Article
Environmental Sciences
Jiaojiao Guo, Jie Huang, Qian Wang, Lu Fang, Shenli Zhang, Bingshui Li, Liangju Lv, Meng Chen, Chonggang Wang
Summary: Exposure to phenanthrene during pregnancy can disturb glucose metabolism in adult offspring, with significant gender differences. Females show glucose intolerance, while males show abnormal blood glucose and insulin levels. Phenanthrene exposure also affects adipocytokine levels, which further influences visceral fat tissue.
Article
Endocrinology & Metabolism
Diego Hernandez-Saavedra, Christina Markunas, Hirokazu Takahashi, Lisa A. Baer, Johan E. Harris, Michael F. Hirshman, Olga Ilkayeva, Christopher B. Newgard, Kristin I. Stanford, Laurie J. Goodyear
Summary: It has been well established that maternal and paternal exercise can improve the metabolic health of adult offspring. However, little is known about how parental exercise affects the tissue and serum metabolites of offspring. In this study, researchers fed male and female breeders a high-fat diet and housed them with or without running wheels before breeding (for males) and before and during gestation (for females). The sedentary and chow-fed offspring were categorized into different groups based on their parents' exercise levels. The results showed that offspring from all parental exercise groups exhibited similar improvements in glucose tolerance and hepatic glucose production. Targeted metabolomics analysis revealed that offspring from different exercise groups had unique tissue metabolite signatures, with Mat+PatEx offspring showing an additive effect compared to MatEx or PatEx alone in some liver and muscle metabolites. The altered metabolites suggest that parental exercise enhances fatty acid oxidation. These findings provide valuable insights into tissue-specific adaptations and mechanisms underlying the improvement of offspring metabolic health induced by parental exercise, which may lead to the development of new therapeutic targets for metabolic diseases.
Article
Endocrinology & Metabolism
Mark H. Oliver, Anne L. Jaquiery, Kristin L. Connor, Hui Hui Phua, Jane E. Harding, Eric B. Thorstensen, Frank H. Bloomfield
Summary: Periconceptional undernutrition affects fetal hypothalamic-pituitary-adrenal axis function and placental glucocorticoid metabolism in sheep, but its effects on adult offspring are not known. This study found that PCUN did not significantly affect fetal adrenal development and cortisol regulation in adult offspring.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Siyuan Lv, Rui Qin, Yangqian Jiang, Hong Lv, Qun Lu, Shiyao Tao, Lei Huang, Cong Liu, Xin Xu, Qingru Wang, Mei Li, Zhi Li, Ye Ding, Ci Song, Tao Jiang, Hongxia Ma, Guangfu Jin, Yankai Xia, Zhixu Wang, Shanshan Geng, Jiangbo Du, Yuan Lin, Zhibin Hu
Summary: This study investigated the associations between maternal dietary patterns during different gestational periods and infant's neurodevelopment at 1 year of age. The results showed that adherence to the 'Aquatic products, Fresh vegetables and Homonemeae' dietary pattern in the second trimester and the 'Aquatic products and Homonemeae' pattern in the third trimester was associated with decreased risk of developmental delays in cognitive, gross motor, and receptive communication skills in infants.
Article
Biochemistry & Molecular Biology
Qingcai Chen, Wei Chu, Rui Sheng, Shaoyong Song, Jianping Yang, Fuhai Ji, Xin Jin
Summary: The study found that maternal anesthesia with sevoflurane could induce social interaction deficits in offspring mice, particularly impacting the preference for social novelty in a long-lasting manner.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Karolina Batista Nascimento, Matheus Castilho Galvao, Javier Andres Moreno Meneses, Gabriel Miranda Moreira, German Dario Ramirez-Zamudio, Stefania Priscilla de Souza, Ligia Dias Prezotto, Luthesco Haddad Lima Chalfun, Marcio de Souza Duarte, Daniel Rume Casagrande, Mateus Pies Gionbelli
Summary: This study evaluated the effects of maternal protein supplementation during mid-gestation on the offspring's feed intake parameters and found that protein supplementation can improve the performance and feed intake of the progeny. Additionally, protein restriction had different effects on the nutrient digestibility of female and male offspring.
Article
Developmental Biology
Linkai Zhu, Nicole Tillquist, Giovanna Scatolin, Rachael Gately, Mia Kawaida, Amanda Reiter, Sarah Reed, Steven Zinn, Kristen Govoni, Zongliang Jiang
Summary: Studies have shown that inadequate or excessive maternal nutrition during gestation does not affect semen characteristics in male sheep offspring, but it does result in significant changes in the composition and expression of small noncoding RNAs in sperm, as well as alterations in DNA methylation at specific genomic loci.
