Hesperetin derivative 2a inhibits lipopolysaccharide-induced acute liver injury in mice via downregulation of circDcbld2

A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR

(2023) Runjie Song et al.   Molecular Cancer

CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export

(2023) Xiaopeng Yu et al.   Cell Death & Disease

Clinical delivery of circular RNA: Lessons learned from RNA drug development

(2023) Tiana Loan Young et al.   ADVANCED DRUG DELIVERY REVIEWS

Proangiogenic role of circRNA‐007371 in liver fibrosis

(2023) Chong Zhao et al.   CELL PROLIFERATION

Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

(2023) Zongqiang Hu et al.   Molecular Cancer

Global epidemiology of cirrhosis — aetiology, trends and predictions

(2023) Daniel Q. Huang et al.   Nature Reviews Gastroenterology & Hepatology

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(2022) Sema Misir et al.   CELL DEATH AND DIFFERENTIATION

The function and regulation network mechanism of circRNA in liver diseases

(2022) Panpan Wang et al.   Cancer Cell International

XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury

(2022) Zheng Liu et al.   Redox Biology

Circular RNA as a Novel Biomarker and Therapeutic Target for HCC

(2022) Hongwu Meng et al.   Cells

Spotlight on liver macrophages for halting liver disease progression and injury

(2022) Amit Khurana et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions

(2022) Yuan-Bin Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Management of liver diseases: Current perspectives

(2022) Gautam Ray   WORLD JOURNAL OF GASTROENTEROLOGY

CircRNA GFRA1 promotes hepatocellular carcinoma progression by modulating the miR-498/NAP1L3 axis

(2021) Shuai Lv et al.   Scientific Reports

Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR‐149‐5p/TGF‐β2 axis

(2021) Sai Zhu et al.   FASEB JOURNAL

Liver Injury and the Macrophage Issue: Molecular and Mechanistic Facts and Their Clinical Relevance

(2021) Siyer Roohani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hesperetin derivative-16 attenuates CCl4-induced inflammation and liver fibrosis by activating AMPK/SIRT3 pathway

(2021) Juan-Juan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis

(2021) Jian Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the hsa-miR-1291/LEFTY2 Axis

(2021) Ya-Ru Yang et al.   Frontiers in Pharmacology

Macrophage Polarization and Its Role in Liver Disease

(2021) Cheng Wang et al.   Frontiers in Immunology

Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: Perspectives for scleroderma-associated interstitial lung disease

(2020) Alain Lescoat et al.   BIOCHEMICAL PHARMACOLOGY

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

(2020) Yankai Wen et al.   Cellular & Molecular Immunology

Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway

(2020) Si-wei Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

(2019) Tahir Muhammad et al.   Nutrients

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Hesperetin derivative attenuates CCl4-induced hepatic fibrosis and inflammation by Gli-1-dependent mechanisms

(2019) Xin Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Repression of interferon β-regulated cytokines by the JAK1/2 inhibitor ruxolitinib in inflammatory human macrophages

(2018) Marie Febvre-James et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives

(2018) Ai-Ling Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Macrophage Phenotype in Liver Injury and Repair

(2017) Y.-Y. Sun et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl 4 -induced acute liver injury and LPS-treated RAW264.7 cells

(2017) Xin Chen et al.   TOXICOLOGY LETTERS

Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases

(2015) Ali Roohbakhsh et al.   LIFE SCIENCES

The novel Janus kinase inhibitor ruxolitinib confers protection against carbon tetrachloride-induced hepatotoxicity via multiple mechanisms

(2014) Sara H. Hazem et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice

(2014) Hiroko Tsutsui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

(2014) Hamideh Parhiz et al.   PHYTOTHERAPY RESEARCH