Integrative multi‐omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention‐Deficit/Hyperactivity Disorder

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

(2023) Ditte Demontis et al.   NATURE GENETICS

Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children

(2022) Fiona A. Hagenbeek et al.   Metabolites

Comprehensive analysis of omics data identifies relevant gene networks for Attention-Deficit/Hyperactivity Disorder (ADHD)

(2022) Judit Cabana-Domínguez et al.   Translational Psychiatry

Integrative Multi-omics Analysis of Childhood Aggressive Behavior

(2022) Fiona A. Hagenbeek et al.   BEHAVIOR GENETICS

Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

(2021) Ditte Demontis et al.   Nature Communications

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

(2021) Monica del C. Gomez-Alonso et al.   Clinical Epigenetics

The World Federation of ADHD International Consensus Statement: 208 Evidence-based Conclusions about the Disorder

(2021) Stephen V. Faraone et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Proteome-wide Association Study Provides Insights Into the Genetic Component of Protein Abundance in Psychiatric Disorders

(2021) Jiewei Liu et al.   BIOLOGICAL PSYCHIATRY

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

(2021) Josine L. Min et al.   NATURE GENETICS

Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders

(2021) Mei-Ching Yu et al.   Scientific Reports

Genetic association study of childhood aggression across raters, instruments, and age

(2021) Hill F. Ip et al.   Translational Psychiatry

Navigating the pitfalls of applying machine learning in genomics

(2021) Sean Whalen et al.   NATURE REVIEWS GENETICS

EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study

(2021) Zhuang Xiong et al.   NUCLEIC ACIDS RESEARCH

Intergenerational Transmission of Education and ADHD: Effects of Parental Genotypes

(2020) Eveline L. de Zeeuw et al.   BEHAVIOR GENETICS

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

(2020) Fiona A. Hagenbeek et al.   Nature Communications

Genetics of ADHD: What Should the Clinician Know?

(2020) Oliver Grimm et al.   Current Psychiatry Reports

Large epigenome-wide association study of childhood ADHD identifies peripheral DNA methylation associated with disease and polygenic risk burden

(2020) Michael A. Mooney et al.   Translational Psychiatry

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

(2020) Paula Rovira et al.   NEUROPSYCHOPHARMACOLOGY

Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets

(2020) Shiqiang Cheng et al.   SCHIZOPHRENIA BULLETIN

Novel plasma metabolite markers of attention-deficit/hyperactivity disorder identified using high-performance chemical isotope labelling-based liquid chromatography-mass spectrometry

(2020) Liang-Jen Wang et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study

(2020) Fiona A. Hagenbeek et al.   Frontiers in Psychiatry

A powerful framework for an integrative study with heterogeneous omics data: from univariate statistics to multi-block analysis

(2020) Harold Duruflé et al.   BRIEFINGS IN BIOINFORMATICS

Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults

(2020) Paula Rovira et al.   Translational Psychiatry

Multi-omics integration in biomedical research – A metabolomics-centric review

(2020) Maria A. Wörheide et al.   ANALYTICA CHIMICA ACTA

Maternal and cord plasma branched‐chain amino acids and child risk of attention‐deficit hyperactivity disorder: a prospective birth cohort study

(2020) Neha S. Anand et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation

(2020) Sarah J. Goodman et al.   Journal of Neurodevelopmental Disorders

DIABLO: an integrative approach for identifying key molecular drivers from multi-omic assays

(2019) Amrit Singh et al.   BIOINFORMATICS

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Multivariate genome-wide analyses of the well-being spectrum

(2019) Bart M. L. Baselmans et al.   NATURE GENETICS

Genome‐wide DNA methylation investigation of glucocorticoid exposure within buccal samples

(2019) Patricia R. Braun et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

(2019) Philip R. Jansen et al.   NATURE GENETICS

A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD)

(2019) Yuyang Luo et al.   Frontiers in Human Neuroscience

Epigenome-wide association study of ADHD symptoms in adults

(2019) Jenny van Dongen et al.   BIOLOGICAL PSYCHIATRY

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

Genetic Similarity Assessment of Twin-Family Populations by Custom-Designed Genotyping Array

(2019) Jeffrey J. Beck et al.   Twin Research and Human Genetics

Epigenome-wide Associations With Attention-Deficit/Hyperactivity Disorder in Adults: The Need for a Longitudinal Life Course Approach in Epigenetic Psychiatry