Article
Agriculture, Dairy & Animal Science
Tongxin Wang, Weilei Yao, Xiaomeng Liu, Zhengxi Bao, Chenrui Lv, Feiruo Huang
Summary: This study investigated the effects of embelin supplementation on the performance, immune and oxidative status, milk quality, and maternal-fetal glucose metabolism in sows during mid-to-late gestation. The results showed that embelin improved maternal immune and oxidative status, milk quality, and glucose metabolism in sows and piglets. This suggests that embelin may be a promising natural plant extractive for sows during mid-to-late pregnancy and lactation.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Sarah A. Reed, Jeremy Balsbaugh, Xiaomeng Li, Timothy E. Moore, Amanda K. Jones, Sambhu M. Pillai, Maria L. Hoffman, Kristen E. Govoni, Steven A. Zinn
Summary: Over- or restricted-nutrition during gestation alters the proteome of the longissimus dorsi muscle (LM) in offspring, affecting protein synthesis and degradation, stress responses, metabolism, and oxidative stress. These protein changes may contribute to the poor growth and development observed in the offspring.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Cell Biology
V. S. Jayalekshmi, Surya Ramachandran
Summary: This article discusses the potential impact of maternal hypercholesterolemia during pregnancy on fetal development and its associations with heart diseases, gestational diabetes, obesity, and other comorbidities.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Ana M. Realinho, Raquel Boia, Beatriz Paiva, Raquel G. Correia, Rita Gaspar, Antonio F. Ambrosio, Filipa I. Baptista
Summary: Maternal diabetes has negative effects on the offspring's brain, and this study reveals that it also impacts the development of the retina, leading to structural and functional deficits.
Article
Biochemistry & Molecular Biology
Xiaoyu Che, Ayan Roy, Michaeline Bresnahan, Siri Mjaaland, Ted Reichborn-Kjennerud, Per Magnus, Camilla Stoltenberg, Yimeng Shang, Keming Zhang, Ezra Susser, Oliver Fiehn, W. Ian Lipkin
Summary: The discovery of prenatal and neonatal molecular biomarkers has the potential to facilitate early diagnosis of autism spectrum disorder (ASD). In this study, metabolomic profiles in ASD were characterized using plasma samples from the Norwegian Autism Birth Cohort. Various chemical compounds and metabolite clusters were found to be associated with ASD, indicating inflammation, disruption of membrane integrity, impaired neurotransmission, and neurotoxicity. Machine learning algorithms showed promising results in distinguishing ASD cases from controls, particularly in cord blood analyses. These findings provide new insights into the sex-specific differences in ASD and may contribute to the development of early detection and intervention strategies.
MOLECULAR PSYCHIATRY
(2023)
Article
Genetics & Heredity
Yang Liu, Qiyue Ding, Steven J. Halderson, Sebastian I. Arriola Apelo, Amanda K. Jones, Sambhu M. Pillai, Maria L. Hoffman, Sarah Reed, Kristen E. Govoni, Steven A. Zinn, Wei Guo
Summary: Overfeeding during gestation can have long-lasting effects on offspring autophagy signaling, especially in later developmental stages and female offspring. Targeting autophagy pathways may be a strategy to mitigate the adverse effects in offspring of over-fed ewes.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Lamei Xue, Juan Sun, Jinxin Liu, Chaoping Hu, Dandan Wu, Chenzhipeng Nie, Kuiliang Zhang, Yu Wang, Lei Zhao, Xihua Li, Yan Lu, Li Zhang, Duo Zhang, Mingcong Fan, Haifeng Qian, Haowen Jiang, Jiemin Wong, Yuying Li, Hao Ying, Billy K. C. Chow, Li Wang, Yan Li
Summary: Our study reveals that overnutrition downregulates the expression of secretin (SCT), a brain-gut peptide, in pregnant mice and women. Loss of maternal SCT results in undesirable phenotypes in offspring, such as obesity and attenuated browning of iWAT. Mechanistically, SCT facilitates degradation of DNMT1 through AMPK alpha activation, leading to alterations in offspring's genome methylation pattern.
