PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

The complex link between NAFLD and type 2 diabetes mellitus — mechanisms and treatments

(2021) Giovanni Targher et al.   Nature Reviews Gastroenterology & Hepatology

“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis

(2021) Mark A. Febbraio et al.   Cell Metabolism

E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration

(2020) Valentina C. Sladky et al.   DEVELOPMENTAL CELL

Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation

(2020) Valentina C. Sladky et al.   CELL DEATH AND DIFFERENTIATION

The cellular function of SCAP in metabolic signaling

(2020) Sun Hee Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26

(2020) Matteo Burigotto et al.   EMBO JOURNAL

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

(2019) Hsiao-Yen Ma et al.   JOURNAL OF HEPATOLOGY

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

(2018) Samir Softic et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Pathways Underlying Cholesterol Homeostasis

(2018) Milessa Silva Afonso et al.   Nutrients

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

(2018) Ju Youn Kim et al.   CELL

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver

(2017) Seonghwan Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER phospholipid composition modulates lipogenesis during feeding and in obesity

(2017) Xin Rong et al.   JOURNAL OF CLINICAL INVESTIGATION

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications

(2016) Sven M. Francque et al.   JOURNAL OF HEPATOLOGY

Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

(2016) Wei Shao (邵威) et al.   JOURNAL OF LIPID RESEARCH

Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis

(2016) Hai Wang et al.   Scientific Reports

Recent insights on the role of cholesterol in non-alcoholic fatty liver disease

(2015) Graciela Arguello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries

(2013) J. S. Jakobsen et al.   GENOME RESEARCH

Minireview: Endoplasmic Reticulum Stress: Control in Protein, Lipid, and Signal Homeostasis

(2013) József Mandl et al.   MOLECULAR ENDOCRINOLOGY

Insulin-dependent and -independent regulation of sterol regulatory element-binding protein-1c

(2013) Takashi Matsuzaka et al.   Journal of Diabetes Investigation

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Association Between Nonalcoholic Fatty Liver Disease and Risk for Hepatocellular Cancer, Based on Systematic Review

(2012) Donna L. White et al.   Clinical Gastroenterology and Hepatology

Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes

(2012) Manal F. Abdelmalek et al.   HEPATOLOGY

Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?

(2012) David van der Poorten et al.   HEPATOLOGY

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

(2011) Thanyarat Promlek et al.   MOLECULAR BIOLOGY OF THE CELL

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

(2009) Shinji Kamisuki et al.   CHEMISTRY & BIOLOGY

Degradation of Sterol Regulatory Element-binding Protein Precursor Requires the Endoplasmic Reticulum-associated Degradation Components Ubc7 and Hrd1 in Fission Yeast

(2009) Bridget T. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY