CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease

Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced Parkinson's disease model in rats

(2022) Khalid A. El-Saiy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson’s Disease and Lewy Body Dementia

(2022) Chang-ki Oh et al.   JOURNAL OF NEUROSCIENCE

Stem Cell Therapy: From Idea to Clinical Practice

(2022) Mohammad Mousaei Ghasroldasht et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bone Marrow-Derived Mesenchymal Stem Cell-Derived Exosomes Containing Gli1 Alleviate Microglial Activation and Neuronal Apoptosis In Vitro and in a Mouse Parkinson Disease Model by Direct Inhibition of Sp1 Signaling

(2022) Yang Cai et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CRISPR/Cas9-Mediated Disruption of ZNF543 Gene: An Approach Toward Discovering Its Relation to TRIM28 Gene in Parkinson’s Disease

(2022) Mohammad Hashemabadi et al.   MOLECULAR BIOTECHNOLOGY

Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing

(2022) Carol X.-Q. Chen et al.   Stem Cell Research

Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson’s disease mice

(2022) Yea-Hyun Leem et al.   Scientific Reports

Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease

(2021) Subhrangshu Guhathakurta et al.   EMBO Molecular Medicine

Generation of PARP1 gene knockout human embryonic stem cell line using CRISPR/Cas9

(2021) Yuhang Li et al.   Stem Cell Research

Parkinson's disease

(2021) Bastiaan R Bloem et al.   LANCET

microRNA-106b-containing extracellular vesicles affect autophagy of neurons by regulating CDKN2B in Parkinson’s disease

(2021) Xue Bai et al.   NEUROSCIENCE LETTERS

7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson’s disease

(2021) Li Zuo et al.   Cell Death Discovery

iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates

(2020) A. H. Laperle et al.   NATURE MEDICINE

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

(2020) Tim Ahfeldt et al.   Stem Cell Reports

Generation of two LRRK2 homozygous knockout human induced pluripotent stem cell lines using CRISPR/Cas9

(2020) Shuhan Chen et al.   Stem Cell Research

Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease

(2020) Deqiang Han et al.   Frontiers in Cellular Neuroscience

Exosomes derived from mesenchymal stem cells repair a Parkinson’s disease model by inducing autophagy

(2020) Hong-Xu Chen et al.   Cell Death & Disease

Gene therapy for Alzheimer’s disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation

(2020) Ana Griciuc et al.   HUMAN MOLECULAR GENETICS

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanistic Interplay between Autophagy and Apoptotic Signaling in Endosulfan-induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity

(2019) Chunjuan Song et al.   TOXICOLOGICAL SCIENCES

Intranasal administration of endometrial mesenchymal stem cells as a suitable approach for Parkinson’s disease therapy

(2019) Saeid Bagheri-Mohammadi et al.   MOLECULAR BIOLOGY REPORTS

Dysfunction of Cellular Proteostasis in Parkinson’s Disease

(2019) Šárka Lehtonen et al.   Frontiers in Neuroscience

CRISPR System: A High-throughput Toolbox for Research and Treatment of Parkinson’s Disease

(2019) Fatemeh Safari et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

CRISPR/Cas System: Recent Advances and Future Prospects for Genome Editing

(2019) Hakim Manghwar et al.   TRENDS IN PLANT SCIENCE

Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B- mediated Parkinson's disease

(2018) Yujing Gao et al.   Stem Cell Research

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

(2018) Ryosuke Kojima et al.   Nature Communications

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

(2018) David C. Schöndorf et al.   Cell Reports

Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction

(2018) Yukari Suda et al.   Molecular Brain

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes

(2018) Matthew Neal et al.   GLIA

CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in α-Synuclein Causing Parkinson’s Disease

(2018) Xiang-Xing Zhu et al.   Scientific Reports

Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene

(2018) Yixi Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson’s disease

(2017) Cynthia Sandor et al.   HUMAN MOLECULAR GENETICS

CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation

(2017) Hyojung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

(2017) Christoph Potting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A homozygous Keap1-knockout human embryonic stem cell line generated using CRISPR/Cas9 mediates gene targeting

(2017) So-Jung Kim et al.   Stem Cell Research

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons

(2017) Xiaobing Qing et al.   Stem Cell Research

CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects

(2017) Zhao Zhang et al.   Molecular Therapy-Nucleic Acids

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

(2017) Jonathan Arias-Fuenzalida et al.   Stem Cell Reports

A novel tool for monitoring endogenous alpha-synuclein transcription by NanoLuciferase tag insertion at the 3′end using CRISPR-Cas9 genome editing technique

(2017) Sambuddha Basu et al.   Scientific Reports

Midnolin is a novel regulator of parkin expression and is associated with Parkinson’s Disease

(2017) Yutaro Obara et al.   Scientific Reports

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

(2017) Walther Haenseler et al.   Scientific Reports

Therapeutic effects of baicalein on rotenone-induced Parkinson’s disease through protecting mitochondrial function and biogenesis