Article
Environmental Sciences
Xin Xu, Shiyao Tao, Lei Huang, Jiangbo Du, Cong Liu, Yangqian Jiang, Tao Jiang, Hong Lv, Qun Lu, Qingxia Meng, Xiaoyan Wang, Rui Qin, Hongxia Ma, Guangfu Jin, Yankai Xia, Haidong Kan, Yuan Lin, Rong Shen, Zhibin Hu
Summary: This study conducted a prospective birth cohort study in Jiangsu, China, and found that prenatal exposure to PM2.5, particularly with high sulfate concentration, was associated with non-optimal gross motor development in infants at 1 year old.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Letter
Allergy
Le Duc Huy Ta, James Chun Yip Chan, Gaik Chin Yap, Chiung-Hui Huang, Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Noor H. A. Suaini, Lynette P. Shek, Neerja Karnani, Anne Eng Neo Goh, Hugo P. S. Van Bever, Oon Hoe Teoh, Yiong Huak Chan, Christophe Lay, Jan Knol, Fabian Yap, Kok Hian Tan, Yap-Seng Chong, Mary Foong-Fong Chong, Shiao Yng Chan, Johan Gunnar Eriksson, Keith M. Godfrey, Eric Chun Yong Chan, Bee Wah Lee
Article
Nutrition & Dietetics
Yi Ying Ong, Wei Wei Pang, Navin Michael, Izzuddin M. Aris, Suresh Anand Sadananthan, Mya-Thway Tint, Jonathan Tze Liang Choo, Lieng Hsi Ling, Neerja Karnani, S. Sendhil Velan, Marielle V. Fortier, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith M. Godfrey, Shiao-Yng Chan, Johan G. Eriksson, Mary F-F Chong, Mary E. Wlodek, Yung Seng Lee
Summary: This study examined the effects of the timing of introduction of complementary foods and the duration of breastfeeding on body fat partitioning and cardiometabolic risk in children. The results showed that shorter breastfeeding duration and earlier introduction of complementary foods were associated with increased child adiposity and cardiometabolic risk. Longer duration of breastfeeding may protect against the cardiometabolic risk associated with early introduction of complementary foods.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Phillip E. E. Melton, M. A. Burton, K. A. Lillycrop, K. M. Godfrey, S. Rauschert, D. Anderson, G. C. Burdge, T. A. Mori, L. J. Beilin, O. T. Ayonrinde, J. M. Craig, J. K. Olynyk, J. D. Holbrook, C. E. Pennell, W. H. Oddy, E. K. Moses, L. A. Adams, R. C. Huang
Summary: Through DNA methylation epigenome-wide association study, we identified novel DNA methylation loci associated with NAFLD and serum liver biochemistry markers during adolescence, implicating putative dmCpG/gene regulatory pathways and providing insights for future mechanistic studies.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Psychiatry
Jian Huang, Ai Peng Tan, Evelyn Law, Keith M. Godfrey, Anqi Qiu, Lourdes Mary Daniel, Marielle Fortier, Kok Hian Tan, Jerry Kok Yen Chan, David Cameron-Smith, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Michael J. Meaney, Jonathan Huang
Summary: This study found that higher levels of certain nutrient-related biomarkers in maternal preconception blood were associated with an increased risk of behavioral problems in infants. The study also found that an increase in preconception thiamine levels was associated with higher CBCL scores and a lower right subthalamic nucleus ODI.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Stefanie N. Hinkle, Enrique F. Schisterman, Danping Liu, Anna Z. Pollack, Edwina H. Yeung, Sunni L. Mumford, Katherine L. Grantz, Yan Qiao, Neil J. Perkins, James L. Mills, Pauline Mendola, Cuilin Zhang
Summary: This study investigated the association between pregnancy complications and total and cause-specific mortality, as well as the differences between Black and White pregnant participants. The results showed that Black pregnant participants had a higher incidence of pregnancy complications, and the associations between different complications and mortality risk differed between Black and White participants.
Editorial Material
Endocrinology & Metabolism
Mireille N. M. van Poppel, Peter Damm, Elisabeth R. R. Mathiesen, Lene Ringholm, Cuilin Zhang, Gernot Desoye
Summary: In pregnancies of women with obesity or diabetes, neonates are often overgrown. This article focuses on possible growth deviations earlier in pregnancy and their potential contribution to neonatal overgrowth, suggesting that early-pregnancy growth reduction followed by in utero catch-up growth may confer a higher risk of obesity in later life.
