Article
Biochemistry & Molecular Biology
Brent A. Fujimoto, Madison Young, Nicole Nakamura, Herena Ha, Lamar Carter, Matthew W. Pitts, Daniel Torres, Hye-Lim Noh, Sujin Suk, Jason K. Kim, Noemi Polgar
Summary: This study demonstrates the importance of EXOC5 and the exocyst in insulin-stimulated glucose uptake in skeletal muscle cells. Deficiency of EXOC5 in skeletal muscle cells led to elevated fasting glucose levels, impaired glucose tolerance, and lower energy expenditure in mice. Overall, these findings suggest that EXOC5 and the exocyst play a crucial role in regulating glucose homeostasis in vivo.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Cell Biology
Adam Jaremek, Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Stephen J. Renaud
Summary: Proper development of the placenta, specifically the syncytiotrophoblast, is crucial for successful pregnancy as it regulates the exchange of nutrients and gases between maternal and fetal blood. Dysregulated formation of syncytiotrophoblast can have negative impacts on maternal and fetal health. 'Omics' approaches have been used to gain multidimensional insights into the formation and function of syncytiotrophoblast, but there are still limitations and future avenues for exploration in this area.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Jonathan S. S. Bogan
Summary: This article reviews recent advances in the mechanism of GLUT4 glucose transporter mobilization to enhance glucose uptake in response to insulin stimulation. The processing of TUG proteins plays a central role in regulating this process, with endoproteolytic cleavage of TUG mediated by the Usp25m protease being a key step in vesicle release. TUG processing also affects gene expression related to fatty acid oxidation and thermogenesis, further regulating energy metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Dougall Norris, Pengyi Yang, Sung-Young Shin, Alison L. Kearney, Hani Jieun Kim, Thomas Geddes, Alistair M. Senior, Daniel J. Fazakerley, Lan K. Nguyen, David E. James, James G. Burchfield
Summary: The study found that intercellular heterogeneity in insulin signaling primarily stems from variance in gene/protein expression between cells rather than within cells. This single-cell heterogeneity leads to differences in population response to insulin signaling.
Article
Biochemistry & Molecular Biology
Roni Rahimi, Israel Malek, Tali Lerrer-Goldshtein, Yoav Elkis, Irit Shoval, Avi Jacob, Sally Shpungin, Uri Nir
Summary: The study investigates the regulatory role of TMF1 in GLUT4-mediated glucose uptake and insulin-directed functioning, showing that TMF1 is essential for the formation of insulin responsive, GLUT4-containing vesicles. Absence of TMF1 leads to impaired glucose uptake, resulting in hyperglycemia and decreased body weight in mice, indicating a novel effector in insulin-regulated glucose homeostasis.
Article
Biochemistry & Molecular Biology
Sang R. Lee, Su Hee Jeong, Moeka Mukae, Kang Joo Jeong, Hyo-Jung Kwun, Eui-Ju Hong
Summary: This study establishes a moderate-obese diabetes model by inducing GLUT4 degradation with a chemical called GFI. GFI treatment leads to reduced GLUT4 levels, resulting in features of high blood glucose, insulin resistance, and decreased intracellular lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Cell Biology
Hannah L. Black, Rachel Livingstone, Cynthia C. Mastick, Mohammed Al Tobi, Holly Taylor, Angeline Geiser, Laura Stirrat, Dimitrios Kioumourtzoglou, John R. Petrie, James G. Boyle, Nia J. Bryant, Gwyn W. Gould
Summary: The knockout of syntaxin-4 in 3T3-L1 adipocytes was found to significantly reduce insulin-stimulated glucose transport and adiponectin secretion, but had only modest effects on the translocation capacity of the cells and the exocytic and endocytic rates of GLUT4.
JOURNAL OF CELL SCIENCE
(2022)
Article
Developmental Biology
Bianca Dietrich, Victoria Kunihs, Andreas I. Lackner, Gudrun Meinhardt, Bon-Kyoung Koo, Jurgen Pollheimer, Sandra Haider, Martin Knoefler
Summary: This study reveals that autocrine NOTCH3 signaling controls human placental development by promoting self-renewal of cytotrophoblast progenitors.