(2019) Esther Walton   BIOLOGICAL PSYCHIATRY

The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs

(2019) Lannie Ligthart et al.   Twin Research and Human Genetics

omicsPrint: detection of data linkage errors in multiple omics studies

(2018) Maarten van Iterson et al.   BIOINFORMATICS

Meffil: efficient normalization and analysis of very large DNA methylation datasets

(2018) J L Min et al.   BIOINFORMATICS

Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3–16 years from multiple raters in six cohorts in the EU-ACTION project

(2018) Meike Bartels et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Genetics of attention deficit hyperactivity disorder

(2018) Stephen V. Faraone et al.   MOLECULAR PSYCHIATRY

Treatment strategies for ADHD: an evidence-based guide to select optimal treatment

(2018) Arthur Caye et al.   MOLECULAR PSYCHIATRY

Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets

(2018) Ricard Argelaguet et al.   Molecular Systems Biology

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

(2018) Jeanne E. Savage et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

The nature of nurture: Effects of parental genotypes

(2018) Augustine Kong et al.   SCIENCE

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Onco-Multi-OMICS Approach: A New Frontier in Cancer Research

(2018) Sajib Chakraborty et al.   Biomed Research International

Comorbidity prevalence and treatment outcome in children and adolescents with ADHD

(2017) Laura Reale et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Epigenetics and ADHD

(2017) Meriem Hamza et al.   Journal of Attention Disorders

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder

(2017) M Ikeda et al.   MOLECULAR PSYCHIATRY

Metabolomics: A Primer

(2017) Xiaojing Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder

(2017) Cristian Bonvicini et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

mixOmics: An R package for ‘omics feature selection and multiple data integration

(2017) Florian Rohart et al.   PLoS Computational Biology

Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry

(2016) Fiona A. Hagenbeek et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

More effort — more results: recent advances in integrative ‘omics’ data analysis

(2016) Dhivyaa Rajasundaram et al.   CURRENT OPINION IN PLANT BIOLOGY

A method to customize population-specific arrays for genome-wide association testing

(2016) Erik A Ehli et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems

(2016) Jolien Rijlaarsdam et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

(2016) Christel M. Middeldorp et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study

(2016) E Walton et al.   MOLECULAR PSYCHIATRY

Erratum: Attention-deficit hyperactivity disorder in adults: a systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies

(2016) C Bonvicini et al.   MOLECULAR PSYCHIATRY

Fast and accurate long-range phasing in a UK Biobank cohort

(2016) Po-Ru Loh et al.   NATURE GENETICS

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

(2016) Nicola Barban et al.   NATURE GENETICS

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences

(2016) Sebastian Moran et al.   Epigenomics

Genetic and environmental influences interact with age and sex in shaping the human methylome

(2016) Jenny van Dongen et al.   Nature Communications

dendextend: an R package for visualizing, adjusting and comparing trees of hierarchical clustering

(2015) Tal Galili   BIOINFORMATICS

MethylAid: visual and interactive quality control of large Illumina 450k datasets

(2014) M. van Iterson et al.   BIOINFORMATICS

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Population structure, migration and diversifying selection in the Netherlands

(2013) Abdel Abdellaoui et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The Genome of the Netherlands: design, and project goals

(2013) Dorret I Boomsma et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Oxidative Stress and ADHD

(2013) Nidhin Joseph et al.   Journal of Attention Disorders

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

(2013) B Benyamin et al.   MOLECULAR PSYCHIATRY

American Psychiatric Association explains DSM-5

(2013) B. Roehr   BMJ-British Medical Journal

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children

(2012) Catharina E. M. van Beijsterveldt et al.   Twin Research and Human Genetics

Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: A genetic analysis of comorbidity

(2011) Marijn A. Distel et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

ADHD and genetic syndromes

(2010) Adriana Lo-Castro et al.   BRAIN & DEVELOPMENT

Coexisting Psychiatric Problems and Stressful Life Events in Adults With Symptoms of ADHD—A Large Swedish Population-Based Study of Twins

(2010) Bettina Friedrichs et al.   Journal of Attention Disorders

Epigenetics: Connecting Environment and Genotype to Phenotype and Disease

(2009) S.P. Barros et al.   JOURNAL OF DENTAL RESEARCH