Regulation of Nur77-TLR4/MyD88 signaling pathway is required for Ginsenoside Rc ameliorates hepatic fibrosis regression by deactivating hepatic stellate cells

Nur77 Prevents Osteoporosis by Inhibiting the NF‐κB Signalling Pathway and Osteoclast Differentiation

(2022) Huanlian Tian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease

(2022) Zhisen Pan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ginsenoside Rc attenuates DSS-induced ulcerative colitis, intestinal inflammatory, and barrier function by activating the farnesoid X receptor

(2022) Kaijia Tang et al.   Frontiers in Pharmacology

Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress

(2022) Yadi Zhong et al.   Frontiers in Pharmacology

The role of hepatic microenvironment in hepatic fibrosis development

(2022) Ying Meng et al.   ANNALS OF MEDICINE

Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis

(2021) Sai-nan Chen et al.   ACTA PHARMACOLOGICA SINICA

Crosstalk between hepatic stellate cells and surrounding cells in hepatic fibrosis

(2021) Fangming Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hepatic Stellate Cell: A Double-Edged Sword in the Liver

(2021) N. Luo et al.   PHYSIOLOGICAL RESEARCH

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

(2021) Shuang-zhou Peng et al.   Nature Communications

Insight Into TLR4-Mediated Immunomodulation in Normal Pregnancy and Related Disorders

(2020) Priyanka Firmal et al.   Frontiers in Immunology

Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy

(2020) Desong Kong et al.   Redox Biology

20S-Protopanaxatriol Ameliorates Hepatic Fibrosis, Potentially Involving FXR-Mediated Inflammatory Signaling Cascades

(2020) Jian Song et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway

(2020) Xiangxiang Liu et al.   Cell Death & Disease

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

(2020) Peng Zhang et al.   Frontiers in Immunology

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

(2020) Anna Ciesielska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

(2019) Ping Zhou et al.   Cells

Panax ginseng Pharmacopuncture: Current Status of the Research and Future Challenges

(2019) In-Seon Lee et al.   Biomolecules

Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity

(2018) Marie Liebmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Orphan nuclear receptor Nur77 inhibits poly (I:C)-triggered acute liver inflammation by inducing the ubiquitin-editing enzyme A20

(2017) Xiu-Ming Li et al.   Oncotarget

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Accelerated Partial Hepatectomy–Induced Liver Cell Proliferation Is Associated with Liver Injury in Nur77 Knockout Mice

(2014) Ying Hu et al.   AMERICAN JOURNAL OF PATHOLOGY

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

(2009) Lily C. Chao et al.   DIABETES