New Xanthone Derivatives as Potent G-Quadruplex Binders for Developing Anti-Cancer Therapeutics

R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures

(2022) Anita Donlic et al.   ACS Chemical Biology

Chemical Information and Computational Modeling of Targeting Hybrid Nucleic Acid Structures of PIM1 Sequences by Synthetic Pyrrole-Imidazole Carboxamide Drugs

(2022) Soma Roy et al.   Journal of Chemical Information and Modeling

Deciphering the Binding Insights of Novel Disubstituted Anthraquinone Derivatives with G‐Quadruplex DNA to Exhibit Selective Cancer Cell Cytotoxicity

(2022) Soma Roy et al.   ChemMedChem

Design and Synthesis of Xanthone Analogues Conjugated with Aza‐aromatic Substituents as Promising G‐Quadruplex Stabilizing Ligands and their Selective Cancer Cell Cytotoxic Action

(2022) Soma Roy et al.   CHEMBIOCHEM

Biological relevance and therapeutic potential of G-quadruplex structures in the human noncoding transcriptome

(2021) Martina Tassinari et al.   NUCLEIC ACIDS RESEARCH

Theoretical Insight into the Library Screening Approach for Binding of Intermolecular G-Quadruplex RNA and Small Molecules through Docking and Molecular Dynamics Simulation Studies

(2021) Soma Roy et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Synthesis, Characterization and DNA-Binding Affinity of a New Zinc(II) Bis(5-methoxy-indol-3-yl)propane-1,3-dione Complex

(2021) Luca Scapinello et al.   Pharmaceuticals

G4LDB 2.2: a database for discovering and studying G-quadruplex and i-Motif ligands

(2021) Yu-Huan Wang et al.   NUCLEIC ACIDS RESEARCH

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specific stabilization of promoter G-Quadruplex DNA by 2,6-disubstituted amidoanthracene-9,10-dione based dimeric distamycin analogues and their selective cancer cell cytotoxicity

(2020) Soma Roy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cationic porphyrins with large side arm substituents as resonance light scattering ratiometric probes for specific recognition of nucleic acid G-quadruplexes

(2019) Li-Ming Zhang et al.   NUCLEIC ACIDS RESEARCH

R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes

(2019) Brittany S. Morgan et al.   ACS Chemical Biology

Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazole‒carbazole ligands

(2018) Mangesh H. Kaulage et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phenanthroline polyazamacrocycles as G-quadruplex DNA binders

(2018) Josué Carvalho et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity

(2017) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation

(2017) Giulia Miglietta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents

(2017) Xing Chen et al.   MedChemComm

Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions

(2017) Jagannath Jana et al.   Scientific Reports

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

Specific Stabilization of c-MYC and c-KIT G-Quadruplex DNA Structures by Indolylmethyleneindanone Scaffolds

(2016) K. V. Diveshkumar et al.   BIOCHEMISTRY

Synthesis and biological evaluation of disubstituted amidoxanthones as potential telomeric G-quadruplex DNA-binding and apoptosis-inducing agents

(2016) Rui Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Oligopyrrole Carboxamide based Nickel(II) and Palladium(II) Salens, Their Targeting of Human G-Quadruplex DNA, and Selective Cancer Cell Toxicity

(2016) Asfa Ali et al.   Chemistry-An Asian Journal

A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA

(2016) Yousuke Katsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent

(2016) Soma Mondal et al.   Molecular BioSystems

Structural insights into conformational stability of both wild-type and mutant EZH2 receptor

(2016) Imlimaong Aier et al.   Scientific Reports

Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure–Activity Relationship Study of N6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson’s Disease

(2015) Banibrata Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA

(2015) Jie Dai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nonpeptidic Amphiphilic Xanthone Derivatives: Structure–Activity Relationship and Membrane-Targeting Properties

(2015) Jun-Jie Koh et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies

(2015) Marco Deiana et al.   PLoS One

Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents

(2014) Xiang Fei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Existence and consequences of G-quadruplex structures in DNA

(2014) Pierre Murat et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Design and Synthesis of New Benzimidazole–Carbazole Conjugates for the Stabilization of Human Telomeric DNA, Telomerase Inhibition, and Their Selective Action on Cancer Cells

(2014) Basudeb Maji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Novel Bisbenzimidazoles as Escherichia coli Topoisomerase IA Inhibitors and Potential Antibacterial Agents

(2014) Hemlata Nimesh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prenylated Benzoylphloroglucinols and Xanthones from the Leaves of Garcinia oblongifolia with Antienteroviral Activity

(2014) Hong Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Ligand 5,10,15,20-Tetra(N-methyl-4-pyridyl)porphine (TMPyP4) Prefers the Parallel Propeller-Type Human Telomeric G-Quadruplex DNA over Its Other Polymorphs

(2014) Asfa Ali et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage

(2014) Marco Franceschin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Antitumor Activity and DNA-Binding Investigations of Isoeuxanthone and Its Piperidinyl Derivative

(2013) Huifang Wang et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Drug–DNA interactions and their study by UV–Visible, fluorescence spectroscopies and cyclic voltametry

(2013) Muhammad Sirajuddin et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Xanthene and Xanthone Derivatives as G-Quadruplex Stabilizing Ligands

(2013) Alessandro Altieri et al.   MOLECULES

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

Comparison of MM/GBSA calculations based on explicit and implicit solvent simulations

(2013) Frithjof Godschalk et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Dimeric 1,3-Phenylene-bis(piperazinyl benzimidazole)s: Synthesis and Structure–Activity Investigations on their Binding with Human Telomeric G-Quadruplex DNA and Telomerase Inhibition Properties

(2012) Akash K Jain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stabilization and Structural Alteration of the G-Quadruplex DNA Made from the Human Telomeric Repeat Mediated by Tröger’s Base Based Novel Benzimidazole Derivatives

(2012) Ananya Paul et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Interaction of G-Quadruplexes with Nonintercalating Duplex-DNA Minor Groove Binding Ligands

(2011) Akash K. Jain et al.   BIOCONJUGATE CHEMISTRY

The application of DNA and RNA G-quadruplexes to therapeutic medicines

(2011) Gavin W. Collie et al.   CHEMICAL SOCIETY REVIEWS

Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents

(2011) Ting Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes

(2011) Nancy H. Campbell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Symmetrical Bisbenzimidazoles with Benzenediyl Spacer: The Role of the Shape of the Ligand on the Stabilization and Structural Alterations in Telomeric G-Quadruplex DNA and Telomerase Inhibition

(2010) Santanu Bhattacharya et al.   BIOCONJUGATE CHEMISTRY

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

Synthesis and Evaluation of a Novel Class of G-Quadruplex-Stabilizing Small Molecules Based on the 1,3-Phenylene-Bis(piperazinyl benzimidazole) System

(2009) Akash K. Jain et al.   BIOCHEMISTRY

Synthesis and Spectroscopic Properties of Rosamines with Cyclic Amine Substituents

(2008) Liangxing Wu et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS