janssen et al.   PLACENTA

Tracking nutrient transfer at the human maternofetal interface from 4 weeks to term

(2015) C.J.P. Jones et al.   PLACENTA

Placental Fatty Acid Transfer: A Key Factor in Fetal Growth

(2014) Elvira Larqué et al.   ANNALS OF NUTRITION AND METABOLISM

Maternal Factors Associated with Fetal Growth and Birthweight Are Independent Determinants of Placental Weight and Exhibit Differential Effects by Fetal Sex

(2014) Marie Cecilie Paasche Roland et al.   PLoS One

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy

(2013) Carla Giordano et al.   BRAIN

Developmental origins of chronic disease

(2012) D.J.P. Barker   PUBLIC HEALTH

Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management

(2011) Francesc Figueras et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors

(2011) Boris Novakovic et al.   BMC GENOMICS

Placental Expression of the Heme Transporter, Feline Leukemia Virus Subgroup C Receptor, Is related to Maternal Iron Status in Pregnant Adolescents

(2011) Lindsay M. Jaacks et al.   JOURNAL OF NUTRITION

Maternal Hepcidin Is Associated with Placental Transfer of Iron Derived from Dietary Heme and Nonheme Sources

(2011) Melissa F. Young et al.   JOURNAL OF NUTRITION

Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast

(2011) J. K. Cleal et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation

(2011) K. Brown et al.   PLACENTA

Review: Oxygen and trophoblast biology – A source of controversy

(2011) M.G. Tuuli et al.   PLACENTA

Mechanisms involved in the selective transfer of long chain polyunsaturated fatty acids to the fetus

(2011) Alfonso Gil-Sánchez   Frontiers in Genetics

Identification of Zyklopen, a New Member of the Vertebrate Multicopper Ferroxidase Family, and Characterization in Rodents and Human Cells

(2010) Huijun Chen et al.   JOURNAL OF NUTRITION

Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents

(2010) M.F. Young et al.   PLACENTA

Placental efficiency and adaptation: endocrine regulation

(2009) A. L. Fowden et al.   JOURNAL OF PHYSIOLOGY-LONDON

Centrality of the Umbilical Cord Insertion in a Human Placenta Influences the Placental Efficiency☆

(2009) M. Yampolsky et al.   PLACENTA

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

(2009) G.J. Burton et al.   PLACENTA

The transplacental transport of essential amino acids in uncomplicated human pregnancies

(2008) Henry L. Galan et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY