Unraveling the molecular mechanism of novel leukemia mutations on NTRK2 (A203T & R458G) and NTRK3 (E176D & L449F) genes using molecular dynamics simulations approach

The Structural Effect of FLT3 Mutations at 835th Position and Their Interaction with Acute Myeloid Leukemia Inhibitors: In Silico Approach

(2021) Abeer M. Al-Subaie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery and Characterization of Targetable NTRK Point Mutations in Hematologic Neoplasms

(2020) Sunil Kumar Joshi et al.   BLOOD

Effect of novel leukemia mutations (K75E & E222K) on interferon regulatory factor 1 and its interaction with DNA: insights from molecular dynamics simulations and docking studies

(2020) Balu Kamaraj et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Prioritization of SNPs in y+LAT-1 culpable of Lysinuric protein intolerance and their mutational impacts using protein-protein docking and molecular dynamics simulation studies

(2019) Chandrasekhar Gopalakrishnan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibiting TRK Proteins in Clinical Cancer Therapy

(2018) Allison Lange et al.   Cancers

Structural characterization of nonactive site, TrkA-selective kinase inhibitors

(2016) Hua-Poo Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study

(2015) Balu Kamaraj et al.   PLoS One

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

TRKing Down an Old Oncogene in a New Era of Targeted Therapy

(2014) Aria Vaishnavi et al.   Cancer Discovery

Computational Screening of Disease-Associated Mutations in OCA2 Gene

(2013) Balu Kamaraj et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Investigation of Binding Phenomenon of NSP3 and p130Cas Mutants and Their Effect on Cell Signalling

(2013) Balu K. et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

In SilicoScreening and Molecular Dynamics Simulation of Disease-Associated nsSNP in TYRP1 Gene and Its Structural Consequences in OCA3

(2013) Balu Kamaraj et al.   Biomed Research International

Structural and Biophysical Characterization of the Syk Activation Switch

(2012) Ulrich Grädler et al.   JOURNAL OF MOLECULAR BIOLOGY

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

(2008) M. H. Tomasson et al.   BLOOD

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS