Proteome-wide Association Study Provides Insights Into the Genetic Component of Protein Abundance in Psychiatric Disorders

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis

(2021) Aliza P. Wingo et al.   NATURE GENETICS

A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression

(2021) Yifan Li et al.   MOLECULAR PSYCHIATRY

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression

(2021) Xiaoyan Li et al.   Translational Psychiatry

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

(2020) Aliza P. Wingo et al.   NATURE NEUROSCIENCE

DARS2 is indispensable for Purkinje cell survival and protects against cerebellar ataxia

(2020) Anastasia Rumyantseva et al.   HUMAN MOLECULAR GENETICS

A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density

(2020) Xin Cai et al.   SCHIZOPHRENIA BULLETIN

Delineating the Genetic Component of Gene Expression in Major Depression

(2020) Lorenza Dall’Aglio et al.   BIOLOGICAL PSYCHIATRY

Integration of the Drug–Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts

(2020) Sharon L Freshour et al.   NUCLEIC ACIDS RESEARCH

Opportunities and challenges for transcriptome-wide association studies

(2019) Michael Wainberg et al.   NATURE GENETICS

Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions

(2019) Summer B. Thyme et al.   CELL

Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits

(2019) Eric R. Gamazon et al.   NATURE GENETICS

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms

(2019) Rebecca L. Walker et al.   CELL

A Transcriptome-Wide Association Study implicates specific pre- and post-synaptic abnormalities in Schizophrenia

(2019) Lynsey S Hall et al.   HUMAN MOLECULAR GENETICS

The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine

(2019) Zhihui Yang et al.   MOLECULAR PSYCHIATRY

Comparative genetic architectures of schizophrenia in East Asian and European populations

(2019) Max Lam et al.   NATURE GENETICS

Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

(2019) Calwing Liao et al.   Nature Communications

CNNM2 homozygous mutations cause severe refractory hypomagnesemia, epileptic encephalopathy and brain malformations

(2018) Andrea Accogli et al.   European Journal of Medical Genetics

Religious Orders Study and Rush Memory and Aging Project

(2018) David A. Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

(2018) Lang Wu et al.   NATURE GENETICS

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

(2018) Alexander Gusev et al.   NATURE GENETICS

Systems-level analysis of risk genes reveals the modular nature of schizophrenia

(2018) Jiewei Liu et al.   SCHIZOPHRENIA RESEARCH

Drug Targetor: a web interface to investigate the human druggome for over 500 phenotypes

(2018) Héléna A Gaspar et al.   BIOINFORMATICS

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

On the Dependency of Cellular Protein Levels on mRNA Abundance

(2016) Yansheng Liu et al.   CELL

The economic costs of mental disorders

(2016) Sebastian Trautmann et al.   EMBO REPORTS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

(2015) Thomas G. Beach et al.   NEUROPATHOLOGY

Magnesium in Man: Implications for Health and Disease

(2015) Jeroen H. F. de Baaij et al.   PHYSIOLOGICAL REVIEWS

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast

(2015) Gábor Csárdi et al.   PLoS Genetics

Genetics of single-cell protein abundance variation in large yeast populations

(2014) Frank W. Albert et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Impact of regulatory variation from RNA to protein

(2014) A. Battle et al.   SCIENCE

CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia

(2014) Francisco J. Arjona et al.   PLoS Genetics

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

(2013) Xin He et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style

(2013) Emma Jane Rose et al.   BRITISH JOURNAL OF PSYCHIATRY

Ribosome profiling reveals post-transcriptional buffering of divergent gene expression in yeast

(2013) C. J. McManus et al.   GENOME RESEARCH

Evolution at two levels of gene expression in yeast

(2013) C. G. Artieri et al.   GENOME RESEARCH

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010

(2013) Harvey A Whiteford et al.   LANCET

Membrane Topology and Intracellular Processing of Cyclin M2 (CNNM2)

(2012) Jeroen H. F. de Baaij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

(2012) Christine Vogel et al.   NATURE REVIEWS GENETICS

CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia

(2011) Marchel Stuiver et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Comparative Analysis of Proteome and Transcriptome Variation in Mouse

(2011) Anatole Ghazalpour et al.   PLoS Genetics