RAS and PP2A activities converge on epigenetic gene regulation

Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061

(2022) Gianmatteo Vit et al.   EMBO JOURNAL

ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II

(2022) Seina Ohe et al.   Nature Communications

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

(2021) Stephin J. Vervoort et al.   CELL

Druggable cancer phosphatases

(2021) Julia P. Vainonen et al.   Science Translational Medicine

JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer

(2021) E. Josue Ruiz et al.   JCI Insight

Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It

(2021) Jiayu Zou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

(2020) Kari J. Kurppa et al.   CANCER CELL

Phosphoproteome and drug response effects mediated by the three Protein Phosphatase 2A inhibitor proteins CIP2A, SET and PME-1

(2020) Otto Kauko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Frequency of Ras Mutations in Cancer

(2020) Ian A. Prior et al.   CANCER RESEARCH

Good Guy in Bad Company: How STRNs Convert PP2A into an Oncoprotein

(2020) Kari J. Kurppa et al.   CANCER CELL

Regulation of histone deacetylase activities and functions by phosphorylation and its physiological relevance

(2020) Sonali Bahl et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer

(2020) Anthony Quagliano et al.   Frontiers in Oncology

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

(2020) Kai-Lieh Huang et al.   MOLECULAR CELL

PPP2R2D suppresses IL-2 production and Treg function

(2020) Wenliang Pan et al.   JCI Insight

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

(2020) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The Open Chromatin Landscape of Non-small Cell Lung Carcinoma

(2019) Zhoufeng Wang et al.   CANCER RESEARCH

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Protein phosphatases in chromatin structure and function

(2018) Raquel Sales Gil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Scaling read aligners to hundreds of threads on general-purpose processors

(2018) Ben Langmead et al.   BIOINFORMATICS

Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer

(2018) Otto Kauko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evolution of telomere maintenance and tumour suppressor mechanisms across mammals

(2018) Xiao Tian et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

(2018) Otto Kauko et al.   Science Translational Medicine

PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis

(2016) Xiaorong Zhou et al.   CANCER RESEARCH

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   NATURE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Determinants of Cancer

(2016) Stephen B. Baylin et al.   Cold Spring Harbor Perspectives in Biology

Association of chromosome 19 to lung cancer genotypes and phenotypes

(2015) Xiangdong Wang et al.   CANCER AND METASTASIS REVIEWS

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites

(2015) Seung-Tae Lee et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of epigenetic “readers, writers and erasers”: Implications for developmental reprogramming and the epigenetic basis for health and disease

(2015) Lindsey S. Treviño et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer

(2015) Hao Liu et al.   Oncotarget

CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations

(2015) Anchit Khanna et al.   Oncotarget

Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling

(2015) Otto Kauko et al.   Scientific Reports

A Recombinant Reporter System for Monitoring Reactivation of an Endogenously DNA Hypermethylated Gene

(2014) Y. Cui et al.   CANCER RESEARCH

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

(2014) Anne Laugesen et al.   Cell Stem Cell

Human Lung Epithelial Cells Progressed to Malignancy through Specific Oncogenic Manipulations

(2013) Mitsuo Sato et al.   MOLECULAR CANCER RESEARCH

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

(2013) M. Bohgaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling

(2012) Patrick Boyle et al.   GENOME BIOLOGY

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

(2012) Altuna Akalin et al.   GENOME BIOLOGY

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

Identification of PP2A Complexes and Pathways Involved in Cell Transformation

(2010) A. A. Sablina et al.   CANCER RESEARCH

Solving the RIDDLE of 53BP1 recruitment to sites of damage

(2010) Grant S. Stewart   CELL CYCLE

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY