In Vitro - in Vivo Extrapolation of Hepatic Clearance in Preclinical Species

Effects of Low Temperature on Blood‐to‐Plasma Ratio Measurement

(2021) Jonathan J. Novak et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization

(2021) Jasleen K. Sodhi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dose Predictions for Drug Design

(2020) Tristan S. Maurer et al.   JOURNAL OF MEDICINAL CHEMISTRY

A physiologically-based in-silico tool to assess the risk of drug-related crystalluria

(2020) zhenhong li et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Critical Role of Passive Permeability in Designing Successful Drugs

(2020) Li Di et al.   ChemMedChem

Investigating the Theoretical Basis for In Vitro–In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways

(2020) Leslie Z. Benet et al.   AAPS Journal

Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs

(2020) David A. Tess et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes

(2020) Christopher Keefer et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Use of segregated hepatocyte scaling factors and cross-species relationship to resolve clearance-dependency in prediction of human hepatic clearance

(2019) David Hallifax et al.   DRUG METABOLISM AND DISPOSITION

A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes

(2019) Keith A. Riccardi et al.   DRUG METABOLISM AND DISPOSITION

In Vitro–In Vivo Extrapolation of Key Transporter Activity at the Blood–Brain Barrier

(2019) Patrick E. Trapa et al.   DRUG METABOLISM AND DISPOSITION

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

(2018) Tom De Bruyn et al.   DRUG METABOLISM AND DISPOSITION

Clearance in Drug Design

(2018) Dennis A. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relevance of Half-Life in Drug Design

(2017) Dennis A. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

(2017) Emi Kimoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration

(2016) Patrick E. Trapa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Volume of Distribution in Drug Design

(2015) Dennis A. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

(2015) Manthena V. Varma et al.   PHARMACEUTICAL RESEARCH

The role of drug metabolizing enzymes in clearance

(2014) Li Di   Expert Opinion on Drug Metabolism & Toxicology

A “middle-out” approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling

(2014) Rui Li et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Interpretable, Probability-Based Confidence Metric for Continuous Quantitative Structure–Activity Relationship Models

(2013) Christopher E. Keefer et al.   Journal of Chemical Information and Modeling

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

(2012) Li Di et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs

(2012) David Hallifax et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Prediction of Human Renal Clearance from Preclinical Species for a Diverse Set of Drugs That Exhibit Both Active Secretion and Net Reabsorption

(2011) S. W. Paine et al.   DRUG METABOLISM AND DISPOSITION

Development of a new permeability assay using low‐efflux MDCKII cells

(2011) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

(2010) David Hallifax et al.   PHARMACEUTICAL RESEARCH

Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and pKa to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists

(2009) T. Hay et al.   DRUG METABOLISM AND DISPOSITION

Tautomer Enumeration and Stability Prediction for Virtual Screening on Large Chemical Databases

(2009) Francesca Milletti et al.   Journal of Chemical Information and Modeling

Measurement of Dissociation Constants (pKa Values) of Organic Compounds by Multiplexed Capillary Electrophoresis Using Aqueous and Cosolvent Buffers**Advanced Analytical Technologies, Inc. (Formerly CombiSep), 2711 South Loop Drive, Suite 4200, Ames, IA 50010.

(2008) Marina Shalaeva et al.   JOURNAL OF PHARMACEUTICAL SCIENCES