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Glucose-Regulated Protein 78 Is a Potential Serum and Imaging Marker for Early Detection of Ovarian Cancer

(2023) Elizabeth A. Paris et al.   Cancers

Schizophrenia

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Reduction in Multiple Cardiometabolic Risk Factors With Combined Olanzapine/Samidorphan Compared With Olanzapine: Post Hoc Analyses From a 24-Week Phase 3 Study

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Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight

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Atypical Antipsychotics and Metabolic Syndrome: From Molecular Mechanisms to Clinical Differences

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Antipsychotic Polypharmacy for the Management of Schizophrenia: Evidence and Recommendations

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Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response

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Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

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ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development

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The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

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Epigenetic histone modulations of PPARγ and related pathways contribute to olanzapine-induced metabolic disorders

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Increased Appetite Plays a Key Role in Olanzapine-Induced Weight Gain in

(2020) Jing Huang et al.   Frontiers in Pharmacology

Effects of Olanzapine Combined With Samidorphan on Weight Gain in Schizophrenia: A 24-Week Phase 3 Study

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Pharmacological Management of Glucose Dysregulation in Patients Treated with Second-Generation Antipsychotics

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Impact of Psychotropic Medication Effects on Obesity and the Metabolic Syndrome in People With Serious Mental Illness

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Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

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Antipsychotics Promote Metabolic Disorders Disrupting Cellular Lipid Metabolism and Trafficking

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Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway

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Are There Gender Differences in the Response to Antipsychotic Drugs?

(2019) Mary V. Seeman   NEUROPHARMACOLOGY

Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate

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Association With Hospitalization and All-Cause Discontinuation Among Patients With Schizophrenia on Clozapine vs Other Oral Second-Generation Antipsychotics

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Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

Activation of G0/G1 switch gene 2 by endoplasmic reticulum stress enhances hepatic steatosis

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The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario

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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

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A Randomized, Placebo-Controlled Trial of Metformin for the Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorder: Open-Label Extension

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Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress

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Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implications

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Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKα-SREBP-1 and PPARα-dependent pathways

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Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology

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Association between SREBF2 gene polymorphisms and metabolic syndrome in clozapine-treated patients with schizophrenia

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Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine

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Acute Effects of Single-Dose Olanzapine on Metabolic, Endocrine, and Inflammatory Markers in Healthy Controls

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Pharmacogenomics of sterol synthesis and statin use in schizophrenia subjects treated with antipsychotics

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Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats

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A Double Blind, Placebo-Controlled, Randomized Crossover Study of the Acute Metabolic Effects of Olanzapine in Healthy Volunteers

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Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol

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Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia

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Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples

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