Article
Multidisciplinary Sciences
Ruth Hornbachner, Andreas Lackner, Henrieta Papuchova, Sandra Haider, Martin Knoefler, Karl Mechtler, Paulina A. Latos
Summary: The study identified MSX2 as a key transcriptional regulator of trophoblast identity, which can prevent premature syncytiotrophoblast differentiation. MSX2 co-operates with the SWI/SNF complex to regulate multiple differentiation genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Furong Liu, Ruyue He, Min Zhu, Lin Zhou, Yinghui Liu, Haijia Yu
Summary: In this study, the researchers found that Munc18c protein facilitates SNARE-dependent membrane fusion through an important peptide fragment called SLP. This discovery suggests that the t-SNARE-SLP binding mode might be a conserved mechanism for the stimulatory function of SM proteins in vesicle fusion.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Developmental Biology
Nobuko Mimura, Takeshi Nagamatsu, Kazuki Morita, Ayumi Taguchi, Takashi Toya, Keiichi Kumasawa, Takayuki Iriyama, Kei Kawana, Naoki Inoue, Tomoyuki Fujii, Yutaka Osuga
Summary: HCMV infection interferes with gene expression profiles and functional differentiation of trophoblasts, leading to placental dysfunction. HCMV infection suppresses trophoblast syncytialization and reduces the secretion of hCG and PlGF.
Article
Developmental Biology
Stanimir A. Tashev, Daisy Parsons, Cameron Hillman, Shelley Harris, Emma M. Lofthouse, Patricia Goggin, David S. Chatelet, Jane K. Cleal, Neil Smyth, Helen Palaiologou, Anton Page, Rohan M. Lewis
Summary: This study quantified the folding of the syncytiotrophoblast basal plasma membrane and its contribution to surface area, as well as visualized the three-dimensional structure of the basal membrane and cytotrophoblast cells. The findings suggest that the folding of the basal membrane significantly increases its surface area, potentially affecting nutrient transport capacity and fetal growth.
Article
Biochemistry & Molecular Biology
Vance Holt, Bjorn Moren, Claes Fryklund, Robert A. Colbert, Karin G. Stenkula
Summary: During inflammation, IFN gamma and TNF can rapidly induce glucose uptake and glycolysis in keratinocytes, which may contribute to inflammation in psoriatic disease.
Article
Nanoscience & Nanotechnology
Valentina Fokina, Svetlana Patrikeeva, Xiaoming Wang, Mansi Shah, Poonam Shah, William K. Russell, Mahmoud S. Ahmed, Erik Rytting, Tatiana Nanovskaya
Summary: The purpose of this study was to characterize membrane vesicles obtained from human placenta and explore their potential as biological vehicles for drug delivery. The vesicles showed stability, low toxicity, and low immunogenicity, making them suitable for further development. Additionally, the vesicles were found to distribute to various organs within 24 hours of administration. These findings suggest that placental membrane vesicles have promising applications in drug delivery.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
Ariel Sklar, Jeanelle Sheeder, Anne R. Davis, Carrie Wilson, Stephanie B. Teal
Summary: This study compared maternal morbidity in women with preterm premature rupture of membranes who chose either expectant management or termination of pregnancy. The results showed that women who chose expectant management had higher morbidity rates, with an increased risk of chorioamnionitis and postpartum hemorrhage compared to those who chose termination of pregnancy. Expectant management was also associated with a higher likelihood of admission to the maternal intensive care unit and unplanned hysterectomy. The study suggests that expectant management increases maternal morbidity compared to termination of pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal
Summary: This study assessed the variability of repeated measurements of serum etonogestrel concentration among contraceptive implant users and confirmed that single-time measurements are acceptable pharmacokinetic outcomes.
Article
Nutrition & Dietetics
Ellen C. Francis, Dana Dabelea, Kristen E. Boyle, Thomas Jansson, Wei Perng
Summary: Maternal diet quality has sex-specific associations with placental protein abundance and phosphorylation. These proteins are also correlated with neonatal anthropometry, providing insight into potential links between maternal diet and offspring metabolic health for future studies.
