Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade

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Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity

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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

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A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspective

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Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

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The journey of tumor-infiltrating lymphocytes as a biomarker in breast cancer: clinical utility in an era of checkpoint inhibition

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NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

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Pembrolizumab for Early Triple-Negative Breast Cancer

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Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer

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A multi-batch design to deliver robust estimates of efficacy and reduce animal use – a syngeneic tumour case study

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Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

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Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

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Tumor-infiltrating lymphocytes and CD8+ T cells predict survival of triple-negative breast cancer

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CD49b, CD87, and CD95 Are Markers for Activated Cancer-Associated Fibroblasts Whereas CD39 Marks Quiescent Normal Fibroblasts in Murine Tumor Models

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Comprehensive Benchmarking and Integration of Tumor Microenvironment Cell Estimation Methods

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Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

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Checkpoint blockade in the treatment of breast cancer: current status and future directions

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Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

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Understanding the tumor immune microenvironment (TIME) for effective therapy

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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

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Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

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FAP delineates heterogeneous and functionally divergent stromal cells in immune-excluded breast tumors

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Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

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IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

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Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

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Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

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Comprehensive molecular portraits of human breast tumours

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