Physicochemical Properties, Biotransformation, and Transport Pathways of Established and Newly Approved Medications: A Systematic Review of the Top 200 Most Prescribed Drugs vs. the FDA-Approved Drugs Between 2005 and 2016

Associations of Drug Lipophilicity and Extent of Metabolism with Drug-Induced Liver Injury

(2017) Kristin McEuen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Molecular inflation, attrition and the rule of five

(2016) Paul D. Leeson   ADVANCED DRUG DELIVERY REVIEWS

Non-cytochrome P450-mediated bioactivation and its toxicological relevance

(2016) Jinping Gan et al.   DRUG METABOLISM REVIEWS

A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development

(2015) Shingo Oda et al.   Drug Metabolism and Pharmacokinetics

PubChem Substance and Compound databases

(2015) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans

(2014) Chelsea M. Hosey et al.   AAPS Journal

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

(2014) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism - a prospective, randomized, controlled study

(2013) Si-Yang Chen et al.   CLINICAL TRANSPLANTATION

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orphans in the Human Cytochrome P450 Superfamily: Approaches to Discovering Functions and Relevance in Pharmacology

(2011) F. P. Guengerich et al.   PHARMACOLOGICAL REVIEWS

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

(2010) David C. Pryde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Prediction of Biliary Excretion in Rats and Humans Using Molecular Weight and Quantitative Structure–Pharmacokinetic Relationships

(2009) Xinning Yang et al.   AAPS Journal

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney

(2009) Hiroyuki Kusuhara et al.   Drug Metabolism and Pharmacokinetics

Physicochemical drug properties associated within vivotoxicological outcomes: a review

(2009) David A Price et al.   Expert Opinion on Drug Metabolism & Toxicology

The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy

(2009) S P R Romaine et al.   PHARMACOGENOMICS JOURNAL