(2017) Xue Zhang et al.   Scientific Reports

CRISPR/Cas9 in Genome Editing and Beyond

(2016) Haifeng Wang et al.   Annual Review of Biochemistry

Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications

(2016) Andriy Didovyk et al.   CURRENT OPINION IN BIOTECHNOLOGY

Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics

(2016) Seong Soo An et al.   International Journal of Nanomedicine

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges

(2016) Bin Xiao et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Multifactorial theory applied to the neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson’s disease

(2016) Xiao-feng Zhang et al.   LABORATORY INVESTIGATION

Fasudil Enhances Therapeutic Efficacy of Neural Stem Cells in the Mouse Model of MPTP-Induced Parkinson’s Disease

(2016) Yan-Hua Li et al.   MOLECULAR NEUROBIOLOGY

329. Using CRISPR/Cas9 as a Therapeutic Approach for Leber Congenital Amaurosis 10 (LCA10)

(2016) Guoxiang Ruan et al.   MOLECULAR THERAPY

Evolving basic, pathological and clinical concepts in PD

(2016) Lorraine V. Kalia et al.   Nature Reviews Neurology

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

(2016) Richard Gordon et al.   NEUROBIOLOGY OF DISEASE

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Genome-Editing Technologies: Principles and Applications

(2016) Thomas Gaj et al.   Cold Spring Harbor Perspectives in Biology

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

(2016) Richard Gordon et al.   Nature Communications

Finding the ‘Guilty’ Gene Variant of Sporadic Parkinson’s Disease Via CRISPR/Cas9

(2016) Shenzhao Lu et al.   Neuroscience Bulletin

One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

(2016) Xianlong Wang et al.   Scientific Reports

Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing

(2016) Yuichiro Miyaoka et al.   Scientific Reports

Regenerative Therapy and Immune Modulation Using Umbilical Cord Blood–Derived Cells

(2015) Pauline Damien et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Human mesenchymal stem cells - current trends and future prospective

(2015) Imran Ullah et al.   BIOSCIENCE REPORTS

Crystal Structure of Staphylococcus aureus Cas9

(2015) Hiroshi Nishimasu et al.   CELL

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

A Cas9-guide RNA complex preorganized for target DNA recognition

(2015) F. Jiang et al.   SCIENCE

Modeling Disease In Vivo With CRISPR/Cas9

(2015) Lukas E. Dow   TRENDS IN MOLECULAR MEDICINE

Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson’s disease

(2015) Mariana Acquarone et al.   Frontiers in Cellular Neuroscience

Potential of Neural Stem Cell-Based Therapy for Parkinson’s Disease

(2015) Chung-Hsing Chou et al.   Parkinsons Disease

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

(2014) Hiroshi Nishimasu et al.   CELL

Lenti-GDNF Gene Therapy Protects Against Alzheimer's Disease-Like Neuropathology in 3xTg-AD Mice and MC65 Cells

(2014) Susana Revilla et al.   CNS Neuroscience & Therapeutics

Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9

(2014) Rajat M. Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

(2014) Stéphane Palfi et al.   LANCET

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

(2014) Carolin Anders et al.   NATURE

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

(2014) M. Jinek et al.   SCIENCE

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Introduction to Stem Cell Therapy

(2013) Jesse K. Biehl et al.   Journal of Cardiovascular Nursing

Glutathion-S-Transferases (GSTs) and Parkinson’s disease in a MPTP-induced C57BL/6 mouse model

(2013) Elcin Ozdamar et al.   Molecular Neurodegeneration

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

(2013) Prashant Mali et al.   NATURE BIOTECHNOLOGY

The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems

(2013) Krzysztof Chylinski et al.   RNA Biology

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models

(2012) Nian Xiong et al.   CRITICAL REVIEWS IN TOXICOLOGY

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation

(2012) Richard Gordon et al.   Journal of Neuroinflammation

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

(2012) Beomsue Kim et al.   PLoS One

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

(2012) Agnete Kirkeby et al.   Cell Reports

Molecular pathways in sporadic PD

(2011) Enza Maria Valente et al.   PARKINSONISM & RELATED DISORDERS

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

(2011) Thi A. Tran et al.   PLoS One

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

(2011) Blake Byers et al.   PLoS One

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson’s disease phenotype in the mouse

(2010) Naveen Kumar Singhal et al.   JOURNAL OF PINEAL RESEARCH

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease

(2010) Shin-ichi Muramatsu et al.   MOLECULAR THERAPY

Inflammation and Parkinson's disease pathogenesis

(2010) Serge Przedborski   MOVEMENT DISORDERS

A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease

(2010) Enza Lonardo et al.   STEM CELLS

Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson's disease

(2009) Yin Xia Chao et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease

(2008) Fiona E. O’Keeffe et al.   BRAIN

Therapeutic potentials of human embryonic stem cells in Parkinson’s disease

(2008) Mary B. Newman et al.   Neurotherapeutics

Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease

(2007) Allison D. Ebert et al.   EXPERIMENTAL NEUROLOGY