Th17 Cells Pathways in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Pathophysiological and Therapeutic Implications

Prediction of disease severity in neuromyelitis optica by the levels of interleukin (IL)-6 produced during remission phase

(2015) P. O. Barros et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The role of Th17 cells in patients with relapsing-remitting multiple sclerosis: Interleukin-17A and interleukin-17F serum levels

(2015) Zohreh Babaloo et al.   IMMUNOLOGY LETTERS

Resolution of aquaporin-4 antibodies in a woman with neuromyelitis optica treated with human autologous stem cell transplant

(2015) Patrick Aouad et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cambios en las Subpoblaciones de Linfocitos B y T en el Título de Anticuerpos Anti-Acuaporina-4 tras el Tratamiento de un Brote Agudo con Inmunoglobulinas y Rituximab

(2015) C. de Andrés et al.   NEUROLOGIA

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

(2015) Dean M. Wingerchuk et al.   NEUROLOGY

Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica

(2015) Melina V Jones et al.   Acta Neuropathologica Communications

STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation

(2014) Wanqiang Sheng et al.   CELL RESEARCH

IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments

(2014) Dirk W. Luchtman et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Th17 cells in central nervous system autoimmunity

(2014) Christopher Sie et al.   EXPERIMENTAL NEUROLOGY

The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

(2014) Gaelle Elain et al.   GLIA

VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells

(2014) Tilman Schneider-Hohendorf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis

(2014) Douglas Kazutoshi Sato et al.   JOURNAL OF NEUROIMMUNOLOGY

Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis

(2014) R. Ratzer et al.   JOURNAL OF NEUROIMMUNOLOGY

Sodium intake is associated with increased disease activity in multiple sclerosis

(2014) Mauricio F Farez et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Catastrophic brain relapse in seronegative NMO after a single dose of natalizumab

(2014) Joanna Kitley et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Autologous hematopoietic stem cell transplantation in neuromyelitis optica: A registry study of the EBMT Autoimmune Diseases Working Party

(2014) Raffaella Greco et al.   Multiple Sclerosis Journal

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies

(2014) Marios C. Papadopoulos et al.   Nature Reviews Neurology

Poor Responses to Interferon-Beta Treatment in Patients with Neuromyelitis Optica and Multiple Sclerosis with Long Spinal Cord Lesions

(2014) Kai-Chen Wang et al.   PLoS One

Rituximab modulates IL-17 expression in the salivary glands of patients with primary Sjögren’s syndrome

(2014) Francesco Ciccia et al.   RHEUMATOLOGY

The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis

(2014) G. Guggino et al.   RHEUMATOLOGY INTERNATIONAL

Immunology of neuromyelitis optica: a T cell-B cell collaboration

(2013) Meike Mitsdoerffer et al.   Annals of the New York Academy of Sciences

Experimental Models of Neuromyelitis Optica

(2013) Monika Bradl et al.   BRAIN PATHOLOGY

The impact of conventional DMARD and biological therapies on CD4+ cell subsets in rheumatoid arthritis: a follow-up study

(2013) Balázs Szalay et al.   CLINICAL RHEUMATOLOGY

Remote control—triggering of brain autoimmune disease in the gut

(2013) Hartmut Wekerle et al.   CURRENT OPINION IN IMMUNOLOGY

Treating multiple sclerosis with monoclonal antibodies: a 2013 update

(2013) Annika Deiß et al.   Expert Review of Neurotherapeutics

High in vitro immune reactivity to Escherichia coli in neuromyelitis optica patients is correlated with both neurological disabilities and elevated plasma lipopolysaccharide levels

(2013) Priscila O. Barros et al.   HUMAN IMMUNOLOGY

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica

(2013) Hua Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuromyelitis optica: Concept, immunology and treatment

(2013) Akiyuki Uzawa et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Distinct Serum Cytokine Profiles in Neuromyelitis Optica and Multiple Sclerosis

(2013) Kai Chen Wang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination

(2013) Abdolmohamad Rostami et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17- and Activated B-Cells and Correlates with Progression

(2013) Jeppe Romme Christensen et al.   PLoS One

Characteristic Cerebrospinal Fluid Cytokine/Chemokine Profiles in Neuromyelitis Optica, Relapsing Remitting or Primary Progressive Multiple Sclerosis

(2013) Takuya Matsushita et al.   PLoS One

Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognizeClostridiumABC transporter

(2012) Michel Varrin-Doyer et al.   ANNALS OF NEUROLOGY

Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation

(2012) Peter J. Darlington et al.   ANNALS OF NEUROLOGY

Effect of IL-17A blockade with secukinumab in autoimmune diseases

(2012) Dhavalkumar D Patel et al.   ANNALS OF THE RHEUMATIC DISEASES

Failure of Natalizumab to Prevent Relapses in Neuromyelitis Optica

(2012) Ingo Kleiter   ARCHIVES OF NEUROLOGY

Type I Interferons: Beneficial in Th1 and Detrimental in Th17 Autoimmunity

(2012) Robert C. Axtell et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Molecular Pathogenesis of Neuromyelitis Optica

