Drug repositioning strategy for the identification of novel telomere‐damaging agents: A role for NAMPT inhibitors

Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

(2022) Florian J Groelly et al.   EMBO Molecular Medicine

NAMPT: A critical driver and therapeutic target for cancer

(2022) Massimiliano Gasparrini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Telomere Targeting Approaches in Cancer: Beyond Length Maintenance

(2022) Eleonora Vertecchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Updated Functional Roles of NAMPT in Carcinogenesis and Therapeutic Niches

(2022) Tsung-Chieh Lin   Cancers

MiR ‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer

(2022) Roberto Dinami et al.   EMBO Molecular Medicine

Telomeres: history, health, and hallmarks of aging

(2021) Deepavali Chakravarti et al.   CELL

Advances in NAD-Lowering Agents for Cancer Treatment

(2021) Moustafa S. Ghanem et al.   Nutrients

A Novel Screen for Expression Regulators of the Telomeric Protein TRF2 Identified Small Molecules That Impair TRF2 Dependent Immunosuppression and Tumor Growth

(2021) Mounir El Maï et al.   Cancers

Telomerase-based cancer therapeutics: a review on their clinical trials

(2020) Nicola Relitti et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy

(2020) Christine M. Heske   Frontiers in Oncology

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy

(2020) Ubaldina Galli et al.   Frontiers in Pharmacology

The Role of Alternative Lengthening of Telomeres Mechanism in Cancer: Translational and Therapeutic Implications

(2020) Marta Recagni et al.   Cancers

The end protection problem—an unexpected twist in the tail

(2020) Phil Ruis et al.   GENES & DEVELOPMENT

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

(2019) Elise Fouquerel et al.   MOLECULAR CELL

Multiple cancer pathways regulate telomere protection

(2019) Leire Bejarano et al.   EMBO Molecular Medicine

An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks

(2019) Jun Tan et al.   NUCLEIC ACIDS RESEARCH

Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent

(2019) Anne-Julie Cloux et al.   Oncotarget

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of NAMPT decreases cell growth and enhances susceptibility to oxidative stress

(2017) Renhua Xu et al.   ONCOLOGY REPORTS

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

(2016) Alejandra Bruna et al.   CELL

NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer

(2015) S M Hong et al.   ONCOGENE

Oxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian Cells

(2014) Elisa Coluzzi et al.   PLoS One

A qPCR-based assay to quantify oxidized guanine and other FPG-sensitive base lesions within telomeric DNA

(2012) Nathan O’Callaghan et al.   BIOTECHNIQUES

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Niacin Status, NAD Distribution and ADP-Ribose Metabolism

(2009) James Kirkland   CURRENT PHARMACEUTICAL DESIGN

Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1

(2008) Sascha Beneke et al.   NUCLEIC ACIDS RESEARCH