Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight

Chronic oral olanzapine treatment but not haloperidol decreases [3H] MK-801 binding in the rat brain Independent of dietary conditions

(2022) Leah Waldman et al.   NEUROSCIENCE LETTERS

Hypothalamic AMPK as a possible target for energy balance-related diseases

(2022) Miguel López   TRENDS IN PHARMACOLOGICAL SCIENCES

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

(2022) Diego Sáenz de Urturi et al.   Nature Communications

Safety of Intravenous Olanzapine Administration at a Tertiary Academic Medical Center

(2021) Nicholas F. Hunt et al.   ANNALS OF PHARMACOTHERAPY

Olanzapine induced reproductive toxicity in male rats

(2021) Cankız Mina Ardıç et al.   Scientific Reports

Ketamine's schizophrenia-like effects are prevented by targeting PTP1B

(2021) Zhaohong Qin et al.   NEUROBIOLOGY OF DISEASE

Activation of hypothalamic AMPK ameliorates metabolic complications of experimental arthritis

(2021) Patricia Seoane‐Collazo et al.   Arthritis & Rheumatology

Estrogen wars: The activity awakens

(2021) Miguel López   Cell Metabolism

The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice

(2021) Diana Grajales et al.   DIABETOLOGIA

Orally Induced Hyperthyroidism Regulates Hypothalamic AMP-Activated Protein Kinase

(2021) Valentina Capelli et al.   Nutrients

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

(2021) Nuria Pescador et al.   Redox Biology

Olanzapine increases AMPK-NPY orexigenic signaling by disrupting H1R-GHSR1a interaction in the hypothalamic neurons of mice

(2020) Xiaoqi Chen et al.   PSYCHONEUROENDOCRINOLOGY

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

(2020) Carmen Rubio et al.   Molecular Metabolism

Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty

(2020) Violeta Heras et al.   Cell Metabolism

Carnosic acid prevented olanzapine-induced metabolic disorders through AMPK activation

(2020) Bibi Marjan Razavi et al.   MOLECULAR BIOLOGY REPORTS

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

(2020) Carmen Escalona-Garrido et al.   Molecular Metabolism

An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake

(2020) Jia Zhang et al.   Nature Communications

Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk

(2020) Assel Sarsenbayeva et al.   PSYCHONEUROENDOCRINOLOGY

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases

(2019) Inmaculada García-Ruiz et al.   Redox Biology

Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain

(2019) Diana Grajales et al.   Cells

Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism

(2019) Assel Sarsenbayeva et al.   PSYCHONEUROENDOCRINOLOGY

Brown and beige fat: From molecules to physiology and pathophysiology

(2018) Stefania Carobbio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hypothalamic AMPK and energy balance

(2018) Miguel López   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies

(2018) Kyle J. Burghardt et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effects of chronic antipsychotic drug exposure on the expression of Translocator Protein and inflammatory markers in rat adipose tissue

(2018) Anita Calevro et al.   PSYCHONEUROENDOCRINOLOGY

Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia

(2018) Vincent Chin-Hung Chen et al.   PSYCHONEUROENDOCRINOLOGY

Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis

(2018) Águeda González-Rodríguez et al.   Molecular Metabolism

Lack of Ovarian Secretions Reverts the Anabolic Action of Olanzapine in Female Rats

(2017) Silje Skrede et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

(2017) Roksana M Pirzgalska et al.   NATURE MEDICINE

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes

(2016) Ester García-Casarrubios et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Metformin treatment of antipsychotic-induced dyslipidemia: an analysis of two randomized, placebo-controlled trials

(2016) R-R Wu et al.   MOLECULAR PSYCHIATRY

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

(2016) Miguel López et al.   Nature Reviews Endocrinology

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance

(2016) Luís Martins et al.   Cell Reports

Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders

(2016) So Hun Kim et al.   Diabetes & Metabolism Journal

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner

(2015) Águeda González-Rodríguez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

(2014) Shaun F. Morrison et al.   Cell Metabolism

Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

(2014) Pablo B. Martínez de Morentin et al.   Cell Metabolism

Long-term safety and efficacy of olanzapine long-acting injection in patients with schizophrenia or schizoaffective disorder

(2014) David P. McDonnell et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

The Antipsychotic Olanzapine Interacts with the Gut Microbiome to Cause Weight Gain in Mouse

(2014) Andrew P. Morgan et al.   PLoS One

Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats

(2014) Qingsheng Zhang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats

(2014) Meng He et al.   PSYCHONEUROENDOCRINOLOGY

Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor

(2014) Ryan C. Tsou et al.   Molecular Metabolism

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Antipsychotic polypharmacy in psychotic disorders: a critical review of neurobiology, efficacy, tolerability and cost effectiveness

(2013) Marc WH Lochmann van Bennekom et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis

(2013) Stefan Leucht et al.   LANCET

Olanzapine-Induced Hyperglycemia: Possible Involvement of Histaminergic, Dopaminergic and Adrenergic Functions in the Central Nervous System

(2013) Megumi Ikegami et al.   NEUROENDOCRINOLOGY

Haloperidol and olanzapine mediate metabolic abnormalities through different molecular pathways

(2013) V Mondelli et al.   Translational Psychiatry

Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat

(2013) K J Davey et al.   Translational Psychiatry

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Intracerebroventricular Administration of Metformin Inhibits Ghrelin-Induced Hypothalamic AMP-Kinase Signalling and Food Intake

(2012) Darko Stevanovic et al.   NEUROENDOCRINOLOGY

Neuronal circuits involving neuropeptide Y in hypothalamic arcuate nucleus-mediated feeding regulation

(2012) Haruaki Kageyama et al.   NEUROPEPTIDES

Intracerebroventricular Injection of Metformin Induces Anorexia in Rats

(2012) Chang Koo Lee et al.   Diabetes & Metabolism Journal

Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging

(2011) Águeda González-Rodríguez et al.   AGING CELL

The acute effects of olanzapine on ghrelin secretion, CCK sensitivity, meal size, locomotor activity and body temperature

(2011) E M van der Zwaal et al.   INTERNATIONAL JOURNAL OF OBESITY

Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation

(2011) Johan Fernø et al.   PLoS One

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

Increased Food Intake and Energy Expenditure Following Administration of Olanzapine to Healthy Men

(2010) Robert J. Fountaine et al.   Obesity

A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal model

(2010) Heidi N. Boyda et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli

(2009) Soledad Miranda et al.   CELLULAR SIGNALLING

Short-term treatment with olanzapine does not modulate gut hormone secretion: olanzapine disintegrating versus standard tablets

(2009) Solrun Vidarsdottir et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

(2009) Maria Cristina Zingaretti et al.   FASEB JOURNAL

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

(2008) M. Delibegovic et al.   DIABETES

The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: Comparison with aripiprazole, ziprasidone, bifeprunox and F15063

(2008) Marie-Bernadette Assié et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Negative effects of chronic oral chlorpromazine and olanzapine treatment on the performance of tasks designed to assess spatial learning and working memory in rats

(2008) A.V. Terry et al.   NEUROSCIENCE

Differential Effects of Various Typical and Atypical Antipsychotics on Plasma Glucose and Insulin Levels in the Mouse: Evidence for the Involvement of Sympathetic Regulation

(2008) Y. E. Savoy et al.   SCHIZOPHRENIA BULLETIN