Article
Environmental Sciences
Susanna D. Mitro, Rajeshwari Sundaram, Germaine M. Buck Louis, Shyamal Peddada, Zhen Chen, Kurunthachalam Kannan, Jessica L. Gleason, Cuilin Zhang, Katherine L. Grantz
Summary: This study found that certain PFAS were associated with growth in small fibroids and reduction in medium-sized fibroids. PFAS may influence existing fibroids rather than initiating fibroid development.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Allergy
Rachel L. Miller, Holly Schuh, Aruna Chandran, Izzuddin M. Aris, Casper Bendixsen, Jeffrey Blossom, Carrie Breton, Carlos A. Camargo Jr, Glorisa Canino, Kecia N. Carroll, Sarah Commodore, Jose F. Cordero, Dana M. Dabelea, Assiamira Ferrara, Rebecca C. Fry, Jody M. Ganiban, James E. Gern, Frank D. Gilliland, Diane R. Gold, Rima Habre, Marion E. Hare, Robyn N. Harte, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Daniel J. Jackson, Christine Joseph, Jean M. Kerver, Haejin Kim, Augusto A. Litonjua, Carmen J. Marsit, Cindy McEvoy, Eneida A. Mendonca, Paul E. Moore, Flory L. Nkoy, Thomas G. O'Connor, Emily Oken, Dennis Ownby, Matthew Perzanowski, Katherine Rivera-Spoljaric, Patrick H. Ryan, Anne Marie Singh, Joseph B. Stanford, Rosalind J. Wright, Robert O. Wright, Antonella Zanobetti, Edward Zoratti, Christine C. Johnson
Summary: This study found that the incidence rates of asthma with recurrent exacerbations (ARE) are influenced by time, geography, age, race and ethnicity, sex, and parental history. Children aged 2-4 years, Hispanic Black and non-Hispanic Black children, and those with a parental history of asthma had the highest rates of ARE.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Letter
Allergy
Zhao Xiang Choa, Gaik Chin Yap, Ruochen Du, Evelyn Xiu Ling Loo, Anne Eng Neo Goh, Oon Hoe Teoh, Hugo P. S. Van Bever, Lynette Pei-Chi Shek, Bee Wah Lee, Kok Hian Tan, Keith M. Godfrey, Johan Gunnar Eriksson, Yap Seng Chong, Shiao Yng Chan, Elizabeth Huiwen Tham
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Hui Xing Lau, Zhaojin Chen, Hugo Van Bever, Elizabeth Huiwen Tham, Yiong Huak Chan, Qai Ven Yap, Anne Eng Neo Goh, Oon Hoe Teoh, Kok Hian Tan, Fabian Kok Peng Yap, Keith M. Godfrey, Johan G. Eriksson, Yap Seng Chong, Bee Wah Lee, Lynette Pei-Chi Shek, Evelyn Xiu Ling Loo
Summary: Childhood wheezing is a highly heterogeneous condition, and wheeze trajectories vary. This study found that early-onset wheezing is associated with nonallergic rhinitis, while late-onset and persistent wheezing have similar origins characterized by parent-reported viral infections. However, persistent wheezing is generally more strongly associated with a family history of allergy, parent-reported viral infections, and allergic comorbidities compared to late-onset wheezing.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara E. Stinson, Jens-Christian Holm, Torben Hansen, Marie-France Hivert, Klaus Bonnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pediatrics
Kristen H. Shanahan, Peter James, Sheryl L. Rifas-Shiman, Diane R. Gold, Emily Oken, Izzuddin M. Aris
Summary: The study found that the neighborhood environment is associated with the presence of dampness or pests in the home. Better neighborhood conditions are associated with a lower likelihood of having dampness or pests in the home during early adolescence.
JOURNAL OF PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Jun S. Lai, Keith M. Godfrey, Choon Nam Ong, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Jerry K. Y. Chan, Shiao-Yng Chan, Mary F. -F. Chong
Summary: This study examined the associations between perinatal plasma carotenoids and E vitamers concentrations and glycemia, insulin resistance, and gestational and type 2 diabetes mellitus in GUSTO women. The findings suggest that higher concentrations of alpha- and beta-carotene and lutein may be beneficial for gestational fasting glycemia, while higher concentrations of vitamin E may increase gestational and post-pregnancy glycemia.
Article
Public, Environmental & Occupational Health
Anne H. Y. Chu, Natarajan Padmapriya, Shuen Lin Tan, Claire Marie J. L. Goh, Yap-Seng Chong, Lynette P. Shek, Kok Hian Tan, Peter D. Gluckman, Fabian K. P. Yap, Yung Seng Lee, See Ling Loy, Jerry K. Y. Chan, Keith M. Godfrey, Johan G. Eriksson, Shiao-Yng Chan, Jonathan Y. Bernard, Falk Muller-Riemenschneider
Summary: This study examined longitudinal changes in physical activity and sedentary behavior patterns from preconception to postpartum. The findings showed that walking time increased during late pregnancy, while vigorous-intensity physical activity and moderate to vigorous physical activity decreased but partially returned to preconception levels postpartum. Sedentary time remained stable during pregnancy but decreased postpartum. Individual characteristics such as ethnicity, body mass index, employment, parity, and self-rated general health significantly influenced women's activity patterns.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Health Care Sciences & Services
Sarah Yi Xuan Tan, Natarajan Padmapriya, Jonathan Y. Bernard, Jia Ying Toh, Hwee-Lin Wee, Kok Hian Tan, Fabian Kok Peng Yap, Yung Seng Lee, Yap-Seng Chong, Keith Godfrey, Johan Gunnar Eriksson, Lynette Pei-Chi Shek, Chuen Seng Tan, Mary Foong-Fong Chong, Falk Mueller-Riemenschneider
Summary: This study found that sleep and physical activity may be associated with better health-related quality of life (HRQoL) in children, while inactivity showed the opposite effect. However, the relationship between children's movement behaviours and HRQoL is complex and requires further research.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)