The Structural Effect of FLT3 Mutations at 835th Position and Their Interaction with Acute Myeloid Leukemia Inhibitors: In Silico Approach

Effect of novel leukemia mutations (K75E & E222K) on interferon regulatory factor 1 and its interaction with DNA: insights from molecular dynamics simulations and docking studies

(2020) Balu Kamaraj et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Targeting FLT3 mutations in AML: review of current knowledge and evidence

(2019) Naval Daver et al.   LEUKEMIA

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

(2019) Peter van Galen et al.   CELL

The mutational spectrum of FLT3 gene in acute lymphoblastic leukemia is different from acute myeloid leukemia

(2019) Yu Zhang et al.   CANCER GENE THERAPY

Prioritization of SNPs in y+LAT-1 culpable of Lysinuric protein intolerance and their mutational impacts using protein-protein docking and molecular dynamics simulation studies

(2019) Chandrasekhar Gopalakrishnan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

FLT3 mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development

(2019) Hitoshi Kiyoi et al.   CANCER SCIENCE

Exploring the functional impact of mutational drift in LRRK2 gene and identification of specific inhibitors for the treatment of Parkinson disease

(2018) Nagasundaram Nagarajan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

The role of FLT3 inhibitors in the treatment of FLT3-mutated acute myeloid leukemia

(2017) Amir T. Fathi et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Genotype–phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants

(2017) Osama K. Zaki et al.   HUMAN MOLECULAR GENETICS

Molecular Dynamics Validation of Crizotinib Resistance to ALK Mutations (L1196M and G1269A) and Identification of Specific Inhibitors

(2017) Nagarajan Nagasundaram et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions

(2017) Maria Larrosa-Garcia et al.   MOLECULAR CANCER THERAPEUTICS

The Future of Targeting FLT3 Activation in AML

(2017) Mark B. Leick et al.   Current Hematologic Malignancy Reports

How I treat FLT3-mutated AML

(2016) Keith W. Pratz et al.   BLOOD

FLT3 Inhibitors for Treating Acute Myeloid Leukemia

(2016) Mona Hassanein et al.   Clinical Lymphoma Myeloma & Leukemia

Molecularly targeted therapy in acute myeloid leukemia

(2016) Harinder Gill et al.   Future Oncology

Mutational Analysis on Membrane Associated Transporter Protein (MATP) and Their Structural Consequences in Oculocutaeous Albinism Type 4 (OCA4)-A Molecular Dynamics Approach

(2016) Balu Kamaraj et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Two patients with Canavan disease and structural modeling of a novel mutation

(2016) Osama K Zaki et al.   METABOLIC BRAIN DISEASE

Secondary mutations as mediators of resistance to targeted therapy in leukemia

(2015) N. Daver et al.   BLOOD

FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors

(2015) C C Smith et al.   LEUKEMIA

PubChem Substance and Compound databases

(2015) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397

(2015) C. C. Smith et al.   Cancer Discovery

Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220)

(2015) Julie A. Zorn et al.   PLoS One

Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study

(2015) Balu Kamaraj et al.   PLoS One

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Contribution of hydrogen bonds to protein stability

(2014) C. Nick Pace et al.   PROTEIN SCIENCE

Computational Screening of Disease-Associated Mutations in OCA2 Gene

(2013) Balu Kamaraj et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Investigation of Binding Phenomenon of NSP3 and p130Cas Mutants and Their Effect on Cell Signalling

(2013) Balu K. et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance

(2013) Michael R. Grunwald et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

FLT3tyrosine kinase inhibitors in acute myeloid leukemia: clinical implications and limitations

(2013) Sabine Kayser et al.   LEUKEMIA & LYMPHOMA

In SilicoScreening and Molecular Dynamics Simulation of Disease-Associated nsSNP in TYRP1 Gene and Its Structural Consequences in OCA3

(2013) Balu Kamaraj et al.   Biomed Research International

Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation

(2012) C. H. Man et al.   BLOOD

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

(2012) Catherine C. Smith et al.   NATURE

Drug resistance in mutant FLT3-positive AML

(2010) E Weisberg et al.   ONCOGENE

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Radius of gyration as an indicator of protein structure compactness

(2008) M. Yu. Lobanov et al.   MOLECULAR BIOLOGY