Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions

Plant Alkaloid Chelerythrine Induced Aggregation of Human Telomere Sequence—A Unique Mode of Association between a Small Molecule and a Quadruplex

(2015) Saptaparni Ghosh et al.   BIOCHEMISTRY

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

(2015) João Lavrado et al.   Scientific Reports

Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives

(2014) Yue Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Small-molecule quadruplex-targeted drug discovery

(2014) Stephan A. Ohnmacht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Relative stability of G-quadruplex structures: Interactions between the human Bcl2 promoter region and derivatives of carbazole and diphenylamine

(2014) Sheh-Yi Sheu et al.   BIOPOLYMERS

G-Quadruplex Structures and Their Interaction Diversity with Ligands

(2014) Sulin Zhang et al.   ChemMedChem

Sequence context induced antimicrobial activity: insight into lipopolysaccharide permeabilization

(2014) Anirban Ghosh et al.   Molecular BioSystems

Mechanistic insight into ligand binding to G-quadruplex DNA

(2014) Francesco Saverio Di Leva et al.   NUCLEIC ACIDS RESEARCH

Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes

(2014) Li-Ping Bai et al.   Scientific Reports

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3

(2013) Wan Jun Chung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular basis of recognition of quadruplexes human telomere and c-myc promoter by the putative anticancer agent sanguinarine

(2013) Saptaparni Ghosh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Roles for KRAS in Pancreatic Tumor Development and Progression

(2013) Marina Pasca di Magliano et al.   GASTROENTEROLOGY

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

Human cathelicidin peptide LL37 binds telomeric G-quadruplex

(2013) Jagannath Jana et al.   Molecular BioSystems

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

Use of a Small Peptide Fragment as an Inhibitor of Insulin Fibrillation Process: A Study by High and Low Resolution Spectroscopy

(2013) Victor Banerjee et al.   PLoS One

Spectroscopic probing of recognition of the G-quadruplex in c-kit promoter by small-molecule natural products

(2012) Xiaojie Cui et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Methods for investigating G-quadruplex DNA/ligand interactions

(2011) Pierre Murat et al.   CHEMICAL SOCIETY REVIEWS

Selective G-quadruplex DNA Stabilizing Agents Based on Bisquinolinium and Bispyridinium Derivatives of 1,8-Naphthyridine

(2011) V. Dhamodharan et al.   JOURNAL OF ORGANIC CHEMISTRY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

New Strategies for Treatment of KRAS Mutant Metastatic Colorectal Cancer

(2010) H. Prenen et al.   CLINICAL CANCER RESEARCH

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

Applications of Isothermal Titration Calorimetry in Biophysical Studies of G-quadruplexes

(2009) Bruno Pagano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells

(2009) Anjali Verma et al.   NUCLEIC ACIDS RESEARCH

Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers

(2008) Satoru Kyo et al.   CANCER SCIENCE

Binding of berberine to human telomeric quadruplex - spectroscopic, calorimetric and molecular modeling studies

(2008) Amit Arora et al.   FEBS Journal

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

(2008) K. Guo et al.   NUCLEIC ACIDS RESEARCH

Stability and kinetics of G-quadruplex structures

(2008) A. N. Lane et al.   NUCLEIC ACIDS RESEARCH