(2012) Wajih Bukhari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory Effect of IVIG on IL-17 Production by Th17 Cells is Independent of Anti-IL-17 Antibodies in the Immunoglobulin Preparations

(2012) Mohan S. Maddur et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Ex Vivo Production of IL-6 and IL-21 by CD4+ T Cells is Directly Associated with Neurological Disability in Neuromyelitis Optica Patients

(2012) Ulisses C. Linhares et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Late Breaking News 1

(2012)   Multiple Sclerosis Journal

Does interferon beta treatment exacerbate neuromyelitis optica spectrum disorder?

(2012) Su-Hyun Kim et al.   Multiple Sclerosis Journal

T cells become licensed in the lung to enter the central nervous system

(2012) Francesca Odoardi et al.   NATURE

Serum IL-17F does not predict poor response to IM IFN -1a in relapsing-remitting MS

(2012) S. E. Bushnell et al.   NEUROLOGY

Pathogenic T cell responses against aquaporin 4

(2011) Maria Pohl et al.   ACTA NEUROPATHOLOGICA

Failure of Autologous Hematopoietic Stem Cell Transplantation to Prevent Relapse of Neuromyelitis Optica

(2011) Marcelo Matiello   ARCHIVES OF NEUROLOGY

The anti-CD20 antibody rituximab reduces the Th17 cell response

(2011) Frank L. van de Veerdonk et al.   ARTHRITIS AND RHEUMATISM

IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells

(2011) Cheryl M. Sweeney et al.   BRAIN BEHAVIOR AND IMMUNITY

Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica

(2011) N. Matsuya et al.   INTERNATIONAL IMMUNOLOGY

Inhibition of differentiation, amplification, and function of human TH17 cells by intravenous immunoglobulin

(2011) Mohan S. Maddur et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-17-secreting T cells in neuromyelitis optica and multiple sclerosis during relapse

(2011) H.H. Wang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis

(2011) Ying Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Glatiramer acetate could be a hypothetical therapeutic agent for neuromyelitis optica

(2011) Kai-Chen Wang et al.   MEDICAL HYPOTHESES

Massive astrocyte destruction in neuromyelitis optica despite natalizumab therapy

(2011) MH Barnett et al.   Multiple Sclerosis Journal

Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder

(2011) Ju-Hong Min et al.   Multiple Sclerosis Journal

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Methotrexate attenuates the Th17/IL-17 levels in peripheral blood mononuclear cells from healthy individuals and RA patients

(2011) Yanshan Li et al.   RHEUMATOLOGY INTERNATIONAL

FTY720 Regulates Bone Marrow Egress of Eosinophils and Modulates Late-Phase Skin Reaction in Mice

(2010) Kazunari Sugita et al.   AMERICAN JOURNAL OF PATHOLOGY

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

(2010) Áine C. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

Substance P Enhances Th17 Phenotype in Individuals with Generalized Anxiety Disorder: an Event Resistant to Glucocorticoid Inhibition

(2010) Priscila O. Barros et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing–remitting or chronic EAE

(2010) Rina Aharoni et al.   JOURNAL OF NEUROIMMUNOLOGY

Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6

(2010) Akiyuki Uzawa et al.   Multiple Sclerosis Journal

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

A Preliminary Result of Treatment of Neuromyelitis Optica With Autologous Peripheral Hematopoietic Stem Cell Transplantation

(2010) Fuhua Peng et al.   NEUROLOGIST

IFN -1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum

(2010) J. Shimizu et al.   NEUROLOGY

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

Immunodominant T Cell Determinants of Aquaporin-4, the Autoantigen Associated with Neuromyelitis Optica

(2010) Patricia A. Nelson et al.   PLoS One

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Helena S. Domingues et al.   PLoS One

Effect of high-dose methylprednisolone treatment on Th17 cells in patients with multiple sclerosis in relapse

(2009) M. Liu et al.   ACTA NEUROLOGICA SCANDINAVICA

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Interferon-β1b Treatment in Neuromyelitis Optica

(2009) Masami Tanaka et al.   EUROPEAN NEUROLOGY

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

IFN-  Inhibits Human Th17 Cell Differentiation

(2009) V. S. Ramgolam et al.   JOURNAL OF IMMUNOLOGY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells

(2008) Monica Montes et al.   CLINICAL IMMUNOLOGY

T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

(2008) Chris J. Hedegaard et al.   IMMUNOLOGY

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

(2008) Beichu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

GM-CSF mediates autoimmunity by enhancing IL-6–dependent Th17 cell development and survival

(2008) Ivo Sonderegger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Th17–ELR+CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

(2008) Thaddeus Carlson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis

(2008) M. Tanaka et al.   NEUROLOGY

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY