Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies

Development of Biosimilars—Pharmacokinetic and Pharmacodynamic Considerations

(2010) Yow-Ming C. Wang et al.   Journal of Biopharmaceutical Statistics

European Medicines Agency workshop on biosimilar monoclonal antibodies

(2010) Janice M. Reichert et al.   mAbs

Human immunoglobulin allotypes

(2010) Roy Jefferis et al.   mAbs

An improved trypsin digestion method minimizes digestion-induced modifications on proteins

(2009) Da Ren et al.   ANALYTICAL BIOCHEMISTRY

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Characterization of Protein Impurities and Site-Specific Modifications Using Peptide Mapping with Liquid Chromatography and Data Independent Acquisition Mass Spectrometry

(2009) Hongwei Xie et al.   ANALYTICAL CHEMISTRY

Separation of 2-aminobenzamide labeled glycans using hydrophilic interaction chromatography columns packed with 1.7μm sorbent

(2009) Joomi Ahn et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab

(2009) Carola W. N. Damen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Gearing up for follow-on biologics

(2009) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab

(2009) Charlotte Magdelaine-Beuzelin et al.   Pharmacogenetics and Genomics

The effects of alpha-helix on the stability of Asn residues: Deamidation rates in peptides of varying helicity

(2009) Andrew A. Kosky et al.   PROTEIN SCIENCE

The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS/MS

(2009) Scott J. Geromanos et al.   PROTEOMICS

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

(2009) Royston Jefferis   TRENDS IN PHARMACOLOGICAL SCIENCES

Method to Differentiate Asn Deamidation That Occurred Prior to and during Sample Preparation of a Monoclonal Antibody

(2008) Georgeen Gaza-Bulseco et al.   ANALYTICAL CHEMISTRY

Editorial [Hot Topic: Therapeutic Antibodies and Derivatives: From the Bench to the Clinic(Guest Editor: Alain Beck)]

(2008) A. Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Monoclonal Antibodies as Innovative Therapeutics

(2008) Janice Reichert   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

(2008) Alain Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Comparison of LC and LC/MS methods for quantifying N-glycosylation in recombinant IgGs

(2008) Sandipan Sinha et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Western biotechs ponder follow-on possibilities

(2008) Emily Waltz   NATURE BIOTECHNOLOGY

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

(2008) Christine H. Chung et al.   NEW ENGLAND JOURNAL OF MEDICINE