Quantitative Translation of Substrate Intrinsic Clearance from Recombinant CYP1A1 to Humans

In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes

(2023) David Tess et al.   AAPS Journal

Drug disposition protein quantification in matched human jejunum and liver from donors with obesity

(2022) Christine Wegler et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In Vitro - in Vivo Extrapolation of Hepatic Clearance in Preclinical Species

(2022) David A. Tess et al.   PHARMACEUTICAL RESEARCH

Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats

(2021) Marcos Antonio Ferreira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global Analysis of Models for Predicting Human Absorption: QSAR, In Vitro, and Preclinical Models

(2021) Edward Price et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery

(2020) Mari Davies et al.   DRUG METABOLISM AND DISPOSITION

Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes

(2020) Christopher Keefer et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Drug–Drug Interactions Involving Intestinal and Hepatic CYP1A Enzymes

(2020) Florian Klomp et al.   Pharmaceutics

Highly Variable Expression of CYP1A1 in Human Liver and Impact on Pharmacokinetics of Riociguat and Granisetron in Humans

(2019) Dieter Lang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Physicochemical Properties, Biotransformation, and Transport Pathways of Established and Newly Approved Medications: A Systematic Review of the Top 200 Most Prescribed Drugs vs. the FDA-Approved Drugs Between 2005 and 2016

(2019) Anitha Saravanakumar et al.   CLINICAL PHARMACOKINETICS

Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate

(2019) Aaron G. Bart et al.   DRUG METABOLISM AND DISPOSITION

Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats

(2018) Mahua Sarkar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date

(2017) et al.   MOLECULES

Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

(2016) Rebeca Santes-Palacios et al.   Biomed Research International

Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

(2016) Lars P. H. Andersen et al.   BMC Pharmacology & Toxicology

Pharmacokinetic Interaction of Riociguat with Ketoconazole, Clarithromycin, and Midazolam

(2016) Corina Becker et al.   Pulmonary Circulation

Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator Riociguat in Healthy Young Chinese Male Non-Smokers and Smokers: Results of a Randomized, Double-Blind, Placebo-Controlled Study

(2015) Xia Zhao et al.   CLINICAL PHARMACOKINETICS

Expression of CYP1A1 and GSTP1 in Human Brain Tumor Tissues in Pakistan

(2014) Mussarat Wahid et al.   Asian Pacific Journal of Cancer Prevention

Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism

(2013) Agnes A. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures andin silicomodeling

(2012) Dong Dong et al.   DRUG METABOLISM REVIEWS

Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds

(2010) A.-K. Sohlenius-Sternbeck et al.   XENOBIOTICA