ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II

Structure and mechanism of the RNA polymerase II transcription machinery

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Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression

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ERK signalling: a master regulator of cell behaviour, life and fate

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Causes and consequences of RNA polymerase II stalling during transcript elongation

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Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer

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Born to run: control of transcription elongation by RNA polymerase II

(2018) Fei Xavier Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

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Targeting PP2A in cancer: Combination therapies

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Structure of paused transcription complex Pol II–DSIF–NELF

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Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

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An immediate–late gene expression module decodes ERK signal duration

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Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II

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MCRIP1, an ERK Substrate, Mediates ERK-Induced Gene Silencing during Epithelial-Mesenchymal Transition by Regulating the Co-Repressor CtBP

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Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways

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Enhancer RNA Facilitates NELF Release from Immediate Early Genes

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Protein phosphatase 2A: a target for anticancer therapy

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Immediate early response genes and cell transformation

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Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

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Sanguinarine as a Potent and Specific Inhibitor of Protein Phosphatase 2Cin Vitroand Induces ApoptosisviaPhosphorylation of p38 in HL60 Cells

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CDK8 is a positive regulator of transcriptional elongation within the serum response network

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Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis

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Negative elongation factor NELF controls transcription of immediate early genes in a stimulus-specific manner

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