Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress

Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling

(2015) Xueyuan Bi et al.   CELL CYCLE

Naltrexone Extended-Release Plus Bupropion Extended-Release for Treatment of Obesity

(2015) Susan Z. Yanovski et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hypothalamic control of hepatic lipid metabolism via the autonomic nervous system

(2014) Eveline Bruinstroop et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons

(2014) Gregory S. Parks et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice

(2014) Daniela C. Kroy et al.   JOURNAL OF HEPATOLOGY

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

(2014) Cristina Contreras et al.   Cell Reports

Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

(2014) Ana I Domingos et al.   eLife

The autonomic nervous system regulates postprandial hepatic lipid metabolism

(2013) Eveline Bruinstroop et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mice lacking δ-opioid receptors resist the development of diet-induced obesity

(2012) Traci A. Czyzyk et al.   FASEB JOURNAL

Central Melanin-Concentrating Hormone Influences Liver and Adipose Metabolism Via Specific Hypothalamic Nuclei and Efferent Autonomic/JNK1 Pathways

(2012) Monica Imbernon et al.   GASTROENTEROLOGY

Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus

(2012) Melissa J.S. Chee et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Involvement of the opioid system in the orexigenic and hedonic effects of melanin-concentrating hormone

(2011) Carlos Andres Lopez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice

(2010) Yan Wang et al.   GUT

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically

(2010) S. Stanley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia–reperfusion

(2010) I Ben Mosbah et al.   Cell Death & Disease

κ-Opioid receptors control the metabolic response to a high-energy diet in mice

(2009) Traci A. Czyzyk et al.   FASEB JOURNAL

Direct Control of Peripheral Lipid Deposition by CNS GLP-1 Receptor Signaling Is Mediated by the Sympathetic Nervous System and Blunted in Diet-Induced Obesity

(2009) R. Nogueiras et al.   JOURNAL OF NEUROSCIENCE

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION

Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice

(2008) Makoto Ito et al.   JOURNAL OF ENDOCRINOLOGY

MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes

(2008) Claire Z. Larter et al.   JOURNAL OF HEPATOLOGY

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

(2008) Mary E. Rinella et al.   JOURNAL OF LIPID RESEARCH