JOURNAL OF NUTRITION
(2022)
Article
Obstetrics & Gynecology
Carolyn L. Westhoff, David F. Archer, Kurt Barnhart, Philip Darney, Melissa Gilliam, Jeffrey Jensen, Anita Nelson, Stephanie Teal, Michael Thomas, Jack Hu, Jill Brown, Diana L. Blithe
Summary: Daily oral ulipristal acetate effectively inhibits ovulation and is safe to use, although the dosage and treatment period may affect its efficacy. Some participants experienced reversible endometrial changes during treatment, which resolved after treatment cessation.
Editorial Material
Medicine, General & Internal
Rebecca H. Cohen, Stephanie B. Teal
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Letter
Medicine, General & Internal
Stephanie Teal, Alison Edelman
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Obstetrics & Gynecology
Aaron Lazorwitz, Morgan Pena, Jeanelle Sheeder, Stephanie Teal
Summary: The pharmacokinetic interaction between topiramate and etonogestrel in contraceptive implant users resulted in decreased serum etonogestrel concentrations, potentially impacting contraceptive efficacy.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Taylor Burger, Joanna Li, Qiuhong Zhao, Courtney A. Schreiber, Stephanie Teal, David K. Turok, Melissa Natavio, Jeffrey F. Peipert
Summary: This study suggests that obesity is associated with increased time to pregnancy in participants who stop contraception to attempt pregnancy.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Shanthie Thamotharan, Shubhamoy Ghosh, Laura James-Allan, Margarida Y. Y. Lei, Carla Janzen, Sherin U. U. Devaskar
Summary: The study found that circulating extracellular vesicles (EVs) carrying specific non-coding microRNA signatures originating from the placenta may contribute to the development of gestational diabetes mellitus (GDM). Differences in miRNA expression between pregnant and non-pregnant states were observed, with several miRNAs originating from placental-specific microRNA clusters. The miRNAs targeted genes involved in cell metabolism, proliferation, and immune tolerance, suggesting a role for placental communication with maternal organs in the pathogenesis of GDM.
Review
Public, Environmental & Occupational Health
Dustin Costescu, Rajinder Chawla, Rowena Hughes, Stephanie Teal, Martin Merz
Summary: This systematic literature review investigated whether differences in bleeding patterns influence continuation rates of LNG-IUDs and Cu-IUDs in women in America, Europe and Australia.
Letter
Obstetrics & Gynecology
Ariel Sklar, Stephanie Teal, Jeanelle Sheeder
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Kathryn J. Lindley, Stephanie B. Teal
Summary: This article provides a summary of the prevalence of cardiovascular disease among women of childbearing age, the most effective forms of contraception based on the patient's medical condition and preference, and the risks and adverse effects associated with contraindicated forms of contraception.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Cara Clure, Jeanelle Sheeder, Stephanie Teal, Rebecca Cohen
Summary: This study aimed to evaluate rural Colorado women's access to and preferences for reproductive health care services. The survey found that most women identified barriers to obtaining reproductive care in their communities, with too few community-based providers and long distance to care being the most common barriers. More than half of the women were interested in using telemedicine for reproductive health care, but there was also a portion who were not interested.
JOURNAL OF RURAL HEALTH
(2023)
Review
Obstetrics & Gynecology
Alexandra Wollum, Carmela Zuniga, Kelly Blanchard, Stephanie Teal
Summary: Clinical guidelines for progestin-only pills (POPs) recommend taking each pill at the same time daily, with only a three-hour window of tolerance before using back-up contraception. This commentary summarizes studies on timing of ingestion and mechanisms of action for different POP formulations and dosages. It highlights that different progestins have varying effects on pregnancy prevention when pills are delayed or missed, suggesting that the three-hour window recommendation should be re-evaluated.
Review
Developmental Biology
Avery C. Kramer, Thomas Jansson, Tracy L. Bale, Theresa L. Powell
Summary: Altered placental function may mediate the link between the maternal environment and fetal growth and development, through nutrient sensing, modulation of transporters, and changes in extracellular vesicles. Maternal diet and stress can also influence fetal development and metabolism, and fetal growth restriction may increase the risk of chronic disease later in life.